Calculating the Secrets of Life:

Contributions of the Mathematical Sciences to Molecular Biology

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Size: 300 pages, 6 x 9

Publication Year:1995

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PAPERBACK ISBN-10: 0-309-07502-5 ISBN-13: 978-0-309-07502-2	$78.00	Add to Cart

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Authors:
Eric S. Lander and Michael S. Waterman, Editors; Committee on the Mathematical Sciences in Genome and Protein Structure Research, National Research Council
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As researchers have pursued biology's secrets to the molecular level, mathematical and computer sciences have played an increasingly important role--in genome mapping, population genetics, and even the controversial search for "Eve," hypothetical mother of the human race.
In this first-ever survey ...
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Table of Contents
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Front Matter	i-xiv
1 The Secrets of Life: A Mathematician's Introduction to Molecular Biology	1-24	(skim)
2 Mapping Heredity: Using Pobabilistic Models and Algorithms to Map Genes and Genomes	25-55	(skim)
3 Seeing Conserved Signals: Using Algorithms to Detect Similarities Between Biosequences	56-89	(skim)
4 Hearing Distant Echoes: Using Extremal Statistics to Probe Evolutionary Origins	90-113	(skim)
5 Calibrating the Clock: Using Stochastic Processes to Measure the Rate of Evolution	114-152	(skim)
6 Winding the Double Helix: Using Geometry, Topology, and Mechanics of DNA	153-178	(skim)
7 Unwinding the Double Helix: Using Differential Mechanics to Probe Conformational Changes in DNA	179-201	(skim)
8 Lifting the Curtain: Using Topology to Probe the Hidden Action of Enzymes	202-235	(skim)
9 Folding the Sheets: Using Computational Methods to Predict the Structure of Proteins	236-271	(skim)
Appendix: Chapter Authors	272-276	(skim)
Index	277-286	(skim)

Description

As researchers have pursued biology's secrets to the molecular level, mathematical and computer sciences have played an increasingly important role--in genome mapping, population genetics, and even the controversial search for "Eve," hypothetical mother of the human race.
In this first-ever survey of the partnership between the two fields, leading experts look at how mathematical research and methods have made possible important discoveries in biology.
The volume explores how differential geometry, topology, and differential mechanics have allowed researchers to "wind" and "unwind" DNA's double helix to understand the phenomenon of supercoiling. It explains how mathematical tools are revealing the workings of enzymes and proteins. And it describes how mathematicians are detecting echoes from the origin of life by applying stochastic and statistical theory to the study of DNA sequences.
This informative and motivational book will be of interest to researchers, research administrators, and educators and students in mathematics, computer sciences, and biology.

Calculating the Secrets of Life:

Contributions of the Mathematical Sciences to Molecular Biology

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