Biographical Memoirs Volume 72 (1997) / Chapter Skim
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ALBERT DORFMAN
ALBERT DORFMAN
Pages 70-87
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From page 71... ...
the basis for many meclical advances in human biochemical genetics, as well as in prenatal diagnosis of genetic diseases that cause mental retardation. One of his many scientific accomplishments was discovering the cause of Hurier's syndrome, a genetic disease that affects the bones en c!
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From page 72... ...
biochemistry so interesting that he began graduate work in this discipline and dropped out of medical school after two years. Early in his graduate work he came in contact with Felix Saunders, who was then interested in bacterial metabolism, a field yet in its infancy.
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with the identification of nicotinamicle as a growth requirement for Shigella dysenter~ae en c! the synthesis of various nicotinic acid derivatives to correlate structure with biological activity ~939)
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Because of a publication at this time by Guerra claiming that aspirin exerted its antirheumatic effect by inhibition of hyaluronidase, he initiated studies on connective tissue polysaccharides, an area of research which he pursued for the next thirty years. In particular, his earlier experiences in bacterial metabolism and carbohydrate chemistry served as an excellent background to pursue the biosynthesis of hyaluronic acid in Group A streptococci.
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Neither glucuronic acid nor glucuronolactone was fount! to be direct precursors of the glucuronic acid residues in hyaluronic acid ~ ~ 953, ~ 954, ~ 955)
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significantly to the unclerstancIing of the biosynthesis of other glycosaminoglycans. The biosynthesis of sulfated glycosaminoglycans by eucaryotic cells required the study of additional reactions not necessary for hyaluronic acid formation because of the sulfate content en c!
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more conclusive evidence concerning the mechanism by which genetic information is translates! to a specific monosaccharide sequence in carbohycirate-containing macromolecules.
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Mathews on cartilage proteoglycansthe native form of the chonciroitin sulfates in the tissueswith Dorfman's research on metabolism, resulting in early studies of the turnover of the protein en c! carbohydrate moieties of these complex carbohydrates.
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heparan sulfate were consiclerec! to be distinct entities without any common structural features.
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the existence of a oc-L-icluroniciase by demonstrating release of iduronic acid from desulfated dermatan sulfate upon incubation with an extract of normal fibroblasts, en c! preliminary experiments also shower!
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clegraciation of matrix components lee! naturally to an inquiry into more biological aspects of complex carbohydrates.
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succeeclec! in cleveloping a cell-free system for synthesis of proteoglycan core protein and type II collagen, and, finally, using recombinant DNA technology to isolate cDNA clones for type I and II collagen with William UphoTt (1979~.
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as president of the Pediatric Society in 1979 container! pleas concerning the clemise of basic research en c!
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Ludowieg. The biosynthesis of hyaluronic acid by group A streptococcus.
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Synthesis of capsular polysaccharide (hyaluronic acid) by protoplast membrane.
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Stimulation of chondroitin sulfate proteoglycan production by chondrocytes in monolayer. Connect.
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Simultaneous localization of type II collagen and core protein of chondroitin sulfate proteoglycan in individual chondrocytes.
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