Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 241-247
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From page 241... ...
Because direct computation is difficult, one approach would be to look for patternsand regularities in protein structures that might simplify the task of prediction. In fact, considerable insight can be gained by simply looking at experimentally detemiined protein structures.
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Only 52 finds the global minimum. Observes that proteins tend to employ certain stereotypical local conformations called secondary structures.
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Folding the Sheets 6 ~-it .
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Molecular biologists have borrowed the term "topology" (inappropriately) to describe the path that the chain takes in joirung consecutive secondary structure elements.
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In summary, the analysis of protein structures has produced some unassailable conclusions: pacldng is an important element of protein stability; secondary structure is a common component of protein structure;
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Folding the Sheets 247 .
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