Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Excursion: Designing a Strategy to Map the Human Genome Under the auspices of the Human Genome Project, our laboratory is engaged in constructing complete physical maps of the mouse and human genomes, each about 3x109 base pairs in length. The task is daunting, requiring analysis of tens of thousands of clones, each carrying extremely large DNA fragments.
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the length of the genome in base pairs; L, the length of a random clone in base pairs, a random variable; L, the expected length of a random clone, L = E(L)
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Instead, it is more sensible to focus on central behavior that is, the goal of covering most of the space. STS content mapping poses a slightly unusual coverage problem, because the definition of coverage involves joining together random intervals with random points.
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From these graphs, expenmentaTists can plan their experimental approach. For our own physical mapping project in the human genome, the typical clone size is about 1 x 106 base pairs.
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