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Vaccines Against Malaria (1996) / Chapter Skim
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4 Current Obstacles to Development
Pages 15-16

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From page 15...
... Selecting the optimal antigens from among the stages in the parasite's life cycle and devising optimal formulations and delivery systems to elicit the desired immunologic response is a complex and difficult task one that must be based on scientific knowledge, but will also require empirical testing of multiple potential vaccine products. Current knowledge of protective immunity to malaria has been derived, in part, from studies of malaria in animals and from human trials of experimental vaccines.
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From page 16...
... . As a result, gove~nment-funded vaccine development remains disarticulated, with no overall strategy in place, and there is inadequate communication and coordination among malaria vaccine researchers and developers in government, academia, and industry.
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Key Terms

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  • vaccine entities
  • producing antigens
  • nor obtained

  • predicting human
  • development reflects
  • workshop complained
  • limited success
  • empirical testing

  • sought nor
  • activities directed
  • cell response
  • substantial progress
  • facing malaria

  • distinct developmental
  • federal strategy
  • scientific hurdles
  • avoidance strategies
  • remains disarticulated

  • approaches tested
  • immune response
  • vaccine coordinating
  • limited value
  • greatly advanced

  • accelerating malaria
  • vaccine products
  • critical importance
  • difficult task
  • hurdles facing


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