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Adequacy of the Comprehensive Clinical Evaluation Program Nerve Agents (1997) / Chapter Skim
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TESTING FOR AND IDENTIFYING HEALTH EFFECTS OF EXPOSURE TO NERVE AGENTS
Pages 11-14

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From page 11...
... Experimental studies on the long-term effects of satin on animals and humans have produced inconclusive results. In 1982, the National Research Council conducted a study examining long-term or delayed adverse health effects of 15 anticholinesterases tested on about 1,400 military volunteers during the 1960s and 1970s.
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From page 12...
... Research on exposure to organophosphate pesticides, some of the most acutely toxic and potentially lethal pesticides in use today, may provide information useful to those studying the effects of sarin and cyclosarin because these types of pesticides and nerve agents both inhibit cholinesterase. Acute symptoms of poisoning from these OP pesticides can be as severe as those found with any nerve agent, but the long-term neurobehavioral health effects in the absence of acute clinical effects at the time of exposure are still debated A study of individuals occupationally exposed to organophosphate pesticides examined workers without acute, clinical symptoms, but with blood measurements that showed depressed cholinesterase levels.
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From page 13...
... An accurate, etiologic diagnosis of a neuropathy cannot be based on symptoms alone. A simple, reliable neuropathy diagnosis requires a neurologist, a set of noninvasive diagnostic instruments including a thorough patient history questionnaire; clinical examination questions about sensory, motor, and autonomical functions; and simple nerve conduction and quantitative sensory tests.
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From page 14...
... It is important to explicitly rule out other potential causes of impairment such as age, education, smoking, alcohol use, developmental disorders, psychiatric disorders, neurological disorders, and motivational states in which persons consciously or unconsciously sabotage their own test performance. A recent study of Oregon veterans investigated psychosocial, neuropsychological, and neurobehavioral elements to determine objective memory and attention impairment.
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Key Terms

  • quantitative sensory
  • neuropathy diagnosis
  • organophosphate pesticides
  • sensory testing
  • nerve agent

  • neurotoxicant exposure
  • peripheral neuropathies
  • patient history
  • junctional myopathies
  • neurobehavioral tests

  • persian gulf
  • nerve conduction
  • pesticides examined
  • completely detoxified
  • determine objective

  • muscle damage
  • acute anticholinesterase
  • depressed cholinesterase
  • acutely toxic
  • surveyed carries

  • decreased ankle
  • adverse human
  • concentration exposure
  • motivational states
  • psychiatric disorders

  • occupationally exposed
  • bind temporarily
  • examination questions
  • include mild
  • oregon veterans


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