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Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

C
SURVEY RESULTS

TABLE C-1 Banks That Responded

Bank

State

American Red Cross North Central Blood Services Cord Blood Program

MN

Carolinas Cord Blood Bank

NC

Children’s Hospital of Orange County Cord Blood Bank

CA

Cord Blood Registry

CA

Cryobanks International, Inc.

FL

ITxM Cord Blood Services

IL

JP McCarthy Cord Stem Cell Bank

MI

Lifebank USA

NJ

LifeCord

FL

LifeStor

VA

Michigan Community Blood Centers Cord Blood Bank

MI

National Cord Blood Program of the New York Blood Center

NY

New Jersey Cord Blood Bank

NJ

Puget Sound Blood Center and Hawaii Cord Blood Bank

WA

Sibling Donor Cord Blood Program Children’s Hospital Oakland Research Institute

CA

South Texas Blood & Tissue Center

TX

St. Louis Cord Blood Bank

MO

StemCyte International Cord Blood Center and Cord Blood Family Trust

CA

The Elie Katz Umbilical Cord Blood Program

NJ

University of Colorado Cord Blood Bank

CO

Viacord

MA

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-2 Type of Bank

PUBLIC BANKS

American Red Cross North Central Blood Services Cord Blood Program

JP McCarthy Cord Stem Cell Bank

Michigan Community Blood Centers Cord Blood Bank

National Cord Blood Program of the New York Blood Center

New Jersey Cord Blood Bank

South Texas Blood & Tissue Center

St. Louis Cord Blood Bank

University of Colorado Cord Blood Bank

PRIVATE BANKS

Cord Blood Registry

LifeStor

Sibling Donor Cord Blood Program Children’s Hospital Oakland Research Institute

Viacord

BANKS THAT OFFER BOTH

Carolinas Cord Blood Bank

Children’s Hospital of Orange County Cord Blood Bank

Cryobanks International, Inc.

ITxM Cord Blood Services

Lifebank USA

LifeCord

Puget Sound Blood Center and Hawaii Cord Blood Bank

StemCyte Inc. and Cord Blood Family Trust

The Elie Katz Umbilical Cord Blood Program at Community Blood Services

Totals: 8 Public, 4 Private, 9 Mixed

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-3 Self-Reported Accreditationa

Bank

FACT

AABB

Otherb

American Red Cross North Central Blood Services Cord Blood Program

 

X

 

Carolinas Cord Blood Bank

X

 

FACT pending, NMDP

Children’s Hospital of Orange County Cord Blood Bank

X

 

JCAHO, California Tissue Bank License, Seeking FACT Accreditation

Cord Blood Registry

 

X

 

Cryobanks International, Inc.

 

X

 

ITxM Cord Blood Services

 

 

Will apply for FACT this fall

JP McCarthy Cord Stem Cell Bank

 

 

NMDP

Lifebank USA

 

X

ISO

LifeCord

X

X

NMDP

Michigan Community Blood Centers Cord Blood Bank

 

X

FDA Registration

National Cord Blood Program of the New York Blood Center

X

 

New York State Board of Health

New Jersey Cord Blood Bank

 

 

 

Puget Sound Blood Center and Hawaii Cord Blood Bank

 

X

 

Sibling Donor Cord Blood Program Children’s Hospital

Oakland Research Institute

X

 

California State Biologies, California State Tissue Bank (both current)

St. Louis Cord Blood Bank

 

X

CAP

StemCyte, Inc. and Cord Blood Family Trust

 

X

ASHI, NMDP, CAP, California Biologics License, CLIA, FACT pending

The Elie Katz Umbilical Cord Blood Program

 

X

 

University of Colorado Cord Blood Bank

X

 

 

Viacord

 

X

CLIA, CAP proficiency, NY State, NJ State, KY State, PA State, registered with FDA and IL State, and MD tissue bank permit

aThe accreditation status of the banks was not independently verified.

bThe definitions of the acronyms are provided at the end of this appendix.

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-4 Numbers of Collected, Stored, and Transplanted Units

Bank

Consenting to Collect

Collected

Banked

Available

Searchable

Used for Transplant

Note

American Red Cross North Central Blood Services Cord Blood Program

23,130

18,680

6,069

5,962

5,962

242

8 not transplanted

Carolinas Cord Blood Bank

17,519

17,000

8,300

7,800

7,800

320

 

Children’s Hospital of Orange County Cord Blood Bank

3390

2,900

1,550

1,375

1,350

7

 

Cryobanks International, Inc.

17,741

15,429

9,439

7,485

7,485

5

4 public, 1 private

ITxM Cord Blood Services

9,867

5,280

5,000

2,620

2,513

20

Consenting refers to collection kits requested

JP McCarthy Cord Stem Cell Bank

3323

2,486

600

517

445

4

 

Lifebank USA

17,807

17,228

16,264

3,300

3,300

1

 

LifeCord

1

7,429

1,975

1,474

1,474

10

 

LifeStor

102

96

 

Michigan Community Blood Centers Cord Blood Bank

6,665

5,531

1,497

1,386

1,375

6

 

National Cord Blood Program of the New York Blood Center

27,328

29,525

25,989

25,989

25,989

1,765

Includes first and second transplantations and multiple-unit grafts

New Jersey Cord Blood Bank

 

2,621

1,984

1,796

1,796

7

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Bank Name

Consenting to Collect

Collected

Banked

Available

Searchable

Used for Transplant

Note

Puget Sound Blood Center and Hawaii Cord Blood Bank

3,877

2,358

1,097

727

727

5

 

Sibling Program Children’s Hospital Oakland Research Institute

1,556

1,438

1,378

1,064

0

43

 

St. Louis Cord Blood Bank

40,000

40,000

10,000

10,000

10,000

656

10,000 means >10,000. Searches include NMDP, CRIR, and direct searches. Transplants are through June 30, 2004

StemCyte, Inc. and Cord Blood Family Trust

16,777

13,566

8,558

8,331

8,331

78

 

The Elie Katz Umbilical Cord Blood Program

 

3,635

2,473

2,473

1,511

25

 

University of Colorado Cord Blood Bank

10,000

9,943

7,017

6,669

6,435

234

Total consenting not known with precision

Viacord

60,000

60,000

 

 

0

14

60,000 means >60,000. Every consent resulted in a collection.

Total

259,083

255,145

109,190

62,979

60,504

3,384

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

FIGURE C-1 Total units collected, by bank.

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-5 Banks That Are Currently Collecting Units

Bank

American Red Cross North Central Blood Services Cord Blood Program

Carolinas Cord Blood Bank

Children’s Hospital of Orange County Cord Blood Bank

Cord Blood Registry

Cryobanks International, Inc.

ITxM Cord Blood Services

JP McCarthy Cord Stem Cell Bank

Lifebank USA/Anthrogenesis Corp.

LifeCord

Michigan Community Blood Centers Cord Blood Bank

National Cord Blood Program of the New York Blood Center

New Jersey Cord Blood Bank

Puget Sound Blood Center and Hawaii Cord Blood Bank

Sibling Program Children’s Hospital Oakland Research Institute

St. Louis Cord Blood Bank

StemCyte, Inc. and Cord Blood Family Trust

The Elie Katz Umbilical Cord Blood Program

Viacord

FIGURE C-2 Available units—across all banks.

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-6 Racial Makeup of Inventory

 

Percent Available

Asian

African American

Hispanic

Native American

Middle Eastern

Caucasian

Unknown

Multiracial

Other

Averages by total number of units

5.79

11.60

16.81

1.02

0.11

56.08

4.89

3.01

0.69

BY BANK

American Red Cross North Central Blood Services Cord Blood Program

2.47

6.59

12.03

0.37

 

64.64

13.90

 

 

Carolinas Cord Blood Bank

2.21

19.52

9.26

0.14

0.00

59.15

0.02

9.21

0.50

Children’s Hospital of Orange Country Cord Blood Bank

17.70

0.67

35.40

2.67

 

43.55

0.00

0.00

0.00

Cryobanks International, Inc.

1.92

8.06

11.16

1.12

0.57

67.24

0.28

9.65

 

ITxM Cord Blood Services

3.72

2.16

5.58

1.38

0.00

86.46

 

0.43

0.26

JP McCarthy Cord Stem Cell Bank

0.45

80.67

2.25

0.22

 

6.52

 

9.66

0.22

LifeCord

0.83

3.32

2.76

0.00

0.41

82.72

 

9.95

 

Michigan Community Blood Centers Cord Blood Bank

1.17

2.20

3.03

1.38

 

64.19

28.03

 

 

National Cord Blood Program of the New York Blood Center

7.70

21.00

21.10

 

 

45.60

4.60

 

 

New Jersey Cord Blood Bank

2.17

7.24

0.50

0.89

0.39

61.41

 

 

27.39

Puget Sound Blood Center and Hawaii Cord Blood Bank

33.01

1.79

4.54

4.26

 

56.40

 

 

 

St. Louis Cord Blood Bank

0.66

1.59

0.28

4.69

 

84.35

0.94

7.50

 

StemCyte, Inc. and Cord Blood Family Trust

14.99

4.00

51.01

0.39

 

27.00

2.62

 

 

The Elie Katz Umbilical Cord Blood Program

2.02

2.95

10.96

0.08

1.05

42.74

40.19

0.00

0.00

Averages by bank

6.50

11.55

12.13

1.35

0.41

56.57

10.06

5.80

4.73

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-7 Criteria to Determine Which Units Are Suitable for Banking

Bank

Threshold of Nucleated Cell Dose

Volume

Bacterial Contamination (Negative)

American Red Cross North Central Blood Services Cord Blood Program

Preprocessing TNC of 1.2 × 109

50 ml

X

Carolinas Cord Blood Bank

9 × 108

60 ml

X

Children’s Hospital of Orange County Cord Blood Bank

9 × 108

40 ml minimum

X

Cryobanks International, Inc.

Precount >8 × 108

60 g

X

ITxM Cord Blood Services

 

40 ml collection per NMDP IND

X

JP McCarthy Cord Stem Cell Bank

 

 

X

Lifebank USA

TNC = 5 × 108

35 ml

X

LifeCord

8 × 108 TNC preprocessing

≥40 ml

 

Michigan Community Blood Centers Cord Blood Bank

11 × 108, minority threshold = 9.5 × 108

45 ml

X

National Cord Blood Program of the New York Blood Center

9 × 108

 

X

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Level of HLA Resolution

Other

 

Donation is excluded if:

  • unit is reactive for infectious disease markers

  • unit has less than 70 percent postprocessing and prefreezing viability

  • there is a family history of diseases, conditions, and/or genetic disorders that may affect the recipient

  • the mother has symptoms of or has been diagnosed with certain infectious diseases including West Nile virus, parasitic blood diseases, syphilis, hepatitis, and HIV/AIDs

  • the mother has engaged in behaviors or received medical treatments that increase the risk of contracting these diseases

Intermediate resolution for Class I HLA, highresolution DRB1

Tests negative for homozygous hemoglobinopathies; positive CFU growth

Negative infectious disease testing on maternal blood

 

Negative maternal infectious disease markers, processed within 36 hours of collection

 

Maternal and baby health questionnaire eligibility Infectious disease testing, microbiology testing, hemaglobinopathy screen, viability

 

Infectious disease markers, ABO and RH type determination of cord blood unit, newborn screening retention samples, maternal medical health questionnaire, review of maternal and newborn medical records

 

Virology negative (except for CMV)

 

Negative infectious disease test results, lack of family medical history of inherited genetic disorders or diseases, no inappropriate affirmative responses to questions from risk behavior questionnaire

 

Negative infectious disease testing, normal genetic screen “We also apply the same deferral criteria as that of whole blood donors for risk factors”

Class I antigen level (molecular test, SSP)

No evidence of viral infection for HIV/HILV-1/11, hepatitis B or C virus, CMV by culture or DNA PCR testing.

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Bank

Threshold of Nucleated Cell Dose

Volume

Bacterial Contamination (Negative)

New Jersey Cord Blood Bank

minimum of 1.5 × 108 preprocessing, 1.2 × 108 postprocessing

>40 ml of cord blood

X

Puget Sound Blood Center and Hawaii Cord Blood Bank

9 × 108

40 ml

 

Sibling Program Children’s ≤ Hospital Oakland Research Institute

3 × 108

≤20 cc

 

St. Louis Cord Blood Bank

>8.0 × 108

45 ml

X

StemCyte, Inc. and Cord Blood Family Trust

 

50 ml public, 10 ml private

X

The Elie Katz Umbilical Cord Blood Program

4 × 108 TNC for autologous storage and 6 × 108 TNC for allogeneic

if less than 50 ml then check TNC

X

University of Colorado Cord Blood Bank

TNC greater than 109*

≥95 ml collected*

X

Viacord

100 × 106 TNC

≥10 ml

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Level of HLA Resolution

Other

HLA-A HLA-B, and DRB1 intermediate resolution

Maternal health history, maternal infectious disease screening, 6-month and 1-year follow-up of child’s health

 

Complications and/or congenital abnormalities observed

 

Since units are all related, we bank as many as possible

 

CD34+ and CF4 values, viability

Intermediate-resolution HLA-A and HLA-B, highresolution DRB1

Infectious disease markers (only positives banked are CMV and Hepatitis B core), maternal health history and family genetic history

 

Negative viral marker results

HLA-A, HLA-B serological equivalent, HLA-DRB1 high resolution

Negative infectious disease markers, no risk factors from maternal donor questionnaire, complete consent Criteria with “*” are to be used for qualifying future collections

 

CD34, viability <50 percent, positive HIV status of mother, units with other abnormal infectious disease results stored only after a review by medical director

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-8 Criteria Used to Determine Which Units Are for Transplant

 

Criteria for a Transplant Center Before Receiving Units from Bank

Bank

NMDP Approved Site

FACT Accreditation

Other

American Red Cross North Central Blood Services Cord Blood Program

 

 

Evidence of IRB approval (or international equivalent); evidence of NMDP, FACT, or equivalent certification; agreement to provide outcome data

Carolinas Cord Blood Bank

X

 

Use IRB approved protocols

Children’s Hospital of Orange County Cord Blood Bank

X

 

 

Cryobanks International, Inc.

X

 

Meet WMDA recommendations for transplant center criteria

ITxM Cord Blood Services

X

 

 

JP McCarthy Cord Stem Cell Bank

X

 

 

Lifebank USA

 

 

IRB approved protocol, agreeing to provide post-transplant data

LifeCord

X

 

 

Michigan Community Blood Centers Cord Blood Bank

 

 

IRB approved transplant protocol

National Cord Blood Program of the New York Blood Center

 

 

Must have a recognized track record in BMT, and accreditation by EBMT, JACIE, etc.

New Jersey Cord Blood Bank

X

 

Written prescription from transplant center

Puget Sound Blood Center and Hawaii Cord Blood Bank

X

 

Signed agreement and memorandum of understanding

St. Louis Cord Blood Bank

 

 

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

 

How Bank Is Most Commonly Accessed by Transplant Center

Transplant Center Exceptions

Direct Contact

NET-CORD

NMDP

Other

Exceptions allowed on basis of approval by medical director

X

 

 

 

Medical director has personal knowledge of transplant center

X

 

X

parents or referring physician

N/A

 

 

X

 

Medical director approval

 

 

 

CRIR

Private family units do not need to go to NMDP centers

X

 

X

 

NMDP will permit compassionate-use requests for nonmember transplant centers

 

 

X

 

 

 

 

 

BMDW

 

 

 

X

 

 

X

 

 

CRIR

 

X

X

 

 

 

 

 

X

 

 

 

 

X

CRIR

 

X

 

X

CRIR

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

 

Criteria for a Transplant Center Before Receiving Units from Bank

Bank

NMDP Approved Site

FACT Accreditation

Other

StemCyte, Inc. and Cord Blood Family Trust

X

 

For most non-U.S. transplant centers, this does not apply

The Elie Katz Umbilical Cord Blood Program

 

 

IRB, if available, request form

University of Colorado Cord Blood Bank

 

 

Must meet WMD recommendations and requirements per Goldman et al., 1994, A special report: Bone marrow transplants using volunteer donors—recommendaions and requirements for a standardized practice throughout the world. Blood 84:2833.

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

 

How Bank Is Most Commonly Accessed by Transplant Center

Transplant Center Exceptions

Direct Contact

NET-CORD

NMDP

Other

 

 

 

X

CRIR

Foreign countries

X

 

 

BMDW

Compassionate use

X

 

 

CRIR, various foreign national registries

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-9 Units That Are Not Usable for Transplant

 

Research–External

Bank

Research/Internal

Discarded or Destroyed

Investigator Charged

No Charge

American Red Cross North Central Blood Services Cord Blood Program

X

X

X

X

Carolinas Cord Blood Bank

X

X

X

X

Children’s Hospital of Orange County Cord Blood Bank

X

X

 

 

Cryobanks International, Inc.

X

X

 

X

ITxM Cord Blood Services

X

X

 

X

JP McCarthy Cord Stem Cell Bank

 

X

 

X

Lifebank USA

X

 

 

X

LifeCord

X

X

 

X

Michigan Community Blood Centers Cord Blood Bank

 

X

 

 

National Cord Blood Program of the New York Blood Center

X

X

X

X

New Jersey Cord Blood Bank

X

X

 

 

Puget Sound Blood Center and Hawaii Cord Blood Bank

X

X

 

 

St. Louis Cord Blood Bank

X

X

 

X

StemCyte, Inc. and Cord Blood Family Trust

X

X

X

X

The Elie Katz Umbilical Cord Blood Program

X

X

 

X

University of Colorado Cord Blood Bank

X

X

X

X

Viacord

X

X or continue storage

 

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-10 Are Units Bar Coded and Tracked Electronically? If Not, How Are They Tracked?

Bank

Tracking of Units

American Red Cross North Central Blood Services Cord Blood Program

Units are labeled with unique, bar-coded identifiers. All paperwork and corresponding samples are labeled with the unique identifier associated with the unit. A database is used to monitor the location of the unit and inspection and testing status.

Carolinas Cord Blood Bank

Yes. Units are bar coded with the ISBT 128 system.

Children’s Hospital of Orange County Cord Blood Bank

Yes, bar coded and tracked

ITxM Cord Blood Services

Bar coded, tracked in database

LifeCord

Yes

Michigan Community Blood Centers Cord Blood Bank

Manual entry into database

National Cord Blood Program of the New York Blood Center

Yes

New Jersey Cord Blood

Yes Bank

Puget Sound Blood Center and Hawaii Cord Blood Bank

Yes; bar coded; also, the location is recorded in the unit chart

Sibling Program Children’s Hospital Oakland Research Institute

Units are bar coded and tracked electronically and manually; a written inventory log is kept

St. Louis Cord Blood Bank

Yes

StemCyte, Inc. and Cord Blood Family Trust

Yes

The Elie Katz Umbilical Cord Blood Program

Yes

University of Colorado Cord Blood Bank

Yes (for cord blood unit banked after July 1999, 68 percent of searchable inventory)

Viacord

Bar code from collection of cord blood through transport to receipt at lab. Manual tracking from receipt to storage (and distribution if called on)

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-11 Informatics

Bank

Excel Spreadsheet

Access Database

Other Database

American Red Cross North Central Blood Services Cord Blood Program

X

X

Oracle Database

Carolinas Cord Blood Bank

 

X

EMMES

Children’s Hospital of Orange County Cord Blood Bank

 

 

CordLink NMDP

Cryobanks International, Inc.

 

X

 

ITxM Cord Blood Services

 

X

NMDP CordLink

JP McCarthy Cord Stem Cell Bank

 

X

 

Lifebank USA

X

 

Stem Lab Software

LifeCord

 

 

Oracle

Michigan Community Blood Centers Cord Blood Bank

X

X

 

National Cord Blood Program of the New York Blood Center

 

 

Oracle

New Jersey Cord Blood Bank

 

 

Sybase and CordLink

Puget Sound Blood Center and Hawaii Cord Blood Bank

 

X

Cordlink

Sibling Program Children’s Hospital Oakland Research Institute

X

 

SQL database

St. Louis Cord Blood Bank

 

X

SQL server

StemCyte, Inc. and Cord Blood Family Trust

X

X

 

The Elie Katz Umbilical Cord Blood Program

X

X

 

University of Colorado Cord Blood Bank

 

X

 

Viacord

X

X

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-12 Collection and Storage: Who Does the Collection

Bank

Obstetrician/Midwife

Obstetrical Nurse

Designated Collector from the CBB

American Red Cross North Central Blood Services Cord Blood Program

X

 

X

Carolinas Cord Blood Bank

X

 

X

Children’s Hospital of Orange County Cord Blood Bank

 

 

X

Cryobanks International, Inc.

X

X

 

JP McCarthy Cord Stem Cell Bank

 

 

X

Lifebank USA

X

X

 

LifeCord

X

X

X

Michigan Community Blood Centers Cord Blood Bank

X

X

 

National Cord Blood Program of the New York Blood Center

 

 

X

New Jersey Cord Blood Bank

X

X

X

Puget Sound Blood Center and Hawaii Cord Blood Bank

X

X

 

Sibling Program Children’s Hospital Oakland Research Institute

X

X

 

St. Louis Cord Blood Bank

X

 

 

StemCyte, Inc. and Cord Blood Family Trust

X

X

X

The Elie Katz Umbilical Cord Blood Program

X

X

X

University of Colorado Cord Blood Bank

X

X

X

Viacord

X

X

X

NOTE: No banks answered “Researcher” or “other.”

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-13 Exclusion Criteria

Bank

Multiple Gestations

Gestational Age of Less Than ______ Weeks

Chorioamnionitis (Definition at This Center)

Prolonged Rupture of Membranes (Without Chorioamnionitis)

Tear in Cord Insertion from Placenta

American Red Cross North Central Blood Services Cord Blood Program

X

X

Evaluation of infection is performed by the cord blood bank through chart review

 

 

Carolinas Cord Blood Bank

X

34

Inflammation of the chorion and the amnion, the membranes that surround the fetus

 

 

Children’s Hospital of Orange County Cord Blood Bank

 

36

 

 

X

Cryobanks International, Inc.

 

 

 

 

 

ITxM Cord Blood Services

X

36

Evidence of infection or odor, pus, temperature >38.5.°­C

 

X

JP McCarthy Cord Stem Cell Bank

 

 

 

 

X

Lifebank USA

 

 

 

X

 

LifeCord

 

36

 

 

 

Michigan Community Blood Centers Cord Blood Bank

X

36

Per attending physician’s determination

 

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Positive Group B Strept Carrier

Active Genital Herpes

Vulvar or Perineal Condylomata

Known Fetal Structural Anomalies (e.g., Spinal Bifida)

Known Fetal Chromosome Abnormalities

Other

X

 

X

 

X

Reactive for infectious disease markers Less than 70 percent postprocessing and prefreezing viability

There is a family history of diseases, conditions, or genetic disorders that may affect the recipient

The mother has symptoms of or has been diagnosed with certain infectious diseases including West Nile virus, parasitic blood diseases, syphilis, hepatitis, and HIV/AIDS. The mother has engaged in behaviors or received medical treatments that increase the risk of contracting these diseases

X

X

X

X

X

Maternal-fetal shunt

 

 

X

 

X

Two vessel cord; temperature over 100.4°F in the infant

 

 

X

 

X

 

X

X

X

X

X

Placenta previa, placental abruption, fetal or maternal distress

X

 

X

X

X

 

 

 

X

 

X

 

 

 

 

 

X

Mother’s temperature is 100.4°F or greater

X

 

 

 

X

Placental abruption, tears, or infection, eclampsia, HELLP syndrome, stillbirth, maternal fever within 24 hours of delivery

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Bank

Multiple Gestations

Gestational Age of Less Than ______ Weeks

Chorioamnionitis (Definition at This Center)

Prolonged Rupture of Membranes (Without Chorioamnionitis)

Tear in Cord Insertion from Placenta

National Cord Blood Program of the New York Blood Center

 

 

 

 

X

New Jersey Cord Blood Bank

X

34

 

 

 

Puget Sound Blood Center and Hawaii Cord Blood Bank

X

 

 

 

 

Sibling Program Children’s Hospital Oakland Research Institute

 

32

 

 

 

St. Louis Cord Blood Bank

X

35

Placental infection, malodorous placenta

 

 

StemCyte, Inc. and Cord Blood Family Trust

X

34

The presence of foul-smelling, purulent fluid

 

X

The Elie Katz Umbilical Cord Blood Program

 

36

 

 

X

University of Colorado Cord Blood Bank

X

35

Purulent vaginal discharge with fever

 

X

Viacord

 

NOTE: no banks answered “meconium.”

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Positive Group B Strept Carrier

Active Genital Herpes

Vulvar or Perineal Condylomata

Known Fetal Structural Anomalies (e.g., Spinal Bifida)

Known Fetal Chromosome Abnormalities

Other

X

 

X

 

X

 

X

Stillborn infant

 

 

 

 

 

Known to be affected by a genetic disease

 

 

X

 

 

Maternal or infant temperature >102°F

X

 

 

 

X

Only vaginal deliveries with active genital herpes are deferred; also exclude tumor within or attached to placenta; abruptio placenta

 

 

X

 

X

Temperature >38.5°C, maternal eclampsia and/or maternal HELLP syndrome

X

X

X

X

X

Caesarean section

 

 

 

X

 

Customer choice to store or not

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-14 Screening Completed Prior to Storage

Genetic Screening

Bank

Hemoglobinopathy

ABO Group

Rh Type

Health Questionnaire

Other

Carolinas Cord Blood Bank

X

X

X

X

X

Children’s Hospital of Orange County Cord Blood Bank

X

X

X

X

 

Cryobanks International, Inc.

 

X

X

X

 

ITxM Cord Blood Services

X

X

X

X

 

JP McCarthy Cord Stem Cell Bank

X

X

X

X

 

Lifebank USA

 

 

 

X

 

LifeCord

X

X

X

X

X

Michigan Community Blood Centers Cord Blood Bank

X

X

X

X

X

National Cord Blood Program of the New York Blood Center

X

X

X

X

 

New Jersey Cord Blood Bank

X

X

X

X

 

Puget Sound Blood Center and Hawaii Cord Blood Bank

 

X

X

X

 

Sibling Program Children’s Hospital Oakland Research Institute

X

X

X

X

 

St. Louis Cord Blood Bank

X

X

X

X

 

StemCyte, Inc. and Cord Blood Family Trust

 

X

X

X

 

The Elie Katz Umbilical Cord Blood Program

 

X

X

X

 

University of Colorado Cord Blood Bank

X

X

X

X

 

Viacord

 

X

X

X

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Infectious Disease Testing

Bank

Alanine Aminotransferase (ALT)

Cholesterol

CMV IgG

CMV IgM

CMV Culture/Shell Vial

Hepatitis B Virus—HBsAg

Hepatitis B Virus—HB Core Ab

Hepatitis B Virus—NAT

Hepatitis C Virus—Ab

Hepatitis C Virus—NAT

HIV, Type 1—Ab

HIV, Type 1—P24 Ag

HIV, Type 2

Human T-cell Lymphotropic Virus, Type I

Human T-cell Lymphotropic Virus, Type II

Treponema pallidum (Syphilis)

West Nile Virus NAT

American Red Cross North Central Blood Services Cord Blood Bank

X

 

X

X

 

X

X

X

X

X

X

X

X

X

X

X

X

Carolinas Cord Blood Bank

 

X

X

X

X

X

X

 

X

X

X

X

X

X

X

Children’s Hospital of Orange County Cord Blood Bank

X

X

X

X

 

X

X

X

 

X

X

X

X

X

Cryobanks International, Inc.

 

 

X

 

 

X

 

X

 

X

X

X

X

 

ITxM Cord Blood Services

X

 

X

X

X

X

X

X

X

X

X

X

X

X

JP McCarthy Cord Stem Cell Bank

X

X

X

 

 

X

 

X

 

 

X

X

X

X

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Infectious Disease Testing (continued)

Bank

Alanine Aminotransferase (ALT)

Cholesterol

CMV IgG

CMV IgM

CMV Culture/Shell Vial

Hepatitis B Virus—HBsAg

Hepatitis B Virus—HB Core Ab

Hepatitis B Virus—NAT

Hepatitis C Virus—Ab

Hepatitis C Virus—NAT

HIV, Type 1—Ab

HIV, Type 1—P24 Ag

HIV, Type 2

Human T-cell Lymphotropic Virus, Type I

Human T-cell Lymphotropic Virus, Type II

Treponema pallidum (Syphilis)

West Nile Virus NAT

Lifebank USA

X

 

X

X

 

X

X

X

X

X

X

 

X

X

X

X

X

LifeCord

X

X

X

X

 

X

X

 

X

X

X

 

X

X

X

X

X

Michigan Community Blood Centers Cord Blood Bank

 

 

X

X

 

X

X

 

X

X

X

X

X

X

X

X

X

National Cord Blood Program of the New York Blood Center

X

 

 

X

X

X

 

 

X

X

X

 

X

X

X

X

 

New Jersey Cord Blood Bank

 

 

X

 

 

X

X

 

X

 

X

 

X

X

X

X

 

Puget Sound Blood Center and Hawaii Cord Blood Bank

 

 

X

 

 

X

 

X

X

 

X

 

X

X

X

X

X

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Sibling Program Children’s Hospital Oakland Research Institute

 

X

X

 

 

 

X

X

 

 

X

X

X

X

X

St. Louis Cord Blood Bank

 

 

 

X

 

X

X

X

X

 

X

X

X

X

X

StemCyte, Inc. and Cord Blood Family Trust

X

X

X

X

X

 

 

X

X

 

X

X

X

X

X

The Elie Katz Umbilical Cord Blood Program

 

X

X

X

X

 

X

X

X

 

X

X

X

X

X

University of Colorado Cord Blood Bank

X

X

X

X

X

 

X

 

X

X

X

X

X

X

 

Viacord

 

X

 

X

X

 

X

X

X

 

X

X

X

X

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Other Exclusions: Other Infectious Disease Testing and Travel

Bank

Other

Current FDA Travel Restrictions

American Red Cross North Central Blood Services Cord Blood Bank

 

Yes

Carolinas Cord Blood Bank

 

Yes

Children’s Hospital of Orange County Cord Blood Bank

HIV 1 and 2 NAT

Yes

Cryobanks International, Inc.

HBV Ab and CMV, total by PCR

Yes

ITxM Cord Blood Services

 

Yes

JP McCarthy Cord Stem Cell Bank

HIV and HCV NAT; HBV NAT

Yes

Lifebank USA

 

Yes

LifeCord

HIV NAT

Yes

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Any Other Recommended Travel Restrictions That Would Prevent Inclusion of the Unit?

Mother lived in any area where malaria is endemic within the past 3 years or traveled to those areas in the past 12 months. Mother spent a total time from 1980 to 1996 that adds up to 3 months or more in the United Kingdom (UK) from 1980 to 1996 or she received a blood transfusion in the UK in this time frame. Mother was born or lived in Cameroon, Central African Republic, Chad, Congo Equatorial Guinea, Gabon Niger, Nigeria, or Ivory Coast since 1977 or been the sexual partner of a person who was born in or lived in these countries in this time frame. Note: all time frames relate to date of infant’s delivery.

No

Immigrants, refugees, or citizens coming from a country in which malaria is considered endemic will be deferred for 3 years after departure from the area if they have been free from unexplained symptoms suggestive of malaria. If after their arrival in the United States they visit any region where malaria is endemic, a deferral of 3 years applies. Other donors who have traveled to a country where malaria is considered endemic will be deferred for 12 months after returning from that area, regardless of whether or not they took antimalaria prophylaxis. Also deferral if since 1980 the mother spent 5 years or more in Europe, 3 months or more in the UK from 1980 to 1986; member of military from 1980 to 1996 and spent more than 6 months in Belgium, The Netherlands, or Germany (1980 to 1990), or Spain, Portugal, Turkey, Italy, or Greece (1980 to 1996).

All exclusions applicable to whole-blood donors, e.g. malaria, vCJF, and SARS.

Mothers who have traveled to areas where malaria is endemic are deferred for 1 year after return. Immigrants from countries where malaria is endemic are deferred for 3 years after leaving the country. Persons who have lived for 5 or more years in countries where malaria is endemic are deferred for 3 years after returning to the United States. Travel to Cameroon, Central Africa Republic, Chad, Congo, Equatorial Guinea, Gabon, Niger, Nigeria, and Cote d’Ivoire since 1977 would restrict donation due to possible HIV exposure. Travel to the United Kingdom from 1980 to the present for 3 months or Europe for 6 months would restrict donation due to possible CJF.

Travel to high-risk area

  • Travel outside of United States or Canada in the past 3 years

  • Born in Africa

  • Lived in Europe since 1980

  • Spent more than 3 months since 1980 in UK

  • Member of military from 1980 to 1996

  • Spent more than 6 months between 1980 and 1996 in Belgium, The Netherlands, Germany, Spain, Portugal, Turkey, Italy, or Greece

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Other Exclusions: Other Infectious Disease Testing and Travel (continued)

Bank

Other

Current FDA Travel Restrictions

Michigan Community Blood Centers Cord Blood Bank

HIV NAT has replaced p24 Ag since fall 2003. Other genetic tests performed include for CAH, hypothyroidism, galactosemia, maple syrup urine disease, PKU, MCAD, biotinidase deficiency

Yes

New Jersey Cord Blood Bank

 

Yes

Puget Sound Blood Center and Hawaii Cord Blood Bank

HIV NAT antibody screen

Yes

Sibling Program Children’s Hospital Oakland Research Institute

HIV type 1 NAT

No

St. Louis Cord Blood Bank

CMV total Ab, HIV NAT

 

StemCyte, Inc. and Cord Blood Family Trust

HIV type 1 and type 2 NAT

Yes

The Elie Katz Umbilical Cord Blood Program

 

Yes

University of Colorado Cord Blood Bank

Future collection testing will include HIV and HCV NAT, WNV NAT

Yes

Viacord

Antibody screen HIV NAT

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Any Other Recommended Travel Restrictions That Would Prevent Inclusion of the Unit?

Malarial deferrals will result in quarantine of unit until follow-up phone call and/or other testing is performed after the deferral period. Travel areas affected by SARS would result in exclusion.

The CDC Health Information for International Travel 2003–2004 is used.

Exclusion for travel to malaria risk areas within the past 3 years (is possible to reduce the time restriction to the past 12 months). Exclusion for vCJF risk and SARS as advised by the FDA.

These are evaluated on a case-by-case basis by staff in conjunction with the medical director.

No

Defer for travel areas where malaria and SARS areas are endemic within the last 14 days, extended stay in UK (for CJF).

Collections from 1996 to 2001 utilized the then-current FDA guidelines for donor exclusion based on travel to foreign countries. However, short-term travel did not warrant exclusion.

Questions on travel history were asked and documented on health history questionnaire.

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-15 Number of Units Collected and Shipped by Year 1993–2004

Bank

Status

1993

1994

1995

1996

1997

American Red Cross North Central Blood Services Cord Blood Bank

Collected

 

 

 

 

1,350

Shipped

 

 

 

 

0

Carolinas Cord Blood Bank

Collected

 

Shipped

 

Children’s Hospital of Orange County Cord Blood Bank

Collected

0

0

0

0

0

Shipped

0

0

0

0

0

Cryobanks International, Inc. (Pr = private, Pu = public)

Collected

Pr: 0

Pr: 0

Pr: 9

Pr: 127

Pr: 143

 

Pu: 0

Pu: 0

Pu: 23

Pu: 397

Pu: 268

Shipped

Pr: 0

Pr: 0

Pr: 0

Pr: 0

Pr: 0

 

Pu: 0

Pu: 0

Pu: 0

Pu: 0

Pu: 0

ITxM Cord Blood Services

Collected

0

0

3

63

226

Shipped

0

0

0

0

0

JP McCarthy Cord Stem Cell Bank

Collected

 

Shipped

 

LifeCord

Collected

 

 

 

 

122

Shipped

 

 

 

 

0

Michigan Community Blood Centers Cord Blood Bank

Collected

 

 

 

 

 

Shipped

 

 

 

 

 

National Cord Blood Program—New York Blood Center

Collected

943

1,739

1,615

920

763

Shipped

2

16

100

214

256

New Jersey Cord Blood Bank

Collected

 

 

 

 

 

Shipped

 

 

 

 

 

Puget Sound Blood Center and Hawaii Cord Blood Bank

Collected

0

0

0

0

0

Shipped

0

0

0

0

0

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

1998

1999

2000

2001

2002

2003

2004

2,155

175

2,579

5,062

6,511

3,092

522

10

11

9

22

50

81

59

960

4,136

2,147

1,851

2,326

2,325

1,164

0

9

36

68

76

75

52

0

44

370

510

666

528

375

0

0

0

1

1

1

3

Pr: 251

Pr: 156

Pr: 126

Pr: 159

Pr: 220

Pr: 241

Pr: 75

Pu: 671

Pu: 316

Pu: 337

Pu: 1,168

Pu: 3,983

Pu: 5,256

Pu: 3,010

Pr: 0

Pr: 0

Pr: 0

Pr: 0

Pr: 0

Pr: 1

Pr: 0

Pu: 0

Pu: 0

Pu: 0

Pu: 0

Pu: 0

Pu: 491

Pu: 2

289

1,149

1,740

1,145

388

30

188

0

0

0

2

9

8

1

 

 

 

211

922

921

432

 

 

 

 

 

2

2

337

345

287

333

288

168

95

0

0

0

2

0

6

2

 

124

604

1,086

1,301

1,477

880

 

0

0

1

1

3

1

255

1,395

2,530

3,301

4,322

4,333

2,884 (as of 8/31/04)

174

174

200

115

168

214

133 (as of 8/31/04)

 

 

12

462

1,114

797

237

 

 

0

0

1

5

1

0

154

402

415

477

492

418

0

0

0

0

0

1

2

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Bank

Status

1993

1994

1995

1996

1997

Sibling Donor Cord Blood Program

Collected

 

 

 

 

4

Shipped

 

 

 

 

1

St. Louis Cord Blood Bank

Collected

 

 

 

1,487

4,708

Banked

 

 

 

695

1,544

Shipped

 

 

 

0

9

StemCyte, Inc. and Cord Blood Family Trust

Collected

0

0

0

0

0

Shipped

0

0

0

0

0

The Elie Katz Umbilical Cord Blood Program

Collected

0

0

0

4

162

Shipped

0

0

0

0

0

University of Colorado Cord Blood Bank

Collected

 

 

 

4

569

Shipped

 

Viacord

Collected

 

 

67

524

383

Shipped

 

 

 

1

2

FIGURE C-3 Units collected and shipped, by year.

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

1998

1999

2000

2001

2002

2003

2004

33

160

251

252

307

312

123

2

2

7

5

11

17

2

5,969

5,334

4,237

4,117

5,082

5,377

3,280

1,447

1,188

1,059

1,023

1,286

1,546

843

38

74

96

151

129

110

49

 

 

 

Pu: 4,198

Pu: 7,748

Pu: 1,519

Pu: 101

0

0

0

 

 

Pr: 33

Pr: 147

0

0

0

Pu: 2

Pu: 9

Pu: 30

Pu: 37

632

1,066

916

134

157

220

344

0

6

3

5

3

6

4

1,161

1,779

3,935

2,495

 

 

 

3

24

42

44

43

45

33

750

1,560

2,027

5,248

12,826

19,426

18,259 (as of 10/04)

 

1

2

3

2

1

2

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-16 Costs

 

Private

Bank

Collection

Storage

Release

American Red Cross North Central Blood Services Cord Blood Program

 

Carolinas Cord Blood Bank

 

Children’s Hospital of Orange County Cord Blood Bank

$1,700

$0

$0

ITxM Cord Blood Services

 

 

$18,000 on release

LifeCord

$0

$0

$15,500

Michigan Community Blood Centers Cord Blood Bank

 

National Cord Blood Program of the New York Blood Center

 

New Jersey Cord Blood Bank

 

Puget Sound Blood Center and Hawaii Cord Blood Bank

$655 (processing and first unit of storage $1,000)

$210/5 years

shipping charges only, in addition to any requested testing

Sibling Program Children’s Hospital Oakland Research Institute

$0

$0

$19,600

St. Louis Cord Blood Bank

 

StemCyte, Inc. and Cord Blood Family Trust

$1,450

$95/year

No cost

The Elie Katz Umbilical Cord Blood Program

$1,350 ($1,500 if paid in installment, $900 at specified hospitals)

$100/year

$0

University of Colorado Cord Blood Bank

 

Viacord

$1,800

$125/year

$0

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Public

Reimbursement

$18,000

Pending $18,500

$15,500

$15,000 per NMDP

$15,500

$25,000

$22,490—includes patient CT-negative unit CT-positive Unit DNA for transplant center CT, unit shipment in the United States

NMDP provides $15,500 for a unit when it is transplanted.

$15,000

$15,000 before 2004, $21,500 after 1/1/04

$0

$17,000

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-17 Funding of Public Banks

Bank

When

NIH

Private/Philanthropy

State Funding

American Red Cross North Central Blood Services Cord Blood Program

Currently

 

 

 

Historically

 

X

 

Carolinas Cord Blood Bank

Currently

 

 

 

 

Historically

X

X

 

Children’s Hospital of Orange County Cord Blood Bank

Currently

 

X

 

Historically

 

X

 

ITxM Cord Blood Services

Currently

 

X

 

 

Historically

 

X

 

LifeCord

Currently

 

 

 

 

Historically

 

 

 

Michigan Community Blood Centers Cord Blood Bank

Currently

 

X

 

Historically

 

X

 

National Cord Blood Program of the New York Blood Center

Currently

 

X

 

Historically

X

X

 

New Jersey Cord Blood Bank

Currently

 

 

X

 

Historically

 

X

X

Puget Sound Blood Center and Hawaii Cord Blood Bank

Currently

 

X

 

Historically

 

X

 

Sibling Program Children’s Hospital Oakland Research Institute

Currently

X

X

 

Historically

X

X

 

St. Louis Cord Blood Bank

Currently

 

X

 

 

Historically

 

X

 

StemCyte, Inc and Cord Blood Family Trust

Currently

 

X

 

Historically

 

X

 

The Elie Katz Umbilical Cord Blood Program

Currently

 

 

 

Historically

 

University of Colorado Cord Blood Bank

Currently

 

 

 

Historically

 

 

 

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Public Bank

Revenue

Other

X

 

X

Support From ARC

 

X

 

ARC

 

By participating entities, UF, Shands, LifeSouth

 

By participating entities, UF, Shands, LifeSouth

X

 

X

 

X

NYBC

X

NYBC

X

 

X

 

X

 

X

 

X

Fund raising

X

Fund raising

 

Private bank revenue

 

Private bank revenue

 

Self-supporting from reimbursement fees

 

University of Colorado Hospital

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-18 Neonatal Health Status Follow-Up

Bank

If There Is Follow-Up in Neonatal Health Status, When Is It Done?

American Red Cross North Central Blood Services Cord Blood Bank

Delivery data are assessed 24 hours or more after delivery. In addition, donors are reminded in a follow-up letter/survey mailed 60 days after delivery and in a birthday card sent at 1 year, to ask the family to report on any changes in infant’s health.

Carolinas Cord Blood Bank

Yes, 24-hour review of pediatric exam/neonatal history 6 months or more, computer system; mom’s age > 35 years and no amniocentesis follow-up unit at time of request

Children’s Hospital of Orange County Cord Blood Bank

None

Cryobanks International, Inc.

No follow-up of neonatal health status is done at present

ITxM Cord Blood Services

Yes, before release for transplantation; not always able to locate the mother

JP McCarthy Cord Stem Cell Bank

No follow-up after the baby has been discharged from the hospital

Lifebank USA

No

LifeCord

No. However, the mother is asked to call if a health problem arises; the bank receives notification of leukemia in an infant whose cord blood was donated.

Michigan Community Blood Centers Cord Blood Bank

(1) No formal follow-up. (2) Donor moms are given a card to keep in baby’s book asking for notification if child becomes seriously ill.

National Cord Blood Program of the New York Blood Center

No

New Jersey Cord Blood Bank

Follow-up from the donor is requested at 6 months and 1 year

Puget Sound Blood Center and Hawaii Cord Blood Bank

Yes, prior to transplant (when a cord blood unit has been selected for use)

Sibling Program Children’s Hospital Oakland Research Institute

Hemoglobinopathy screening is performed on the cord blood unit. Clinical status of donor is reviewed before release of the unit for transplantation

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

How Is Follow-Up Performed?

Postcard Phone Call to Mother Other

 

 

X

X

 

Review of medical record from pediatrician office

 

X

 

X

 

 

 

X

 

 

 

X

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Bank

If There Is Follow-Up in Neonatal Health Status, When Is It done?

St. Louis Cord Blood Bank

Yes, 2 weeks postdelivery and when confirmatory typing is requested on a cord blood unit

StemCyte, Inc. and Cord Blood Family Trust

The mother is asked to notify the bank of any change in the health status of the child. A letter with a SASE requesting a response regarding the health of the child is sent between 6 months and 1 year postdelivery.

The Elie Katz Umbilical Cord Blood Program

No for public units; yes for private units

University of Colorado Cord Blood Bank

No

Viacord

Not proactive, at customer request

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

How Is Follow-Up Performed?

Postcard Phone Call to Mother Other

 

X

 

 

 

X

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

TABLE C-19 How the Units Are Stored

 

Stored as

Bank

Whole Blood

Volume Reduction Only

RRC Depleted/Mononuclear Cell Product

American Red Cross North Central Blood Services Cord Blood Bank

 

 

X

Carolinas Cord Blood Bank

 

 

X

Children’s Hospital of Orange County Cord Blood Bank

 

 

X

Cryobanks International, Inc.

 

 

X

ITxM Cord Blood Services

X

 

X

JP McCarthy Cord Stem Cell Bank

 

 

X

Lifebank USA

 

 

X

LifeCord

X (<50 processed this way)

 

X

Michigan Community Blood Centers Cord Blood Bank

 

 

X

National Cord Blood Program of the New York Blood Center

 

 

X

New Jersey Cord Blood Bank

 

 

X

Puget Sound Blood Center and Hawaii Cord Blood Bank

 

 

X

Sibling Program Children’s Hospital Oakland Research Institute

 

X

 

St. Louis Cord Blood Bank

 

 

 

StemCyte, Inc. and Cord Blood Family Trust

 

 

 

The Elie Katz Umbilical Cord Blood Program

 

 

 

University of Colorado Cord Blood Bank

 

 

X

Viacell

 

 

X

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

Other

Anticoagulant Used

Cryoprotectant Used

 

CPD

DMSO/dextran

 

X

X

 

X

X

 

CPD solution

Stemsol-DMSO, 99% purity,

 

USP

USP grade

X

CPD

DMSO-dextran

 

 

X

 

X

X

 

CPD-Adenine

DMSO 10%, HES 1%, dextran40 1%

 

X

X

 

ACD-A

DMSO

 

CPD

DMSO-dextran 40, (unit nos. 668 to present) DSMO-pentastarch-plasma (unit nos 1 to 667)

Buffy coat (RBC and plasma reduced)

CPD

DMSO

Plasma depleted, non-redcell-depleted product

CPD solution

DMSO-Gentran

Red cell depleted with volume reduction

CPD

10% DMSO

 

CPD

DMSO

 

CPD

DMSO

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

ACRONYMS AND ABBREVIATIONS


AABB

American Association of Blood Banks

ACD-A

Anticoagulant Citrate Dextrose Solution, formula A

ARC

American Red Cross

ASHI

American Society for Histocompatibility and Immunogenetics


BMDW

Bone Marrow Donors Worldwide

BMT

bone marrow transplant


CAH

congenital adrenal hyperplasia

CAP

College of American Pathologists

CBB

cord blood bank

CLIA

Clinical Laboratory Improvement Amendments

CMV

cytomegalovirus

CPD

citrate-phosphate-dextrose

CRIR

Caitlin Raymond International Registry


DMSO

dimethyl sulfoxide


EBMT

European Group for Blood and Marrow Transplantation


FACT

Foundation for the Accreditation of Cellular Therapy

FDA

Food and Drug Administration


g

gram(s)


HbcAb

hepatitis B core antibody

HBV

hepatitis B virus

HCV

hepatitis C virus

HELLP

haemolysis, elevated liver enzymes, low platelets

HES

hetastarch

HIV

human immunodeficiency virus

HLA

human leukocyte antigen


IgG

immunoglobulin G

IND

investigational new drug

IRB

institutional review board

ISBT

International Society of Blood Transfusion

ISCT

International Society for Cellular Therapy

ISO

International Organization for Standardization


JACIE

Joint Accreditation Committee ISCT EBMT

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
×

JCAHO

Joint Commission for Accreditation of Healthcare Organizations


MCAD

medium-chain acyl-CoA dehydrogenase

ml

milliliter(s)


NAT

nucleic acid test

NIH

National Institutes of Health

NMDP

National Marrow Donor Program

NYBC

New York Blood Center


PCR

polymerase chain reaction

PKU

phenylketonuria


RBC

red blood cell


SARS

sudden acute respiratory syndrome

SASE

self-addressed stamped envelope

SQL

structured query language

SSP

split spectrum processing


TNC

total nucleated cell count


UCLA

University of California, Los Angeles

UF

University of Florida

USP

United States Pharmacopeia


vCJF

variant Creutzfeldt-Jakob disease


WMDA

World Marrow Donor Association

WNV

West Nile virus

Suggested Citation:"Appendix C: Survey Results." Institute of Medicine. 2005. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program. Washington, DC: The National Academies Press. doi: 10.17226/11269.
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Next: Appendix D: Potential Nonhematopoietic Uses for Stem Cells in Cord Blood »
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With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines:

  • The role of cord blood in stem cell transplantation
  • The current status of blood banks already in existence
  • The optimal structure for the cord blood program
  • The current use and utility of cord blood for stem cell transplants
  • The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.
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