Permissible Exposure Levels for Selected Military Fuel Vapors (1996) / Chapter Skim
Currently Skimming:
8 Effects of Military Fuel Vapors on the Liver
8 Effects of Military Fuel Vapors on the Liver
Pages 69-81
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 69... ...
HEPATIC EFFECTS OF JP-5 FUEL VAPORS In an acute-exposure study involving male Sprague-Dawley rats, petroleum-derived and three samples of shale-derived JP-5 fuel were administered in single oral doses of 60, 4S, 38, 30, or 24 mL/Icg of body weight (assuming an average density of ~ ~ 6 Icg/m3; 49, 39, 3l, 24, or 20 king, respectively) Parker et al., 1981~.
|
From page 70... ...
The animals that died during the 14-day observation had swollen and mottled livers with accentuated lobular patterns. Histopathological investigation of survivors showed hepatic periportal fatty changes.
|
From page 71... ...
In rats exposed for 90 days to petroleum JP-5 vapor at 150 or 750 mg/m3, there were no liver histopathological changes or serum enzyme changes immediately after the exposure. Mild hepatic hyperplasia was observed at both concentrations in animals that died after the 90-day exposure or were held ~ 9 or 2 ~ months after exposure.
|
From page 72... ...
m3 for 6 hr per day, 5 days per weelc for 6 weeks did not result in any adverse effects in the liver, and there was no change in serum enzyme levels. HEPATIC EFFECTS OF JP-8 FUEL VAPORS In subchronic inhalation studies, male ant!
|
From page 73... ...
HEPATIC EFFECTS OF DFM FUEL VAPORS In subchronic inhalation studies (MacEwen and Vernot, ~ 97S, ~ 980, ~ 982, ~ 983, ~ 985) , male and female beagles (three of each)
|
From page 74... ...
For mice exposed to petroleum DFM vapor at 300 mgim3, an ncreased number of inflammatory cells were observed in the liver at the time that exposure ceased. Nineteen to 21 months after i exposure, there were no important liver changes or increased tumor incidence.
|
From page 75... ...
No differences were found in serum aspartate aminotransferase and alkaline phosphatase levels in the two groups (Dossing et al., ~ 985~. In subchronic inhalation studies (MacEwen and Vernot, 1984, 1985)
|
From page 76... ...
Male rats also displayed decreased SGPT levels at the high concentration 5,000 mg~m3. Immediately after exposure, female rats had decreased SGPT levels at both concentrations anti, after ~ year, had liver noclular hyperplasia at 5,000 mgim3 but no primary liver neoplasms.
|
From page 77... ...
Table 8-l summarizes the liver toxicity of these military fuels. CONCLUSIONS The liver was found to be a target organ of orally administered jet fuels (total fuel)
|
From page 78... ...
78 au Cat C\: ._ . .= =~ offs-; a; oo ,% o ~ be oo o Cot _ Cut an Cat o · C~ ~ o ~ _ Cat ~ ·o · - ~ For ~ ~ _ Cut _ cry oo oo _ _ o o ~ of oo _ _ · ~ _ ~ ~ _ ~ oo ~ ~ - ~ ~ - ~ ~ ~ ~ ~ ~ ~ x x t ~ > - ~ > - .
|
From page 79... ...
79 ° Cat _ X _ ~ ~ _ ~ ~ ~ ~ _ .
|
From page 80... ...
MacNaughton and Uddin (1984) reported that dogs, rats, mice, and monkeys exposed to JP-4 at 2,500 or 5,000 mg/m3 for 6 hr per day, 5 days per week for g months exhibited no exposurerelated effects other than a slight increase in liver weights in female rats.
|
From page 81... ...
EFFECTS OF FUEL VAPORS ON THE LIVER 81 The subcommittee recommends that further research be conductect to evaluate the effect of military fuel vapors on hepatotoxicity in experimental animals; this research would help to identify the NOVEL with greater confidence.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.