Biographical Memoirs Volume 69 (1996) / Chapter Skim
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SUSUMU HAGIWARA
SUSUMU HAGIWARA
Pages 58-85
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From page 59... ...
corresponclingly on cloucly clays. His thesis topic, the fluctuation of intervals in rhythmic excitation in frog stretch receptors, with comparisons to the intervals in human motor units cluring voluntary movement, foretoIc!
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From page 60... ...
in one camp or the other. One of the fascinations of this man's career is that a true hero of general physiology owes the essence of his fame to comparative studies, not in the usual sense that he spent his life on an unconventional favorable species but in sampling many species, far apart phylogenetically, upward of sixty different preparations in about as many species, from plants to humans, from clonal pituitary cells to leech neurons, from cicadas to barnacles, giant squid to bats, chirping bircis to clam larvae, soft corals to mouse hybricloma cells, invertebrate eggs to cats.
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From page 61... ...
later the simple photoreceptors in barnacles. Fincling himself on the Great Barrier Reef or the Amazon River, Hagi couIc!
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in experience en c! papers on the physiology of taste in cats, cardiac ganglion pattern generators in lobsters, giant synapses in squid, stretch receptors in crayfish, en c!
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One notable trip was in March 1964 to the U.S.-lapan Joint Cooperative Program Symposium on Neurophysiology, for which the Japanese clelegation, lee! by Yasuji Katsuki, incluclec!
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From page 64... ...
to the then-clirector of the UCLA Brain Research Institute, John D French, who had persuaded the Scripps faculty to cosponsor with the institute a unique, and for many years jointly operated, marine neurobiology facility on the third floor of Scholander's new Physiological Research Laboratory.
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From page 65... ...
several papers in French with Thomas Szabo. With a group of postdoctoral associates, Hagiwara initiated the Marine Neurobiology Facility of Scripps and the Brain Research Institute.
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From page 66... ...
an icleal preparation in the muscle fibers of Chilean giant barnacles. Two years later he was off to New Guinea on an Alpha Helix expedition lee!
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From page 67... ...
These questions led him to study preparations such as muscle fibers in barnacles, mussels, and amphioxus, eggs of starfish, annelicis, en c! Drosophila, mucipuppy hair cells, crustacean photoreceptors, chromaffin cells in rats, lymphocytes and tumor cells in mice, seminiferous tubule cells, pituitary cells, left-handed snail cells, and human T cells.
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From page 68... ...
with calcium channels in cell membranes. Whereas the action potential hac!
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From page 69... ...
Hagi's cliscovery that intracellular calcium blocks calcium channels was the first clear demonstration of an important mechanism of calcium channel inactivation. Hagiwara's analysis of calcium permeation in terms of bincling affinities, dissociation constants, en c!
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en c! pioneered its application to the stucly of small mammalian cells whose membrane properties were previously almost completely unknown, such as pituitary cell lines en c!
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In the early 1960s the Brain Research Institute at UCLA was planning an outpost, the Marine Neurobiology Facility at the Scripps Institution of Oceanography of UCSD in La Jolla, which he was later recruitec! to heacI, as we recountec!
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From page 72... ...
In addition, another factor can be inadequately termed ingenuity. This was nicely shown in his sandwich preparation of the barnacle muscle fiber membrane from an opened fiber laid flat between holders that present the inside of the membrane to one chamber and the outside to another.
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He was the first to make a barnacle muscle membrane spike, although this type of cell has probably not given a spike for huncirecis of millions of years. He starter!
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Ion Channels in Cell Membranes: Phylogenetic and Developmental Approaches (1983~. In 1983 a symposium volume was publishec!
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Watanabe. Action potentials recorded from inside a Mauthner cell of the cat-fish.
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Capacity of muscle fiber membrane.
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Naka. The initiation of spike potential in barnacle muscle fibers under low intracellular Ca++.
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Chichibu. Relation between membrane potential changes and tension in barnacle muscle fibers.
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lunge. Excitation-contraction coupling in a barnacle muscle fiber as examined with voltage clamp technique.
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Hayashi. Mechanisms of anion and cation permeations in the resting membrane of a barnacle muscle fiber.
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Sand. Voltage clamp analysis of two inward current mechanisms in the egg cell membrane of a starfish.
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Electrical properties of egg cell membranes. Annul Rev.
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Studies of calcium channels in the rat clonal pituitary cells with patch electrode voltage clamp.
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Studies of single calcium channel currents in rat clonal pituitary cells.
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Neuronal modulation of calcium channel activity in cultured rat astrocytes.
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