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Permissible Exposure Levels for Selected Military Fuel Vapors (1996) / Chapter Skim
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11 Genotoxic Effects of Military Fuel Vapors
Pages 101-103

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From page 101...
... In the tests on JP-S, in vitro assays used microbial and mammalian cells in culture, and in viva assays measured potential germ-cell effects in mice and rats. JP-8 fuel did not induce mutagenicity in Salmonella typhimurium in the Ames assay; however, it did have toxic effects in most of the bac
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From page 102...
... Although JP-4 was found to alter DNA and form repairable DNA lesions, these lesions are not necessarily mutagenic. In the dominant lethal assay, JP-4 was tested at concentrations of 0.01, 0.03, or 0.09 ml=/lcg in mice and at concentrations of
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From page 103...
... Tests on JP-5 also did not result in evidence of mutagenicity. JP-S was tested in the Ames assay with Salmonella typhimurium TA~ 535, TA- ~ 537, TA-97, TA-9S, ant!
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Key Terms

  • lymphoma cells
  • dna synthesis
  • mammalian cells
  • unscheduled dna
  • toxic effects

  • salmonella typhimurium
  • ames assay
  • measured potential
  • necessarily mutagenic
  • dna lesions

  • repairable dna
  • vitro assays
  • assays measured
  • induce unscheduled
  • alter dna

  • induce mutagenicity
  • fuel produces
  • dominant lethal
  • form repairable
  • metabolic activation

  • lethal assays
  • hamster liver
  • lethal assay
  • induced significant
  • significant genetic

  • significant increases
  • producing nonspecific
  • assay testing
  • nonspecific lesions
  • genetic risk


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