Calculating the Secrets of Life Contributions of the Mathematical Sciences to Molecular Biology (1995) / Chapter Skim
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Pages 174-176
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From page 174... ...
APPLICATION TO THE STUDY OF THE MINICHROMOSOME A minichromosome is a structure that consists of a closed DNA bound to a series of core nucleosomes. Such a structure allows the compaction of a very Tong DNA into a small volume, in the same way that a Tong piece of thread is compacted by wrapping it on a spool.
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From page 175... ...
Such a relaxed state can be achieved by the introduction into the minichromosome of topoisomerases, which relax the linker DNA but leave unaffected the DNA on the nucleosome cores. In this case, SLk can be directly measured by X-ray diffraction and found to be -1.S m, where m is the number of nucleosomes.
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From page 176... ...
The nucleosomes are connected by linker DNA segments. Successive real nucleosomes are connected by virtual deformed cylindrical pieces, the deformations of which are determined by the coiling of the linker.
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