Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
Currently Skimming:
Pages 163-165
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 163... ...
As we noted above, a relaxed DNA molecule of monkey virus SV40 with about 5,250 base pairs has Lko = Tw = 500 . However, the linking number of most closed circular DNA is not that of the relaxed state.
|
From page 164... ...
, enzymes were found that can actually change the linking number difference and in fact change a highly supercoiled DNA into a relaxed open circular DNA (Wang, 1985~. These enzymes, called topoisomerases, because they change the topology of the DNA, are dividec!
|
From page 165... ...
Interestingly enough, the same DNA with different linking number differences can be separated by means of gel electrophoresis (Wang and Bauer, 1979~. Separation occurs due to the fact that such DNA travel through the tangled molecular matrix of a gel at different speeds because one has more Wr ant!
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.