Biographical Memoirs Volume 70 (1996) / Chapter Skim
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Leon Orris Jacobson
Leon Orris Jacobson
Pages 190-203
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on all who knew him. Leon Orris Jacobson was born on December 16, 1911, in Sims, North Dakota, a town that exists tociay only in memories because the Northern Pacific railroac!
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a B.A. from North Dakota State University in 1935.
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the hospital with members of the various departments in the Division of the Biological Sciences and included investigators in fielcis ranging from protein chemistry, steroic! biochemistry, en c!
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to direct, for a short time, the Franklin McLean Institute, which was the Argonne Cancer Research Hospital uncler a new name. He became professor emeritus in 1976 but continues!
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In collaboration with Clarence Lushbaugh he stucliec! close effects of these toxic compounds in causing severe decrease in white cell number of experimental animals.
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therapy of a devastating disease: It may be difficult for many to understand the deep concern one has when one is giving an extremely toxic but potentially therapeutically effective chemical to a patient for the first time. True, one has the advantage, in a deliberately planned human experiment such as this, that the dose is controlled or calculated from experience with animals and from knowledge of all the specific organ and systemic effects of a wide variety of dose schedules.
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In an attempt to determine the relative importance of spleen versus bone marrow in overall hemopoiesis he subjectec! mice to an otherwise lethal close of X rays to destroy the bone marrow while the spleen was exteriorized en c!
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His intuition, guidance, and unstinting support led to major advances in the study of erythropoietin including the finclings that it was macle in the kiciney en c! that its production was regulated by the need for oxygen relative to the availability of hemoglobin.
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with him or who hac! the great good fortune to be part of his staff in the Argonne Cancer Research Hospital.
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Comparative therapeutic effects of radioactive and chemical agents in neoplastic diseases of the hemopoietic system.
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Block. A clinical study of the use of nitrogen mustard therapy in polycythemia Vera.
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XI. Reticulocyte response of transfusion-induced polycythemic mice to anemic plasma from nephrectomized mice and to plasma from nephrectomized rats exposed to low oxygen.
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