Phthalates and Cumulative Risk Assessment The Tasks Ahead (2008) / Chapter Skim
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6 Data Gaps and Research Needs
6 Data Gaps and Research Needs
Pages 138-140
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From page 138... ...
Instead, the research recommended will allow greater refinement of the cumulative risk assessment for all health outcomes associated with phthalates and reduce uncertainty associated with such an assessment. EXPOSURE ASSESSMENT As discussed in Chapter 2, phthalates are used in a wide variety of consumer products and building materials, and widespread exposure of the general population has been documented through the National Health and Nutrition Examination Surveys (NHANES)
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From page 139... ...
TOXICITY ASSESSMENT As discussed in Chapter 3, although few human data are available, rats exposed to a variety of phthalates have exhibited reproductive developmental effects that mirror the hypothesized testicular dysgenesis syndrome in humans. The research initiatives outlined below would add substantially to the scientific database and enable better prediction of effects of phthalate exposure.
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From page 140... ...
Furthermore, as EPA moves toward cumulative risk assessment, some consideration should be given to restructuring IRIS so that its process for identifying chemicals for review includes and sets priorities among chemical mixtures, as appropriate, and facilitates cumulative risk assessment conducted by using common adverse outcomes. For example, listing the noobserved-adverse-effect levels or benchmark doses for a variety of effects would facilitate that approach.
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