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Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 222-224

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From page 222...
... ) =< 2 > THE TANGLE MODEL FOR SITE-SPECIFIC RECOMBINATION The fundamental observations underlying this model are that a pair of sites bound by an enzyme forms a tangle and that most of the products of recombination experiments performed on unknotted substrate are 4
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From page 223...
... w e Will use tangles to build a model that will compute the topology of the pre- and post-recombination synaptic complex in a single recombination event, given knowledge of the topology of the substrate and product (Ernst and Sumners, 1990; Sumners, 1990, 1992; Sumners et al., 1994~. In site-specific recombination on circular DNA substrate, two kinds of geometric manipulation of the DNA occur.
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From page 224...
... other DNA bound to the enzyme, which is unchanged during a recombination event; and (3) the DNA in the synaptic complex that is not bound to the enzyme and that does not change dunug recombination.
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Key Terms

  • synaptic complex
  • enzyme mechanism
  • recombination event
  • dna substrate
  • single recombination

  • tangle model
  • enzyme action
  • recombination sites
  • recombinant tangle
  • tangle closure

  • recombination site
  • circular dna
  • enzyme ball
  • observed changes
  • distant recombination

  • parental tangle
  • tangle addition
  • entire synaptic


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