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Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons HFC-236fa, HFC-23,and HFC-404a (2000) / Chapter Skim
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Pages 49-49

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... A physiologically based pharmacokinetic mode} was used to simulate blood concentrations of HFC-125 in humans cluring inhalation exposure. The target concentration of HFC-125 in blood was established by simulating a 5-min inhalation exposure at the LOAEL for cardiac sensitization (100,000 ppm)
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Key Terms

  • clinical signs
  • cardiac sensitization
  • inhalation exposure
  • target chemical
  • chemical concentrations

  • blood concentrations
  • based pharmacokinetic
  • locomotor activity
  • decreased locomotor
  • physiologically based

  • auditory response
  • intravenous injection
  • challenge injection
  • blood concentration
  • beagle dogs

  • target concentration
  • simulate blood
  • time courses
  • sensitization thresholds
  • protocols prior


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