Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 90-93
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From page 90... ...
What threedimensional shape will the linear amino acid sequence of a protein assume when it folds up according to the laws of thermodynamics? Another class of questions concerns the evolutionary relationships between known sequences.
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From page 91... ...
Sequence comparison is of tremendous interest to molecular biologists because it is becoming easy to determine DNA ant! protein sequences, whereas it remains difficult to determine molecular structure or Unction by experimental means.
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From page 92... ...
rRNAs are components of the macromolecular structure, called the ribosome, used for translating RNA sequences into protein sequences. tRNAs are the "adapter molecules" that read the genetic code, with an anticodon loop recognizing a particular codon at one end and an attachment site for the amino acid corresponding to this codon at the other.
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From page 93... ...
If the score distribution is consistent with that from comparison of random sequences, we would fad! to reject the statistical hypothesis and thus have evidence against the biological hypothesis.
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