Biographical Memoirs Volume 77 (1999) / Chapter Skim
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Carl W. Gottschalk
Carl W. Gottschalk
Pages 122-141
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pathophysiologic mechanisms of acute en c! chronic renal disease.
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From page 124... ...
Following his internship, Carl was drafted into the army as a medical officer and was stationed at the Army Medical Research Laboratory in Fort Knox, Kentucky, where he investigated physiological effects of cold exposure in humans. During his travels at that time he assembled a unique collection of Canadian arctic butterflies that now graces the Peabody Museum of Natural History at Yale.
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From page 125... ...
to be changes in renal interstitial pressure, Carl, who was aIreacly interested in carcliology en c! hemoclynamics, began a systematic stucly of renal interstitial pressure using small hypodermic neecIles en c!
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So within a few years, he dedicated himself to bench research en c! began the challenging task of setting up the micropuncture laboratory with little space and less money.
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a $2,000 grant from the Ecigecomb County North Carolina Heart Association. In collaboration with Margaret MyIle, who became his Tong-term associate, he began working in earnest en c!
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Also, by micropuncture they fount! that cluring hyciropenia the concentration of solutes in distal tubular fluid at the surface of the cortex increases from that of a dilute solution at the start of the distal tubule to a concentration similar to systemic plasma (but never higher)
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There was very serious skepticism about the countercurrent theory. When Homer Smith, then the acknowlecigec!
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The data from nine hamsters, one kangaroo rat, and one Psammomys obesus showed virtual equality of osmolaTity in collecting ducts and at the bend of the thin loops of Henle during antidiuresis. This was a technical triumph, providing final decisive evidence for the countercurrent hypothesis.
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the issue conclusively by showing clirectly that the renal nerves affect the rate of salt reabsorption by the tubules. With Elsa Bello-Reuss en c!
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tracer microinjection measurement of tubule permeability (1965) , Andrew Baines en c!
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stage renal disease amendment to
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He was on the eclitorial boards of Physiological Reviews, Circulation Research, American Journal of Physiology, Journal of Applied Physiology, en c! Kidney International.
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The association with Oliver resultec! in Carl's extending his interest in collecting to rare scientific books en c!
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He clonatec! his nearly complete collection of first eclitions of Robert Louis Stevenson to the Rare Books Library of the University of North Carolina in 1997.
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micropuncture experiments that were decisive for establishing principles behinc! urinary concentration, neural control of salt excretion, function of remnant nephrons in failing kidneys, en c!
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Stewart Cameron; a memorial written by William Blythe (In Memoriam, Carl William Gottschalk (1922-1977) , Kidney Int.
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A micropuncture study of the pressures in the proximal tubules and peritubular capillaries of the rat kidney and their relation to ureteral and venous pressure.
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Transtubular electrochemical potentials of sodium and chloride in proximal and distal renal tubules of rats during antidiuresis and water diuresis (diabetes insipidus)
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Hyperoncotic albumin infusion in experimental glomerulonephritis in rats: a micropuncture study.
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