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Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 35-36

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From page 35...
... One can then calculate ~ by numerical maximization methods. To A determine whether ~ is significantly different from a null value 00 (for example, to see whether an estimated recombination frequency is significantly less than 50 percent)
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From page 36...
... developed an alternative algorithm based on hidden Markov models for nesting the sum according to the genetic markers used, starting with markers at one end of the map and working across to the other end. These authors also exploited the expectation-max~mization algorithm from statistics (a well-known maximum likelihood approach)
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Key Terms

  • recombination frequency
  • genetic markers
  • genetic linkage
  • maximum likelihood


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