(NAS Colloquium) Molecular Kinesis in Cellular Function and Plasticity (2002) / Chapter Skim
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Pages 97-104
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From page 97... ...
We start with a discussion of the functional significance of hippocampal synaptogenesis and then review what is known about the mechanism of synapse formation and the location of ER and their cellular mechanisms of action. The discovery of non-nuclear ER in dendritic spines, presynaptic nerve endings, and spine-associated glial cell processes has led us to propose a testable model for understanding the role of nuclear and non-nuclear ER in synapse formation.
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5~. These findings and those from cell culture studies described below led to a hypothesis regarding the role of interneurons as trans-synaptic regulators of synapse formation.
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Within spines, ERa was often associated with spine apparati and/or postsynaptic densities, suggesting that E might act locally to regulate calcium availability, phosphorylation, and/or protein synthesis (ref.
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We, therefore, discuss the current status of mechanisms of synaptogenesis and the role of protein synthesis. Synapse formation on dendritic spines is a collaborative process involving in-growth of a presynaptic element on a site where a postsynaptic spine is either present or ready to form (32, 7096 1 www.pnas.org/cgi/doi/10.1073/pnas.121146898 61, 62)
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From page 101... ...
Dendritic mRNAs Transport and Protein Synthesis. Protein synthesis is an essential component of de novo synapse formation, and neurons have at least three strategies for activity-dependent regulation of protein synthesis and targeting of those proteins to pre- an-d postsynaptic sites (85, 98-100~: (i)
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Dendrites are sites of protein synthesis on polyribosomes and at endomembrane structures using RNAstransported from the cell body (see text)
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We consider that these postulated actions of E operate syner gistically with the actions of E via nuclear receptors in inter neurons, discussed above, that modulate the inhibitory tone on the CA1 pyramidal neurons where synapse formation occurs. Research support is acknowledged from the National Institutes of Health/National Institute of Neurological Disorders and Stroke (NS 070880)
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From page 104... ...
72. Vician, L., Lim, I
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