Microbial and Phenotypic Definition of Rats and Mice Proceedings of the 1998 US/Japan Conference (1999) / Chapter Skim
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Pages 81-87
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From page 81... ...
. My friends at The Jackson Laboratory have educated me well regarding how the economics of preservation may favor increased cryopreservation.
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From page 82... ...
82 MICROBIAL AND PHENOTYPIC DEFINITION OF RATS AND MICE REFERENCE Dove, W., and D Cox (Summarizers)
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NEED FOR GENETICALLY DEFINED ANIMALS Of the needs I have heard expressed at this meeting, I have noted the important need for genetically defined animals. The problem involved in fulfilling this need is not just with the generation of the animals but also with defining the animals.
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From page 84... ...
the expression of a major gene modified by several modifier genes, rather than one gene simply not showing up in one setting quite as strongly as it does in other settings. This expression is another example of the importance of genetic background and the definition of genetic background in trying to perform disease-related studies.
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From page 85... ...
As animal models are developed, I think one has to have the focus on the development of useful disease models, which, in the long run, will be useful both biologically and medically. Because transgenic and recombinant animals and various disease models are generated "in everyone's closet," there has to be a mechanism for deciding which ones are going to be preserved and which ones are going to be lost.
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From page 86... ...
IMPORTANCE OF DISEASE MODELS To illustrate the importance of disease models in a variety of settings, it is necessary to look not only at the importance of understanding the disease processes and their treatments, but also at the translation of research into clinical practice. Two examples follow.
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From page 87... ...
Although I do not impugn anyone's idealistic motivations, in practicality, doing adequate genetic monitoring and adequate microbiological monitoring is expensive, which in turn increases the price of the product and decreases the sales of the product. Thus, there is a built-in thrust against monitoring from the commercial point of view.
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