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Biomedical Models and Resources Current Needs and Future Opportunities (1998) / Chapter Skim
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4. Overriding Issues
Pages 19-23

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From page 19...
... Some support can come from user fees but frequently total recovery of costs of animal colony maintenance results in user fees that are prohibitively high for investigators' research grants. The P40 mechanism has been successfully used by NCRR to help support model organism colonies and should be continued and expanded.
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From page 20...
... Major forces causing the depletion are the explosion in the number of genetically altered mice; the increasing animal care regulations; the increased demand for space to respond to them; the increased technology, such as barrier caging, required for housing laboratory animals; and the decrease in funding available from NCRR for construction and renovation of animal care facilities. AVAILABILITY OF EXPERTISE AND TRAINING Biomedical science is moving into the next phase of understanding the function at the whole-organism level of genes identified at the molecular level.
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From page 21...
... program supported by NCRR, the added cost to individual investigators due to the Circular A-21 requirements, the widespread use and transfer from institution to institutio of transgenic and gene "knockout" mouse models, and emerging adventitious infectious agents not previously recognized. In addition to the obvious risk of losing irreplaceable colonies to infectious disease, this is a very important issue because of the confounding effects, including known mistakes of interpreting results from animal studies due to previously unknown underlying infections; these pathogens are undetected because in many institutions systems to monitor and eliminate them are poorly supported.
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From page 22...
... CIRCULAR A-21 Many survey respondents and workshop participants considered the designation of animal care facilities as a specialized service facility under OMB Circular A-21 (Federal Register 1997) to be an impediment to biomedical research.
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From page 23...
... This problem is exacerbated by the increasing capability of data-analysis methods to extract individual and confidential information from extensive collections of ostensibly innocuous research data. This issue is beyond the scope of this study on biomedical models, but it is mentioned because failure to resolve it is a potential impediment to future sharing of data related to comparison of biomedical models and human conditions.
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Key Terms

  • genetically altered
  • altered mice
  • care facilities
  • animal models
  • infectious diseases

  • biomedical models
  • cost allocation
  • animal research
  • infectious agents
  • murine pathogens

  • diem charges
  • investigators due
  • animal facilities
  • user fees
  • cost centers

  • health surveillance
  • omb circular
  • direct cost
  • laboratory animals
  • adventitious infectious

  • individual investigators
  • considerable detail
  • diagnostic laboratories
  • contain data
  • integrative expertise

  • decreasing animal
  • difficulty diagnosing
  • research access
  • highly mobile
  • initial development


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