Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 30-33
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for both human diseases and animal models of these diseases, the trait may not be simply related to the genotype at a single gene. Owing to these complications, genetic mapping of disease genes often requires sophisticated mathematical analysis.
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, and thus human genetic mapping remained a dormant field. In 1980, David Botstein set off a revolution by recognizing that naturally occurring DNA polymorphisms in the human population filled the need (Botstein et al., 1980~.
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32 CALCULATING THE SECRETS OF LIFE A b ca x + ++ Offspring Genotypes Number (1)
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The first two types of progeny involve chromosomes with no recombination; the next four involve a single recombination, and the last two involve double recombination (between C-A and A-D)
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