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Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 254-254

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From page 254...
... The precise cross-linking of the polypeptide chain through disulfide bridges or other chemical reagents provides distance constraints that connect sequentially distant regions of the chain. To a lesser extent, sitedirected mutagenesis, which detects the impact of changes to the amino acid sequence on protein stability and function, and limited proteolysis experiments, which detect the relative accessibility of regions of the chain, can provide useful constraints to sort between alternative mode!
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Key Terms

  • protein structure
  • amino acid
  • electrostatic interactions
  • sequentially distant
  • disulfide bridges

  • existing potential
  • acid sequence


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