Review of the U.S. Naval Medical Research Institute's Toxicology Program (1994) / Chapter Skim
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5 EVALUATION OF OTHER ISSUES RELATED TO IMPROVEMENT OF THE TOXICOLOGY PROGRAM
5 EVALUATION OF OTHER ISSUES RELATED TO IMPROVEMENT OF THE TOXICOLOGY PROGRAM
Pages 37-48
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From page 37... ...
Air Force toxicology laboratory result in significant scientific benefit? How should coordination be improved?
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From page 38... ...
Thus, regardless of whether the data are generated internally or externally, the hazard identification and doseresponse evaluations would require highly competent and well-trained individuals at the doctoral level in such disciplines as neurotoxicology, immunotoxicology, reproductive and developmental toxicology, pathology, carcinogenicity, inhalation toxicology, general toxicology, and biochemical toxicology. To generate data internally, a team of scientists should be assembled with the ability to organize and conduct research programs.
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From page 39... ...
determine acute, subacute, and chronic toxicity in animals for selected chemicals either through a literature search or by conducting animal studies when pertinent information is missing; (4) identify chemicals with potential for exposure, determine toxicity, and identify sensitive biological end points and biomarkers of exposure; (5)
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From page 40... ...
The subcommittee strongly supports the formation of a triservices toxicology program with civilians as key scientists who would provide the continuity necessary for high-quality science and training of junior scientists. Those key scientists would stay abreast of the advances in toxicology and their applicability to the armed services' needs.
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From page 41... ...
Synergy undoubtedly exists between the Navy and the Air Force toxicology units because of collocation at WPAFB and a willingness to cooperate. This relationship is enhanced by collocation with the contractoroperatect Toxic Hazards Research Unit (THRU)
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From page 42... ...
Duplication of resources could be avoided and a stronger cooperative effort could result from a joint agreement similar to the one just described to share resources and facilities. Major equipment purchases could be coordinated with the Air Force and Army to share the costs and, more Important, the benefits of the equipment.
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From page 43... ...
Relationships with Other DOD Sources of Expertise There is opportunity to combine NMRITD with its counterpart organizations from the Army and Air Force to form a triservice unit. The Armed Forces Institute of Pathology and the triservice combustion toxicology research program provide excellent examples of cooperation among the three services to strengthen scientific capabilities.
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From page 44... ...
Such BLAs should be encouraged, not only with foreign governments but also with various foreign organizations such as the United Nations Environmental Program, the World Health Organization, the International Labor Organization, and the International Program on Chemical Safety. The MOU and BLA are tools that could be used more effectively to leverage the Navy's research capabilities.
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From page 45... ...
However, certain very specialized techniques of toxicological investigation might not be immediately available there. Also, many highly specialized techniques require the commitment of considerable manpower or highly sophisticated and expensive technical equipment before they become fully functional and operable.
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From page 46... ...
In other words, the review process should be organized by an external group, preferably an academic institution or an arm of the National Research Council, such as the Committee on Toxicology. RECOMMENDATIONS ON RELATED ISSUES The subcommittee made the following recommendations on issues related to Improving NMRITD's toxicology program: · Highly competent individuals with expertise in various subspecialty fields of toxicology are essential to conducting health-risk assessments.
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From page 47... ...
· NMRTTD should continue to expand its relationships with other sources of scientific knowledge, such as other DOD organizations (e.g., the Armed Forces Institute of Pathology, the Armed Forces Epidemiology Board, the Army Corps of Engineers) , federal agencies (e.g., the Environmental Protection Agency, the National Institutes of Health, and the Occupational Safety and Health Administration)
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From page 48... ...
External contracts could ensure that work products from NMRITD represent state-of-the-art scientific toxicological information. Contracts should also be funded to support external scientific review processes.
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