Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 181-183
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From page 181... ...
For simplicity we consider a closed circular duplex DNA molecule as the paradigm of the topological domain. (Closed circles are also the molecules of choice for experiments in this field.)
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From page 182... ...
Since strand separations require energy, they are disfavored in unconstrained or relaxed molecules. However, in a negatively superhelical domain, local strand separations are energetically favored to occur at equilibrium whenever the topological strain energy that is thus relieved exceeds the energetic cost of locally disrupting the base pairing between strands.
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From page 183... ...
The DNA sequence at this origin site contains a triple repeat of an A+T-rich run of 13 base pairs that is required for the initiation of DNA replication. Deletion and substitution experiments have shown that the key functional attribute of this sequence is its susceptibility to superhelical strand separation.
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