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Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 192-193

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From page 192...
... However, their accuracy can be estimated by comparing the corrected ensemble average number of separated base pairs with its (uncorrectecl) value that is computed as the sum of the probabilities of separation for all base pairs in the sequence.
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From page 193...
... In consequence, this transition is favored only when the DNA is significantly supercoiled. This is shown in Figure 7.2, where the solid line depicts the probability of strand separation in pBR322 DNA (N= 4,363 base pairs)
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Key Terms

  • strand separation
  • free energy
  • base pair
  • strand separations
  • base pairs

  • separated base
  • energy parameters
  • ensemble average
  • negative superhelicity
  • interstrand twisting


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