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Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 132-135

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From page 132...
... We exploit this recursion more fully in the section below on likelihood methods. The Finitely-Many-Sites Models We now have the machinery necessary to describe the finitely-many-sites model for molecular sequence data involving n sequences, each of s sites.
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From page 133...
... In particular, the number Sn Of segregating sites has mean EtSn] = sP(siteis segregating)
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From page 134...
... ) x This moment estimator makes biller use of the data than the estimate based on the number of segregating sites.
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From page 135...
... At this point, we have come to our mathematical vignette, where population genetics theory intersects with an interesting area in combinatorics. The mathematical level of the vignette is somewhat higher than our discussion of the coalescent; readers primarily interested in aspects of the coalescent might feel justified in skipping to the final section.
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Key Terms

  • population genetics
  • segregating sites
  • population size
  • substitution rates
  • mutation occurs

  • sequence data
  • coalescent tree
  • likelihood methods
  • mathematical vignette
  • poisson process

  • mutation rates
  • substitution rate


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