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Facilitating Collaborations to Develop Combination Investigational Cancer Therapies Workshop Summary (2012) / Chapter Skim
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6 Financial Challenges
Pages 53-54

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From page 53...
... Raising funds is a very large challenge and the NCI grants don't cover these kinds of trials. It requires multiple kinds of support from grants, foundations, and philanthropy." He pointed out that cell therapies are not necessarily more expensive than antibody therapies 1 A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA, in order to better understand how a similar gene may cause or contribute to disease in humans.
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From page 54...
... Right now, patients are often getting antibodies for their lifespan. If you have a selfreplicating cell that can continue to make antibodies, the cells may actually in the end be more cost-effective," Dr.
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Key Terms

  • june noted
  • standard grants
  • trial costs
  • prohibitively expensive
  • provide funding

  • growing importance
  • validating assays
  • selection assays
  • rna libraries
  • stern noted

  • patient selection
  • clinical trial
  • dard clinical
  • investigators rely
  • selfreplicating cell

  • cell therapies
  • requires multiple
  • antibody therapies
  • federal government
  • multiple kinds

  • existing gene
  • knockout mouse
  • artificial piece
  • similar gene
  • laboratory mouse

  • getting antibodies
  • raising funds
  • national institutes
  • nci grants


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