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Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants Volume 4 (2000) / Chapter Skim
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B6 Perfluoropropane and Other Aliphatic Perfluoroalkanes
Pages 137-150

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From page 137...
... According to Russian toxicologists, if all the PFA3 were to escape from the cooling system into the Mir cabin, the cabin concentration could reach 5000 mg/m3 (G.I. Solomina and L.N.
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From page 138...
... Theoretical predictions showed that concentrations of very low water-soluble, volatile compounds in body water would approach steady state within 1 hof exposure (Goldstein 1974~. Metabolism Perfluoroalkanes (PFAs)
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From page 139...
... A survey of the literature on fluorine-containing alkalies reveals that substituting fluorine for chlorine or hydrogen atoms in an FC decreases the compound's toxicity, including cardiac toxicity (Table 6-11. CNS toxicity that could impair cognitive perfo~ance is another concern associated with exposures to high concentrations of relatively biologically inert FCs (e.g., bromotrifluoromethane (ARC 1 984a)
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From page 143...
... for 1 h; neither deaths nor pharmacotoxic signs were observed during the exposure or during the 14-d post-exposure period. Necropsy revealed no gross pathological changes (3M 1993a, 1995c)
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From page 144...
... Clinical chemistry data were unremarkable. Hematological examinations of rats and guinea pigs revealed elevation of total leukocyte counts in some PFA-exposed groups (Table 6-3~.
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From page 145...
... EXPOSURE LIMITS Exposure Limits Set by Other Organizations No exposure limits have been established for any PFAs by any organization in the United States, including 3M, the manufacturer of the products. The Russian Space Agency has set a maximum allowable concentration for PFA3 of 150 mg/m3 (G.r.
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From page 146...
... ACs Based on Cardiac Effects The heart, like the brain, is also a richly and fast-perfused organ. For the reasons presented above, one AC value could be set for all exposure durations.
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From page 147...
... produced neither clinical signs nor microscopic lesions. Using an uncertainty factor of 10 for interspecies variability, ACs for 7 6, 30 0, and T 80 ~ of exposure are set at 1.1% (1 1.3% 10~.
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From page 148...
... 148 ¢ o o · _ C~ o a~ Cd au ¢ V)
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From page 149...
... 1986. A physiologically based simulation approach for determining metabolic constants from gas uptake data.
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From page 150...
... Pp.26-33in Emergency and Continuous Exposure Limits for Selected Airborne Contaminants, Vol 2. Washington, D.C.: National Academy Press.
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Key Terms

  • exposure limits
  • cardiac effects
  • selected airborne
  • microscopic lesions
  • airborne contaminants

  • continuous exposure
  • toxicity summary
  • performance fluid
  • cns effects
  • maximum allowable

  • dogs exposed
  • extremely low
  • brand performance
  • allowable concentrations
  • gross pathological

  • product toxicity
  • clinical chemistry
  • spacecraft maximum
  • initial hyperactivity
  • pathological changes

  • summary sheet
  • rats exposed
  • guinea pigs
  • acs based
  • biologically acceptable

  • cardiac arrhythmias
  • acceptable ranges
  • cardiac toxicity
  • induce cardiac
  • multifocal ectopic


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