Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 27-29
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To understand the foundation of genetic mapping, it is useful to return to the work of Gregor Mendel. Based on his experiments with peas (see Chapter 1)
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Genetic mapping is based on the recognition that the recombination frequency O between two genes (or loci) provides a measure of the distance between them.
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From page 29... ...
to be ~ (i -2d ~ / 2 This equation, relating recombination frequency to genetic distance, is known as Haidane's mapping function. For small distances, the formula reduces to ~ ~ 4, which reflects the fact that the possibility of more than one crossover can be neglected.
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