Biographical Memoirs Volume 72 (1997) / Chapter Skim
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EMIL THOMAS KAISER
EMIL THOMAS KAISER
Pages 218-233
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From page 219... ...
'Tis the courage you bring to it." That may be true for most people, but it certainly isn't true for the tiny fraction of humanity who are highly creative, their lives matter even more than their courage because they change the work!
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He and Professor Corey created a remarkable piece of physical-organic chemistry that demonstrated that sulfone anions can retain their chirality, at least briefly, he and Professor Bender investigated the cinnamoyl intermediates3 formed in the hydrolysis of cinnamoyl esters by trypsin and chymotrypsin. He was now well launched on his career in bioorganic chemistry, with experience in both physical-organic chemistry and enzymology.
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From page 221... ...
SEMISYNTHETIC ENZYMES4 5 Enzyme kineticists separate binding en c! catalysis.
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From page 222... ...
The resulting semisynthetic enzyme attacks NADH rapidly, a similar semisynthetic enzyme can be macle from hemoglobin. SYNTHESIS OF PEPTIDES AND PROTEINS Another powerful iclea with semisynthetic enzymes concerns a highly original way of utilizing thiosubtilisin.
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From page 223... ...
transfers the peptide residue to another peptide, completing the ligation reaction, but, since it is a poor pepticiase, it cloes not attack the resulting product at all rapidity. Because of this work chemical synthesis can now complement the methods of molecular biology in forming proteins.
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From page 224... ...
Although the scientific community has some understanding of the way in which proteins work, both with respect to binding and catalysis, we are just beginning to understand the reasons for their secondary and tertiary structures. Kaiser's work showed the importance of secondary structure and in particular the reasons why amphiphilic helices are essential to biological activity.
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From page 225... ...
It was clesignec! with 12 leucine residues and ~ tryptophane, properly spaced to mimic the hydrophobic portion of the amphiphilic helix, en c!
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From page 226... ...
Here in Kaiser's work is part of the experimental demonstration that this is so. SITE-DIRECTED MUTAGENESIS Although semisynthetic enzymes and amphiphilic helices constitute the principal contributions from Kaiser's laboratory, at least one other aspect of his work (i.e., site-clirectec!
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From page 227... ...
If enzymes most enzymes, at any rate and receptors are proteins, we should then understand the way proteins interact with their receptors and membranes, we should at least understand the importance of secondary structures. COURAGE We have described the remarkable science Kaiser achieved and outlined the impact of his work on the future of chemistry, but we have told only half the story.
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From page 228... ...
not allow anything certainly not personal discomfort or risk to interfere with his contributions to science. Tom Kaiser macle these matter-of-fact comments concerning clialysis en c!
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We know that we have lost a friend, that the scientific community has lost a great scientist, en c! we have all lost a role moclel for facing Diversity with courage.
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Biological and physical properties of a beta endorphin analog containing only D-amino acids in the amphiphilic helix segment.
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From page 232... ...
Patthi. Design and biological activity of analogs of growth hormone releasing factor with potential amphiphilic helical carboxyl termini.
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