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Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
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C

Registered Attendees

Jane Acri

National Institute on Drug Abuse

Neeraj Agarwal

National Eye Institute

Alex Bailey

Food and Drug Administration

Ana Basso

Abbott

Sue Bogner

Institute for the Study of Human Error, LLC

Nathalie Breysse

Lundbeck Research USA

Lauren Briese

Physicians Committee for Responsible Medicine

Richard Brown

Dalhousie University

Neil Buckholtz

National Institute on Aging

Daniel Burch

CeNeRx BioPharma

Jiu-Chiuan Chen

University of Southern California

Theresa Chen

Food and Drug Administration

Wen Chen

National Institute on Aging

Timothy Coetzee

National MS Society

Changhai Cui

National Institutes of Health

Hirsch Davis

National Institute on Drug Abuse

Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×

Michael Didriksen

H. Lundbeck

Jamie Driscoll

National Institute of Mental Health

Subash Duggirala

Centers for Medicare & Medicaid Services

Emmeline Edwards

National Center for Complementary and Alternative Medicine

Samer Eid

Merck Research Laboratories

Danielle Evers

Office of Science and Technology Policy

Matthew Fell

Merck & Co.

Stephanie Fertig

National Institute of Neurological Disorders and Stroke

John Glowa

National Center for Complementary and Alternative Medicine

Jim Gnadt

National Institute of Neurological Disorders and Stroke

Ivana Grakalic

National Institute on Alcohol Abuse and Alcoholism

Lindsey Grandison

National Institute on Alcohol Abuse and Alcoholism

Amelie Gubitz

National Institute of Neurological Disorders and Stroke

Swapnil Gupta

Downstate Medical Center

Magali Haas

One Mind for Research

Michael Haas

BioCentury Publications Inc.

Michael Henry

St. Elizabeth’s Medical Center

David Hill

Merck & Co.

David Howland

CHDI Foundation

Carol Hubner

National Institute on Drug Abuse

William Hurst

Sanofi

Lynn Hyde

Merck Research Laboratories

Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×

Steve Hyman

The Broad Institute

Thomas Insel

National Institute of Mental Health

John Kehne

Translational Neuropharmacology Consulting

Elena Koustova

National Institutes of Health

Andrea Kudwa

Psychogenics Inc.

Audrey Kusiak

Department of Veterans Affairs

Story Landis

National Institutes of Health

Emer Leahy

Psychogenics Inc.

Wei Liang

Food and Drug Administration

Yu Lin

National Institutes of Health

Roger Little

National Institute of Mental Health

Qi-Ying Liu

National Institute on Alcohol Abuse and Alcoholism

Minda Lynch

National Institute on Drug Abuse

David McCann

National Institute on Drug Abuse

Ryan Merkley

Physicians Committee for Responsible Medicine

Eric Mohler

Abbott

Johnathan Moreno

University of Pennsylvania

Jill Morris

National Institute of Neurological Disorders and Stroke

Richard Morris

National Institutes of Health

Mahadev Murthy

National Institute on Aging

Richard Nakamura

Center for Scientific Review, National Institutes of Health

Mark Nedelman

Ekam Imaging

Antonia Noronha

National Institute on Alcohol Abuse and Alcoholism

Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×

Samia Noursi

National Institute on Drug Abuse

Kathie Olsen

ScienceWorks

Deborah Olster

National Institutes of Health

Alexander Ommaya

Department of Veterans Affairs

Javier Perez

Virginia Institute for Psychiatric and Behavioral Genetics

Suzana Petanceska

National Institute on Aging

Jonathan Pollack

National Institute on Drug Abuse

John Porter

National Institute of Neurological Disorders and Stroke

Sylvie Ramboz

Psychogenics Inc.

Lorenzo Refolo

National Institute on Aging

Soundar Regunathan

National Institute on Alcohol Abuse and Alcoholism

Robert Riddle

National Institute of Neurological Disorders and Stroke

Becky Robinson

Food and Drug Administration

Joni Rutter

National Institute on Drug Abuse

Paul Schnur

National Institute on Drug Abuse

Guy Seabrook

Janssen Pharmaceuticals

Mercedes Seraban

Food and Drug Administration

Ming Shah

National Institute on Drug Abuse

Mariela Shirley

National Institute on Alcohol Abuse and Alcoholism

David Shurtleff

National Institute on Drug Abuse

Beth-Anne Siebe

National Institute of Neurological Disorders and Stroke

Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×

Phil Skolnick

National Institute on Drug Abuse

D. Stephen Snyder

National Institute on Aging

Erica Spotts

National Institute on Aging

Michael Steinmetz

National Eye Institute

Catherine Stoney

National Institutes of Health

Amber Story

National Science Foundation

Margaret Sutherland

National Institute of Neurological Disorders and Stroke

Anna Taylor

National Institute of Neurological Disorders and Stroke

David Thomas

National Institute on Drug Abuse

Jason Uslaner

Merck & Co.

Susan Volman

National Institute on Drug Abuse

Kenneth Warren

National Institute on Alcohol Abuse and Alcoholism

David White

National Institutes of Health

Vicky Whittemore

National Institute of Neurological Disorders and Stroke

Lois Winsky

National Institute of Mental Health

Ellen Witt

National Institute on Alcohol Abuse and Alcoholism

Da-Yu Wu

National Institutes of Health

Troy Zarcone

National Institute on Alcohol Abuse and Alcoholism

Danna Zimmer

Center for Biomolecular Therapeutics

Philippe Zitoun

NOTOCORD

Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
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Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
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Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×
Page 94
Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×
Page 95
Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×
Page 96
Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×
Page 97
Suggested Citation:"Appendix C: Registered Attendees." Institute of Medicine. 2013. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13530.
×
Page 98
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Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans?

On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

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