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Microbial and Phenotypic Definition of Rats and Mice Proceedings of the 1998 US/Japan Conference (1999) / Chapter Skim
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Pages 61-68

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From page 61...
... PHILIP A WOOD 61 ment paradigms, but also specialized physiologic assessment with location specific brain implants and BEG type measures.
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From page 62...
... Considering the problem of trying to evaluate the myriad of effects resulting from a single genetic change is a daunting task. The goal of this presentation is to provide a framework to consider this important problem.
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From page 63...
... This presentation discusses key elements in the use of genetically defined mice: genetic standardization, standard genetic nomenclature, genetic definitions of different types of strains, and the value and uses of different types of genetically defined strains. The focus of this presentation is the laboratory mouse, Mus.
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From page 64...
... Inbred laboratory mice provide the possibility to do this. Individual mice within an inbred mutant strain are essentially genetically identical to each other except for the mutant gene being studied.
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From page 65...
... Inbred strains that differ in such traits can be crossed together to define the genetic basis of the differences and to determine the number and chromosomal location of genes involved. They also are used when multiple genetically identical animals are needed to test the effects of a treatment.
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From page 66...
... male; a D2B6 F1 is created by mating a DBA/2J female to a C57BL/6J male. Inbred mutant strains are inbred strains that carry one or more spontaneous or induced single gene mutations.
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From page 67...
... Because these sets are typically constructed after two backcrosses, each recombinant congenic strain usually contains approximately 87.5 % of its genes from the background strain and approximately 12.5% of its genes from the donor strain (Moon and others 1991; Stassen and others 1996~. As with recombinant inbred strains, a detailed characterization of SDPs of genes within a strain set may be used to determine linkage relationships between loci and chromosomal segments associated with a trait such as tumor susceptibility.
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From page 68...
... GENETIC DATABASES Several databases are available that have information on genetically standardized mice. The Mouse Genome Database mentioned above has a list of inbred strains of laboratory mice, as well as information on mouse genomics and gene expression.
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Key Terms

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  • jackson laboratory
  • genetic contamination
  • targeted mutation
  • inbred mutant
  • mutant strain

  • mutated gene
  • background strain
  • genetic background
  • mouse genome
  • defined mice

  • inbred strain
  • recombinant inbred
  • mutation strains
  • congenic strain
  • crossing mice

  • mutant mice
  • background monitoring
  • standardized jax
  • mutant gene
  • genetically standardized


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