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Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
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Appendix A

Workshop Agenda

Integrating Large-Scale Genomic Information into Clinical Practice

July 19, 2011

The Keck Center of the National Academies
500 Fifth Street, N.W.
Washington, DC 20001

MEETING OBJECTIVE

To highlight and identify the challenges and opportunities in integrating large-scale genomic information into clinical practice.

Workshop Assumptions:

•   Sequencing technology will advance enough to produce clinically meaningful results.

•   Whole-genome sequencing (WGS) will be cost-effective and comparable to other diagnostic tests.

 
8:30–8:35 A.M. WELCOMING REMARKS
 
 

Wylie Burke, Roundtable Chair

Professor and Chair, Department of Bioethics and Humanities, University of Washington

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
 
8:35–8:45 A.M. CHARGE TO WORKSHOP SPEAKERS AND PARTICIPANTS
 
 

Bruce Blumberg, Workshop Cochair

Institutional Director of Graduate Medical Education, Northern California Kaiser Permanente, The Permanente Medical Group

 
 

Catherine A. Wicklund, Workshop Cochair
Past President, National Society of Genetic Counselors; Director, Graduate Program in Genetic Counseling; Associate Professor, Department of Obstetrics and Gynecology, Northwestern University

 
8:45–9:15 A.M. KEYNOTE ADDRESS: THE REALIZATION OF GENOMIC MEDICINE

Leslie G. Biesecker
Chief and Senior Investigator, Genetic Disease Research Branch, National Human Genome Research Institute

 
9:15–9:45 A.M. WORKFORCE
 
  Session Moderator: Michael S. Watson, American College of Medical Genetics
 
9:15–9:45 A.M. Requisite Knowledge and Skill Sets for Large-Scale Genomic Data Utilization
 
 

Bruce R. Korf

Wayne H. and Sara Crews Finley Chair in Medical Genetics; Professor and Chair, Department of Genetics; Director, Heflin Center for Genomic Sciences, University of Alabama at Birmingham

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
 
9:45–11:50 A.M ANALYSIS
 
  Session Moderator: Debra G. Leonard, Weill Cornell Medical Center
 
9:45–10:25 A.M. Defining Actionable Novel Discoveries, Annotating Genomes, and Re-analysis—A Laboratory Perspective
 
 

Federico A. Monzon

Associate Professor of Pathology, Weill Cornell Medical College/The Methodist Hospital; Director, Research Pathology and Molecular Diagnostics Cores, The Methodist Hospital Research Institute

 
 

Madhuri Hegde

Associate Professor, Department of Human Genetics; Scientific Director, Emory Genetics Laboratory, Emory University School of Medicine

 
10:25–11:05 A.M. Defining Actionable Novel Discoveries, Annotating Genomes, and Re-analysis—A Clinical Perspective
 
 

Heidi L. Rehm

Assistant Professor of Pathology, Brigham and Women’s Hospital and Harvard Medical School; Chief Laboratory Director, Laboratory for Molecular Medicine, Partners HealthCare Center for Personalized Genetic Medicine

 
 

Michael F. Christman

President and Chief Executive Officer, Coriell Institute for Medical Research

 
11:05–11:50 A.M. Discussion with Speakers and Attendees
 
11:50 A.M. WORKING LUNCH BREAK
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
 
12:05–2:15 P.M. INTERPRETATION
 
  Session Moderator: Muin Khoury, Centers for Disease Control and Prevention
 
12:05–1:20 P.M. Interpretation Models and Context
 
  Medical Practice
 
 

Robert L. Nussbaum

Holly Smith Chair and Professor of Medicine; Chief, Division of Medical Genetics; Member, Institute of Human Genetics; Professor of Neurology, University of California, San Francisco School of Medicine

 
  Pathology
 
 

Mark S. Boguski

Associate Professor, Center for Biomedical Informatics, Harvard Medical School

 
  Bioinformatics
 
 

Nicholas J. Schork

Director of Bioinformatics and Biostatistics; Professor, Molecular and Experimental Medicine, The Scripps Translational Science Institute

 
1:20–2:15 P.M. Discussion with Speakers and Attendees
 
2:15–3:40 P.M. DELIVERY OF INFORMATION
 
  Session Moderator: W. Gregory Feero, National Human Genome Research Institute
 
2:15–2:55 P.M. Innovative Mechanisms for Delivery
 
  Integral Delivery Systems and Active Monitoring of Data
 
 

Mary V. Relling

Chair, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
 
  Granting Access to Personal Health Information
 
 

Robert H. Shelton

Founder and Chief Executive Officer, Private Access, Inc.

 
2:55–3:40 P.M. Discussion with Speakers and Attendees
 
3:40 P.M. BREAK
 
3:55–4:25 P.M ETHICAL AND LEGAL ISSUES
 
  Session Moderator: Martha Turner, American Nurses Association
 
  Ethical and Legal Implications for Integrating Large-Scale Genomic Data into Clinical Practice
 
 

Henry T. Greely

Deane F. and Kate Edelman Johnson Professor of Law; Professor, by courtesy, of Genetics; Director, Center for Law and the Biosciences, Stanford University

 
4:25–5:55 P.M PANEL DISCUSSION: ENVISIONING THE FUTURE
 
  Session Moderators: Bruce Blumberg, Northern California Kaiser Permanente
 
  Catherine A. Wicklund, National Society of Genetic Counselors
 
  Panelists:
 
 

Mark S. Boguski, Harvard Medical School

Michael F. Christman, Coriell Institute for Medical Research

Henry T. Greely, Stanford University

Madhuri Hegde, Emory University

Bruce R. Korf, University of Alabama at Birmingham

Federico A. Monzon, Weill Cornell Medical College/ The Methodist Hospital

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
 

Robert L. Nussbaum, University of California, San Francisco School of Medicine

Heidi L. Rehm, Harvard Medical School

Nicholas J. Schork, The Scripps Translational Science Institute

Robert H. Shelton, Private Access, Inc.

 
5:55–6:10 P.M. CONCLUDING REMARKS
 
 

Bruce Blumberg, Workshop Cochair Northern California Kaiser Permanente

 
 

Catherine A. Wicklund, Workshop Cochair National Society of Genetic Counselors

 
6:10 P.M. ADJOURN
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
Page 69
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
Page 70
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
Page 71
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
Page 72
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
Page 73
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2012. Integrating Large-Scale Genomic Information into Clinical Practice: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13256.
×
Page 74
Next: Appendix B: Speaker Biographical Sketches »
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The initial sequencing of the human genome, carried out by an international group of experts, took 13 years and $2.7 billion to complete. In the decade since that achievement, sequencing technology has evolved at such a rapid pace that today a consumer can have his or her entire genome sequenced by a single company in a matter of days for less than $10,000, though the addition of interpretation may extend this timeframe. Given the rapid technological advances, the potential effect on the lives of patients, and the increasing use of genomic information in clinical care, it is important to address how genomics data can be integrated into the clinical setting. Genetic tests are already used to assess the risk of breast and ovarian cancers, to diagnose recessive diseases such as cystic fibrosis, to determine drug dosages based on individual patient metabolism, and to identify therapeutic options for treating lung and breast tumors, melanoma, and leukemia.

With these issues in mind and considering the potential impact that genomics information can have on the prevention, diagnosis, and treatment of disease, the Roundtable on Translating Genomic-Based Research for Health hosted a workshop on July 19, 2011, to highlight and identify the challenges and opportunities in integrating large-scale genomic information into clinical practice.

Integrating Large-Scale Genomic Information into Clinical Practice summarizes the speaker presentations and the discussions that followed them. This report focuses on several key topics, including the analysis, interpretation, and delivery of genomic information plus workforce, ethical, and legal issues.

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