Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 37-41
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From page 37... ...
showed that FAP was genetically linked to a region on the Tong arm of human chromosome 5; subsequently, physical mapping studies led to the isolation of the responsible gene, named APC (Groden et al., 1991; Kinzler et al., 1991; Nishisho et al., 1991)
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From page 38... ...
The Min mouse thus provided a mode! of human colon cancer and, in particular, a way to look for other genes that might suppress the development of colon tumors.
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. B6-Min BC1 F1 FIGURE 2.4 Distribution of colon tumors caused by the Min mutation.
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the problem is slightly more complicated because one can only observe the genotype at the location of the DNA polymorphisms studied. However, for this discussion, the map can be assumed to be so dense that the data are essentially continuous.
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From page 41... ...
and each Xi < X2 < < Xn ~ the random variables Ztx~ )
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