(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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, Martijn Roelandse, Caroline Bornmann, and Andrew Matust Friedrich Miescher Institute, 4058 Basel, Switzerland Experimental evidence suggests that microfilaments and microtubules play contrasting roles in regulating the balance between motility and stability in neuronal structures. Actin-containing microfilaments are associated with structural plasticity, both during development when their dynamic activity drives the exploratory activity of growth cones and after circuit formation when the actin-rich dendritic spines of excitatory synapses retain a capacity for rapid changes in morphology.
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sequence (33) into the pTSC vector containing a modified Thy-1 promoter (43~.
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Fig.
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r_ - d~ i~;3 Fig.
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Discussion Our data indicate that the cytoskeleton in neuronal dendrites is partitioned into distinct microtubule and microfilament domains associated with dendrite shafts and spines, respectively. This finding is in contrast to earlier immunocytochemical studies, which reported the presence of MAP2 in dendritic spines (19, 27, 284.
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However, other studies support the idea that dendritic spines are the predomi nant site of activity-dependent morphological plasticity in the brain in vivo (for example, refs.
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10. Letourneau, P
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