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B10 Trichlorofluoromethane (Freon 11)
Pages 211-226

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From page 211... ... Garcia, Ph.D. Johnson Space Center Toxicology Group Medical Operations Branch Houston, Texas PHYSICAL AND CHEMICAL PROPERTIES Trichiorofluoromethane is a colorless, nonflammable liquid or gas at room temperature and has a faint ether-like odor detectable at a threshold concentration of about 5 ppm (ACGTH 1991~. Read the entire page →
From page 212... ... (1972) showed that, although CFC-11 is not significantly metabolized and does not produce free radicals, it exhibits characteristic binding spectra with hepatic microsomal preparations, giving a type I spectrum with a binding constant, Ks, value similar to carbon tetrachioride, Read the entire page →
From page 213... ... (1971) reported ventricular fibrillation and cardiac arrest following injection of epinephrine. Read the entire page →
From page 214... ... In 10 young male volunteers, a 15-s inhalation of 53,000 ppm led to highly significant but "not clinically alarming" reductions of up to about 10% in ventilatory capacity (maximum expiratory flow) lasting about 45 min (Valic et al. Read the entire page →
From page 215... ... � STight tremors progressing to increasingly severe CNS effects up to unconsciousness with increasing concentration or exposure duration beginning at2l,000ppmfor30minupto 106,000 ppmfor2h. � Unconsciousness with occasional weak convulsive movements and audible, irregular breathing at 100,000 to 106,000 ppm for 2 h, and apparent recovery within 2 6, but autopsy ~ ~ after 2-h exposures showed mottled area of resolved congestion or light hemorrhage in lungs (NuckolIs 1933~. Read the entire page →
From page 216... ... There was no evidence of carcinogenicity in either male or female Swiss TCRJHa mice given subcutaneous injections of CFC- 11 in tricaprylin shortly after parturition and observed for the following year. Genotoxicity Negative results for genotoxicity have been obtained for CFC-l l in vitro using bacteria and mammalian cells with or without metabolic activation and in the dominant lethal test (WHO ~ 990~. Read the entire page →
From page 217... ... CFC-! ~ gas was not mutagenic to cultured mammalian cells in the CHO/HGPRT assay (20-200 ,uL/3 mL culture medium, 5 h with and 18-19 h without metabolic activation) Read the entire page →
From page 219... ... 219 o oo oo o an ~ cry ~_ _ I,,, _ _ _ _ ~r _ At r ~ ~ -9 ~ "D . Read the entire page →
From page 220... ... ACGIH 1991 NIOSH's REL Not set ACGTH 1991 NIOSH's STE1L 1000 (ceiling) ACGIH 1991 NRC's 1-h EEGL 1500 NRC 1984 NRC's24-hEEGL 500 NRC 1984 NRCs' 90-d CEGL 100 NRC 1984 STEL, short-term exposure limit; PEL, permissible exposure limit; REL, recommended exposure limit; EEGL, emergency exposure guidance level; CEGL, continuous exposure guidance level. Read the entire page →
From page 221... ... Because no effects were seen in the Stewart experiments even at the highest dose, although a reduced ventilatory capacity was reported by Valic at much higher concentrations of CFC-ll, the ACs calculated below are probably quite conservative. Read the entire page →
From page 222... ... 222 SMA CS FOR SELECTED AIRBORNE CONTAAIINANTS of 10/~/27 = 1.92 for the low number of human subjects was applied. No adjustment was made for exposure duration because the concentration of CFC~ ~ in the brain should parallel the concentration in the blood, which reaches steady state quickly (within 2 hi. Read the entire page →
From page 223... ... 223 so To _ A, CL O U) Read the entire page →
From page 224... ... Pp.1619-1623 in Documentation of the Threshold Limit Values and Biological Exposure Indices, Vol.2, 6th Ed. American Conference of Governmental Industrial Hygienists, Cincinnati, OH. Read the entire page →
From page 225... ... 1984. Emergency and Continuous Exposure Guidance Levels for Selected Airborne Contaminants, Vol. Read the entire page →
From page 226... ... 1975. Studies clarify potential toxicity of aerosol propellants. Read the entire page →

From page 211...

... Garcia, Ph.D. Johnson Space Center Toxicology Group Medical Operations Branch Houston, Texas PHYSICAL AND CHEMICAL PROPERTIES Trichiorofluoromethane is a colorless, nonflammable liquid or gas at room temperature and has a faint ether-like odor detectable at a threshold concentration of about 5 ppm (ACGTH 1991~.

B10 Trichlorofluoromethane (Freon 11) Pages 211-226

B10 Trichlorofluoromethane (Freon 11)
Pages 211-226