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Dietary Reference Intakes Proposed Definition and Plan for Review of Dietary Antioxidants and Related Compounds (1998) / Chapter Skim
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Proposed Definition
Pages 3-5

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From page 3...
... in humans, the substance decreases the adverse effects of reactive oxygen and nitrogen species in vivo. Thus, the panel developed the following proposed definition of a dietary antioxidant: A dietary antioxidant is a substance in foods that significantly decreases the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiologicalfunction in humans.
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From page 4...
... It is recognized that limitations exist in the use of food composition databases to accurately estimate intakes. Decreased Adverse Effects of Some ROS and RNS In order to meet the definition of a dietary antioxidant proposed here, the nutrient or food component must decrease the adverse effects of some ROS and RNS (see Table 1 for examples of ROS and RNS)
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From page 5...
... A considerable body of biological evidence shows that ROS and RNS can damage cells and other body components and could in theory contribute to dysfunction and disease states. It has been postulated that oxidative damage caused by increased levels of production of ROS or RNS may contribute to the development of many chronic diseases, including age-related eye disease, atherosclerosis, cancer, coronary heart disease, diabetes, inflammatory bowel disease, neurodegenerative diseases, respiratory disease, and rheumatoid arthritis.
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Key Terms

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  • human body
  • free radicals
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  • human diets

  • body components
  • panel developed
  • oxygen species
  • limitations exist
  • lipid peroxidation

  • respiratory disease
  • food components
  • repairing oxidative
  • reactive nitrogen
  • available national

  • bowel disease
  • physiological mechanisms
  • normal physiological
  • reacting directly
  • decreased adverse


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