National Academies Press: OpenBook
« Previous: Appendix A: Public Meeting Agendas
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

Appendix B


U.S. Radiation Research Programs

This appendix provides a brief summary of low-level ionizing-radiation health-effects research programs under way in the United States and under the direction of international organizations. These include several branches of the federal government with varied interests in security, defense, preparedness and response, health, and science; private organizations; academic institutions; and nonprofit organizations.

The listing is not meant to be comprehensive but rather an overview of major efforts related to the committee’s task. Websites for further information are listed in Table B-1 at the end of this appendix.

Myriad research, educational, and administrative agencies and organizations have an interest in low-level and low linear energy transfer (LET) radiation. Some are focused on national defense and the risks of nuclear weapons and the resulting public health response, others are dedicated to workers and environments affected by nuclear power generation, and still others are concerned with cosmic radiation. The following section describes U.S. federal programs and initiatives that investigate and plan responses to the effects of low-level radiation exposure. Some of these programs have broad missions, of which radiation and low-level issues are just one piece.

DEPARTMENT OF DEFENSE

The Department of Defense (DoD) sponsors research on the health effects of ionizing radiation in line with its mission to protect and preserve military-force readiness and the health of military personnel. In addition to the other work performed by the Armed Forces Radiobiology Research

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

Institute (AFRRI), it is involved in the efforts described in the following sections.

Defense Advanced Research Projects Agency

Established in 1958, the Defense Advanced Research Projects Agency (DARPA) is dedicated to the advancement of science and technology for the U.S. military and bridging the gap between scientific discovery and military applications (DARPA, 2009). By sponsoring and conducting investigations with multidisciplinary approaches and finite duration, DARPA seeks to advance current knowledge and create innovative solutions through applied research. The research it conducts and sponsors is intended to be cutting edge, high risk, and high payoff. Its scientific areas include biology, medicine, computer science, chemistry, physics, engineering, mathematics, material sciences, and social sciences.

The Agency has a continuing interest in the health effects of radiation and, as noted in Chapter 5, has undertaken three initiatives in the last 10 years related to ionizing radiation health effects. The first of these was a 2005 effort to develop technologies to minimize the warfighter’s vulnerability to radiation exposures via vaccines and novel antidotes (DARPA, 2005). The second effort was the Radiation Bio-Dosimetry (RaBiD) program, which ran from 2008 through 2011 and whose purpose was to develop “non- or minimally invasive, portable and low-cost radiation biodosimeters, as well as novel radiation mitigation technologies that can be administered 12 or more hours after exposure and provide better than 90-percent survivability to humans” (DARPA, 2012). A 2007 solicitation indicates that AFRRI was responsible for testing biodosimeter prototypes developed under the effort (DARPA, 2007). Then, in February 2013, the Agency issued a request for information for “ideas, methodologies, and approaches … [that] may be used to support a potential new DARPA program to enable novel therapies for mitigating the effects of ionizing-radiation exposure in military or civilian personnel in the aftermath of a large-scale release of nuclear material that may result from either a natural disaster or a deliberate attack” (DARPA, 2013).

Defense Threat Reduction Agency

The Defense Threat Reduction Agency (DTRA) was created to ensure the safety of the United States and its allies by working to reduce, eliminate, and counter threats posed by weapons of mass destruction (WMDs), including chemical, biological, radiological, nuclear, and high-yield explosive (CBRNE) WMDs. DTRA’s efforts include basic and applied research in addition to operational support and think tanks (DTRA, undated).

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

DTRA also acts as DoD’s executive agent for the Nuclear Test Personnel Review (NTPR) Program. This program provides participation and radiation-dose information to veterans who participated in U.S. atmospheric nuclear tests, served with the American occupation forces of Hiroshima and Nagasaki, Japan, or were prisoners of war in these areas at the conclusion of World War II (DTRA, 2009).

More recently, DTRA has conducted assessments and issued reports on radiation exposure in U.S. Coast Guard veterans (DTRA, 2011) and many pertaining to radiation exposure among U.S. forces associated with the Operation Tomodachi response to the Fukushima Daiichi nuclear reactor accident in 2011 (NCRP, 2012).

DEPARTMENT OF ENERGY

The Department of Energy (DOE) participates in several initiatives supporting research and education concerning low-level and low-LET radiation through diverse programs and laboratories. Those that are most pertinent to the committee’s task are discussed below.

Low Dose Radiation Research Program

DOE’s Office of Science’s Office of Biological and Environmental Research established the Low Dose Radiation Research Program in 1999 (DOE, 2012). The primary aims of the program were to support experimental research and to generate data that could be adapted by regulatory agencies such as the Environmental Protection Agency (EPA) and the U.S. Nuclear Regulatory Commission to set future radiation standards and develop national policy for the protection of the public and the workforce during environmental cleanup, nuclear waste storage, and use of nuclear power. Today, radiation-protection standards and operating policies, such as “as low as reasonably achievable,” are derived from the conservative assumption of the linear no-threshold (LNT) model. Because most human exposures to radiation are of low dose or low dose rate, the program concentrates on studies of low-LET exposures delivered at low total doses and low dose rates.

The program was intended to take advantage of the advances in molecular biology and instrumentation that were not available during the previous 50 years of radiation-biology research (Brooks, 2012). As such, it has paid particular attention to experimental research on bystander effects, adaptive responses, genomic instability, and mathematical and risk modeling that incorporates knowledge from low-level experimental research into mechanism-based models of tissue function.

As of 2013, about 40 percent of the program’s funds supported research projects at academic institutions, and the remaining 60 percent supported

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

research at three DOE-affiliated national laboratories: Lawrence Berkeley National Laboratory (LBNL), Oak Ridge National Laboratory (ORNL), and Pacific Northwest National Laboratory (PNNL) (DOE, 2013a). However, the (March 2014) DOE fiscal year (FY) 2015 congressional budget request puts forward a substantial decrease in funding levels, from ~$6.2M for FY 2013 to a proposed $2.4M for all radiobiology research in FY 2015 (DOE, 2014).

DOE is also a cosponsor of the Million U.S. Worker Study, which is examining health outcomes in a number of cohorts occupationally exposed to low-level radiation, including “uranium and plutonium workers at DOE sites, nuclear weapons test participants, nuclear power plant workers, and industrial radiographers, radiologists, and other medical practitioners” (ORAU, 2013).

Low Energy Nuclear Physics Research

The Low-Energy subprogram studies the nuclear structure, astrophysics, and fundamental symmetry and neutrinos at two Nuclear Physics Program user facilities. The personnel at the Argonne Tandem LINAC Accelerator System (ATLAS) at Argonne National Laboratory study nuclear properties under extreme conditions and reactions of interest using high-quality beams of all the stable elements up to uranium and selected beams of short-lived nuclei. The Holifield Radioactive Ion Beam Facility at ORNL staff studies exotic nuclei that do not normally exist in nature with beams of short-lived radioactive nuclei. The future Facility for Rare Isotope Beams will have next-generation equipment to advance the understanding of rare nuclear isotopes and the evolution of the cosmos. The subprogram supports four university Centers of Excellence, three with unique low energy–accelerator facilities and one with infrastructural capabilities for developing advanced instrumentation. The subprogram also partners with the National Reconnaissance Office and the U.S. Air Force to support limited operations of the 88-inch cyclotron at LBNL for a small in-house research program and to meet national security needs. Additionally, nuclear physicists at the Spallation Neutron Source at ORNL study the properties of neutrinos and their masses (DOE, 2013b).

Workforce Development for Teachers and Scientists (WDTS)

DOE supports efforts to provide opportunities for science, technology, engineering, and mathematics (STEM) workforce development, known as Workforce Development for Teachers and Scientists (DOE, 2013c). This effort offers access to leading scientists; world-class scientific user facilities and instrumentation; and large-scale, multidisciplinary research programs un-

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

available in universities or industry. The laboratories also provide opportunities for science, engineering, and technology training and education for more than 250,000 K–12 students, 22,000 K–12 educators, 4,000 undergraduate interns, 3,000 graduate students, and 1,600 postdoctoral researchers annually. Although these efforts are not focused on ionizing-radiation health research, they do include opportunities for those interested in the field.

National Nuclear Security Administration

The National Nuclear Security Administration was established by Congress in 2000 to support the management and security of the nation’s nuclear weapons, nuclear nonproliferation, and naval reactor programs. It is a separate agency in DOE that focuses on defense, nuclear nonproliferation, naval nuclear energy, nuclear security, and counterterrorism and counterproliferation (DOE, undated).

NATIONAL AERONAUTICS AND SPACE ADMINISTRATION

To continue to its mission of space exploration, the National Aeronautics and Space Administration (NASA) must understand and prevent risk to crew members sent into space, including the risks posed by solar and cosmic radiation. Without the protection of Earth’s atmosphere, space crew may be at increased risk of acute radiation sickness, cancer, and other chronic diseases associated with radiation exposure. High-energy solar radiation from the sun, sun flare, and cosmic radiation originating in deep space pose unique challenges.

Space Radiation Health Program

NASA’s Space Radiation Health Program, Office of Biological and Physical Research, and DOE jointly fund research to help understand the radiation risks associated with travel in space (NASA, 2014). Because the radiation environment in space differs from that on Earth, NASA is especially interested in the health risks associated with human exposure to low levels of the high-energy ionizing radiation (alpha particles, protons, and high-energy heavy ions) that comprise the solar wind and cosmic rays and in the resulting health risks to crew members. NASA’s research focuses on characterizing the risks resulting from space radiation for cancers, acute or late central nervous system effects, degenerative tissue effects, and acute risks. Its research also seeks to develop radiation countermeasures to effectively prevent and treat potential cosmic radiation damage.

Research is carried out at several research facilities, including the Johnson Space Center, the Langley Research Center, the Ames Research

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

Center, and the Brookhaven National Laboratory (BNL). Efforts are focused on learning more about the radiation environments that crew members will encounter during long-duration missions to the moon and Mars.

National Space Biomedical Research Institute

The National Space Biomedical Research Institute (NSBRI), founded in 1997 by NASA, is a nonprofit science institute dedicated to ensuring safe and productive spaceflight. It comprises 12 institutions that study the health risks related to long-duration spaceflight and develop methods to reduce those risks. The NSBRI supports the investigation of several areas of medical science, one of which is radiation effects. The Radiation Effects Team supports research on health risks and mitigation strategies specifically related to cosmic radiation, with an emphasis on acute effects and on dosimetery to monitor and provide advance warning of risks inside the spacecraft and out. The NSBRI Center of Acute Radiation Research (CARR), headquartered at the University of Pennsylvania through 2013, is a central component of the Radiation Effects Team that has multiple projects assessing the effects of exposure from solar events, defining associated health risks, and developing safe and effective methods to prevent and treat acute radiation–syndrome symptoms. The CARR includes researchers from the University of Illinois, the Massachusetts Institute of Technology, and AFRRI (NSBRI, undated a, undated b).

NSBRI also includes an educational component with a robust teaching, training, and public outreach program (NSRBI, 2012).

Human Research Program

NASA’s Human Research Program collects data on radiation exposure from returning crew members. Findings are used to inform guidelines for exposure and safety procedures. The Human Research Program comprises scientists and engineers dedicated to research on radiation exposure during space flights and development of solutions and technologies to reduce health risks. Most research focuses on physiology, environment, and technology study areas. Future research will explore the unique challenges and risks posed by extended space missions (NASA, 2009).

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Several areas within the Department of Health and Human Services (HHS) are involved in radiation-research and public health–preparedness activities. Its institutes, centers, and agencies pursue a range of endeavors,

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

including research, training, emergency planning and response, outreach, policy support, and regulations related to radiation exposure.

National Cancer Institute

The National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch (REB) conducts a number of national and international studies on populations exposed to radiation for medical, environmental, and occupational reasons. Among its international collaborations are efforts with the Research Center for Radiation Medicine in Ukraine to conduct studies of the Chernobyl-affected population, the Southern Urals Biophysics Institute for research on workers at the Mayak nuclear facility, and the University of Newcastle to evaluate the relationship between radiation exposure from computed tomography (CT) scans conducted during childhood and adolescence. REB additionally supports radiation dosimetry work to support the epidemiologic studies.

Epidemiologic study activities at REB include

  • Efforts to identify and quantify the risk of cancer associated with ionizing and nonionizing radiation, especially at low-dose levels;
  • Characterization of the risk of radiation-induced cancer in terms of tissues at risk, dose response, biological effectiveness, dose rate, time since exposure, sex, age at exposure and at observation, and possible modifying influences of other environmental and host factors;
  • Methods for radiation-dose reconstruction for environmental, occupational, and medical exposures;
  • Applications of dosimetry in studies of countermeasures against radiological and nuclear threats;
  • Examination of biologically based models of radiation-induced carcinogenesis;
  • Case-control and cohort studies of cancer risk in populations exposed to occupational, environmental, or medical diagnostic or therapeutic radiation;
  • Population-based studies to examine biomarkers of radiation exposure; and
  • Individual variation in radiogenic risk associated with a wide range of demographic, racial or ethnic, geographic, physiologic, hormonal and immune function, and genetic factors.

REB also advises and collaborates with other agencies and individuals involved in radiation research and regulatory activities (NCI, undated a).

The Radiation Research Program (RRP) of the Division of Cancer

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

Treatment and Diagnosis at NCI supports basic, translational, and clinical research in radiotherapy and radiation biology. The RRP is divided into three branches: Radiotherapy Development, Clinical Radiation Oncology, and Molecular Radiation Therapeutics. In its effort to stimulate radiotherapy and radiation-biology research, the RRP serves as an advisor to researchers, an evaluator of conducted research and future research priorities, and a liaison to the Medical Countermeasures against Radiological and Nuclear Threats Initiative of NCI, the National Institute of Allergy and Infectious Diseases (NIAID), and the Office of the Assistant Secretary for Preparedness and Response. RRP staff also review grant proposals and contracts submitted to DoD and the Biomedical Advanced Research and Development Authority (BARDA) and consult on radiation issues with program staff in NIAID (NCI, undated b).

The Developmental Therapeutic Program (DTP), which was created by Congress in 1955, serves as the focal point for research on chemotherapeutic agents within NCI. DTP facilitates the work of academic and private sector investigators and has helped to bring a number of widely used agents to market.

National Institute of Allergy and Infectious Diseases

NIAID’s research focus on immunology, which includes research on adult bone marrow stem cells, transplantation, and immune reconstitution, is relevant to ionizing-radiation research because ionizing radiation can cause immunosuppression after damage to the hematopoietic cells. Its Radiation and Nuclear Countermeasures Program is a focal point for such work.

The NIH Strategic Plan and Research Agenda for Medical Countermeasures against Radiological and Nuclear Threats is the result of an HHS request to NIAID to develop and guide a research program for the development of effective medical countermeasures against possible terrorist-attack scenarios involving radioactive materials (NIAID, 2005). This initiative was the first federal mission to develop countermeasures for civilian populations. Funding is provided through a special congressional appropriation to HHS’s Office of Public Health Emergency Preparedness.

In 2005, NIAID established eight cooperative Centers for Medical Countermeasures against Radiation (CMCR). The CMCR is intended to develop radioprotectors, mitigators, and therapeutic agents to facilitate effective medical response against radiological and nuclear threats. Additionally, the CMCR supports the development of biomarkers and biodosimetry techniques and devices for rapid triage and treatment of individuals exposed to radiation after a radiological event. Another aim of the CMCR

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

network is to provide new or expanded educational resources to improve expertise in radiation biology.

To meet its goals, NIAID works in partnership with the Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and BARDA to develop, license, procure, and deploy effective medical countermeasures against radiation threats (NIAID, 2013).

Office of the Assistant Secretary for Preparedness and Response

The Biomedical Advanced Research and Development Authority is responsible for the development and procurement of countermeasures to prepare the nation to respond to and recover from public health emergencies. BARDA is involved in all stages of product development from development and manufacture, safety and regulatory affairs, to supply issues, including stockpiling, storage, and transportation. Within BARDA, the Division of Chemical, Biological, Radiological and Nuclear (CBRN) Medical Countermeasures (MCMs) is responsible for CBRN MCMs required by the HHS to mitigate the adverse health effects arising from public health emergencies, including anthrax, smallpox, various chemical threats, and radiation (BARDA, 2013).

FOOD AND DRUG ADMINISTRATION

Radiological Health Program

The mission of FDA’s Radiological Health Program is to protect the public from hazardous or unnecessary radiation exposure from radiation-emitting electronic products. The program is carried out as a part of FDA’s Center for Devices and Radiological Health (CDRH). The CDRH aims to support the mission of the radiological health program by supporting

  • Awareness of new and existing radiation-emitting products, their manner of use, and their manufacturers;
  • Study of the biological effects of radiation-emitting products and their potential risks to health;
  • Assessment of radiation-emission levels from products in various applications;
  • Direction and guidance to the general public and users of radiation-emitting products to minimize unnecessary radiation exposure; and
  • Product manufacturer compliance with all applicable requirements, pursuing regulatory and enforcement actions to address public health problems.
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

CDRH is able to regulate radiation-emitting electronic products used for both medical and nonmedical applications under authority provided by the Electronic Product Radiation Control provisions and the Medical Device Amendments of 1976 of the Federal Food, Drug, and Cosmetic Act. It also regulates facilities performing mammography under the authority of the Mammography Quality Standards Act. Further, CDRH supports FDA’s radiation emergency–response activities to protect the public and communicates with stakeholders from governmental, professional, academic, manufacturing, and consumer-advocacy groups (FDA, 2012).

Center for Drug Evaluation and Research

The Center for Drug Evaluation and Research (CDER) is responsible for ensuring the safety, effectiveness, and availability of prescription and over-the-counter drugs, including countermeasures for use in a public health emergency. Currently, CDER lists three drugs as safe and effective for the prevention and treatment of radiation effects: potassium iodide, calcium- and zinc-DTPA, and Prussian blue (FDA, 2011).

Office of Counterterrorism and Emerging Threats

The Office of Counterterrorism and Emerging Threats (OCET) coordinates the various offices and departments within the FDA to oversee the development, availability, and safety of emergency medical countermeasures and the prevention of contamination, corruption, or disruption of medical supplies in a terrorist attack. OCET also administers the Medical Countermeasures initiative (MCMi) as an effort to coordinate intraagency and interagency communication and emergency-use authorizations, giving the FDA Commissioner the authority to allow the use of unapproved medical products in an emergency (FDA, 2013).

CENTERS FOR DISEASE CONTROL AND PREVENTION

Agency for Toxic Substances and Disease Registry

The Agency for Toxic Substances and Disease Registry (ATSDR) is dedicated to protecting public health by using the best science available to provide accurate health information and prevent harm from exposure to toxic substances, including radioactive substances and ionizing radiation. ATSDR publishes Toxicological Profiles (ToxProfiles) that summarize the available information about a substance and describe its health effects. ATSDR also assesses industrial sites to determine health risks to workers,

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

cleanup personnel, and surrounding communities. Many of the hazardous waste sites are DOE or military facilities related to nuclear-weapons development, research, and testing (ATSDR, 2013; CDC, 2010).

National Institute of Occupational Safety and Health

The National Institute for Occupational Safety and Health (NIOSH) is the lead federal agency for research on worker injury and illness. As part of its responsibility, it conducted studies of several populations with exposure to low levels of ionizing radiation under the aegis of its Occupational Energy Research Program. This program, which is no longer active, developed exposure characterization models for and examined health outcomes in several cohorts, including those associated with the Portsmouth Naval Shipyard, Fernald Feed Materials Production Center, Hanford Site, Los Alamos National Laboratory, Mallinckrodt Uranium Works, Mound Site, Oak Ridge Facilities (K-25, X-10, Y-12), Paducah Gaseous Diffusion Plant, Portsmouth Gaseous Diffusion Plant, Rocky Flats, and Savannah River National Laboratory (NIOSH, 2011).

The Radiation Dose Reconstruction Program area of the NIOSH Division of Compensation Analysis and Support operates in support of the Energy Employees Occupational Illness Compensation Program Act, which is administered by the Department of Labor (DOL, undated). NIOSH performs radiation-dose reconstruction for DOE workers and contractors exposed to radiation in support of the nuclear weapons program for the purposes of compensation. Oversight of the dose reconstruction methods and guidelines and the classification of special exposure cohorts (groups of radiation-exposed workers) is provided by the presidentially appointed Advisory Board on Radiation and Worker Health (NIOSH, 2014).

Because few studies have been conducted to characterize the cosmic-radiation exposure and associated health effects in U.S. flight personnel working in commercial aircraft, NIOSH established the Flight Crew Research Program in collaboration with the Federal Aviation Administration (FAA), NCI, HHS Office of Women’s Health, and DoD Women’s Health Research Program. Studies include a variety of outcomes, including menstrual function, pregnancy outcomes, infertility, cancer, stress, respiratory symptoms, and mortality (CDC, 2012).

FEDERAL AVIATION ADMINISTRATION

Radiobiology Research Team

The Radiobiology Research Team of the FAA performs research on the effects of ionizing and nonionizing radiation on living systems, identi-

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

fies radiation hazards in the aviation environment, and studies methods of protection from such hazards. As part of the FAA’s aerospace medical research program, investigators focus on bioaeronautical aspects of safety and security, including forensic toxicology, functional genomics, biochemistry, radiobiology, environmental physiology, and bioinformatics, at the Civil Aerospace Medical Institute (CAMI).

The CARI-6 computer program, developed at CAMI, calculates the effective dose of cosmic radiation received by an individual (based on an anthropomorphic phantom) on an aircraft flying the shortest route (i.e., a geodesic) between any two airports in the world. The program takes into account changes in altitude and geographic location during the course of a flight, as derived from the flight profile entered by the user (FAA, 2013).

ENVIRONMENTAL PROTECTION AGENCY

Because radiation is ubiquitous in the environment at low levels and is a frequent contaminant resulting from industrial activities, EPA has many duties pertaining to it.

Radiation Protection Programs

Within EPA several offices are tasked with radiation protection activities. The Office of Air and Radiation is primarily responsible for the Radiation Protection Program, but other functions are carried out in other areas. Those areas include waste management; emergency response; air and water; source reduction and management; naturally occurring radiation; cleanup and multi-agency programs; risk assessment and federal guidance; and environmental monitoring and data. Through these programs, EPA has responsibilities to assess and monitor human health risks resulting from environmental radiation exposures; to set standards and regulations for radioactive emissions in air, water, and soil; to provide guidance for cleanup of contaminated sites; to communicate with the public about radiation risks such as radon; and to coordinate with other federal agencies for emergency response and homeland security (EPA, 2012).

DEPARTMENT OF VETERANS AFFAIRS

The interest of the Department of Veterans Affairs (VA) in radiation health effects is primarily focused on providing health care and benefits and disability compensation to veterans. Veterans who were exposed to radiation during their military career may be eligible for disability and health care benefits through the VA for specific cancers and chronic diseases. The VA offers Ionizing Radiation Registry health exams to all eligible veterans

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

who were potentially exposed to ionizing radiation during their military service, including atmospheric nuclear tests, occupation of Hiroshima or Nagasaki, status as a prisoner of war in Japan during World War II, nasopharyngeal radium-irradiation treatments, service at a DOE gaseous-diffusion plant, or proximity to an underground nuclear test site. It also produces educational materials for veterans, their families, and physicians on these topics (VA, 2013).

Public Health Epidemiology Program

The VA’s Epidemiology Program conducts the Cancer Mortality among Military Participants at U.S. Nuclear Weapons Tests study. The study aims to identify cancer risks in Cold War–era veterans who participated in atmospheric nuclear weapons tests (1946–1958) (VA, 2012).

DEPARTMENT OF STATE

The Department of State’s concern for radiation-related exposures and associated health effects stems from its mission to protect and advance the freedom of the American people and its international community. This includes protection from and response to nuclear threats, specifically the proliferation of WMDs and related materials, technologies, and expertise that challenge U.S. national security. The Department of State is home to two radiation-related offices that fulfill this role. It does not conduct or foster health effects–related research, except in the policy arena.

Bureau of International Security and Nonproliferation

The Bureau of International Security and Nonproliferation (ISN) manages a broad range of U.S. nonproliferation policies, programs, agreements, and initiatives to prevent the spread of WMDs (nuclear, biological, chemical, or radiological) and delivery systems. The ISN bureau combats the threat posed by the proliferation of WMDs, and terrorist efforts to obtain them, through bilateral and multilateral diplomacy. This is one of the highest priorities of the Department of State.

Bureau of Counterterrorism

The Bureau of Counterterrorism includes several programs and initiatives to prevent and respond to terrorism (including WMDs) both domestically and internationally; these efforts include radiologic events at both levels. The Counterterrorism Preparedness Program within the Bureau of

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

Counterterrorism focuses on strengthening the nation’s capacity to prevent, protect from, respond to, and recover from attacks involving WMDs.

U.S. NUCLEAR REGULATORY COMMISSION

The U.S. Nuclear Regulatory Commission (U.S. NRC) was created by the 1974 Energy Reorganization Act to address several broad public health and safety issues in the nuclear power industry. The commission is responsible for nuclear-reactor oversight, including regulations and licensing. The use of nuclear materials for power generation imposes the risk of radiation exposure on workers and the general public, and regulatory requirements are thus developed to protect public health.

U.S. NRC’s research efforts are led by the Office of Nuclear Regulatory Research, which interfaces with all areas of the program and other government agencies (such as DOE), universities, and international partners to coordinate activities. The office recommends and conducts research pertaining to nuclear reactors, materials, and radioactive waste to improve knowledge in areas of uncertainty to inform regulatory decisions (U.S. NRC, 2013a, 2014). One such activity is an analysis of cancer risks in populations residing near nuclear power reactors that is currently being conducted by the National Research Council (U.S. NRC, 2013b).

U.S. NRC’s low-level radiation interests include the management and disposal of low-level waste and the risk assessment and mitigation of releases from nuclear power facilities (U.S. NRC, 2013c).

SELECTED PRIVATE AND ACADEMIC LOW-LEVEL–RADIATION RESEARCH INITIATIVES

Lovelace Respiratory Research Institute

Research at the Lovelace Respiratory Research Institute includes elucidating the biological bases for radiation-adaptive responses in the lung and for suppressing lung cancer and using the knowledge gained to produce an improved systems biology–based risk model for lung cancer induction by low-dose, low-LET radiation. Lovelace aims to encourage development of new low-level radiation risk–benefit assessment methods for use in medicine and health, such as low-dose diagnostic radiation for cancer therapy and low-dose, low-LET radiation to prevent lung cancer in high-risk groups (heavy smokers, for example) (LRRI, 2010, 2014).

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

Center for High-Throughput Minimally Invasive Radiation Biodosimetry

The Center for High-Throughput Minimally Invasive Radiation Biodosimetry is a consortium of research institutions composed of Georgetown University, Lovelace Respiratory Research Institute, New York University School of Medicine, Translational Genomics Research Institute, and University of Bern, led by Columbia University (Columbia University, 2012). The center, funded by NIAID, applies modern radiation-biological techniques to detect biological changes as a measure of radiation dose. In addition to conducting and funding research and pilot projects, the center supports several training courses and workshops on biodosimetry.

U.S. Transuranium and Uranium Registry

The U.S. Transuranium and Uranium Registry (USTUR) research program is focused on the study of biokinetics, dosimetry, and biological effects of measurable and documented exposures to uranium, plutonium, americium, and thorium in humans. Data are gathered from generous partial and whole-body donations from exposed government workers who may have participated in the development and testing of nuclear weapons during the Cold War, been employed at uranium milling and mining operations, or worked at one of many DOE sites such as Hanford or Fernald. The registry includes medical, dosimetry, personal, occupational, and cause-of-death data from 335 donations, with a total of 875 individuals in the registry as of March 31, 2012. USTUR was begun in 1968 and is currently operated by the University of Washington and funded by the DOE Office of Health, Safety, and Security (USTUR, 2007).

SELECTED NONPROFIT ORGANIZATIONS

National Council on Radiation Protection and Measurements

The National Council on Radiation Protection and Measurements (NCRP) is a nonprofit organization chartered by the U.S. Congress to facilitate the dissemination of information on radiation protection and measurements significant to the public interest (NCRP, 2014). The council seeks to facilitate and encourage collaboration between other organizations involved in the scientific and related aspects of radiation protection and measurement. This bridge creates a platform for conversation between national and international programs involved in similar subjects to discuss and focus on recommendations. NCRP publications serve as guides to research in the field of radiation. As noted in Chapter 3, the organization has an interest in ensuring a robust radiation health–research workforce

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

and has been undertaking efforts to determine whether the future supply of investigators will meet the demand (Pryor, 2013).

Electric Power Research Institute

The Electric Power Research Institute is an independent nonprofit organization dedicated to research, development, and demonstration related to power generation, delivery, and public use. Its research spans all aspects of power and is focused on both long- and short-term solutions. It includes a low-dose radiation research program that seeks to gain new knowledge about the biological effects and risks of low doses of radiation associated with the normal operation of nuclear power plants to ensure that workers and the public are adequately protected (Dauer et al., 2010; EPRI, 2009, 2011, 2014).

Radiation Countermeasures Center of Research Excellence

The Radiation Countermeasures Center of Research Excellence, or RadCCORE, is dedicated to supporting basic, translational, and applied research to further develop medical countermeasures against nuclear attacks. This multidisciplinary-research center seeks to develop and move countermeasure candidates through the regulatory process and to add them to the national stockpile. Specific program areas are dedicated to biodosimetry, drug development, therapies to treat acute radiation syndrome, and methods to modulate immune response to radiation exposure. RadCCORE also seeks to expand education resources and improve expertise in radiobiology by offering workshops and seminars and by funding graduate fellowships. The members of RadCCORE come from five universities (Duke University; University of Arkansas for Medical Sciences; University of Maryland, Baltimore; University of North Carolina; and Wake Forest University) as well as from national laboratories and private enterprises (RadCCORE, 2012).

REFERENCES

ATSDR (Agency for Toxic Substances and Disease Registry). 2013. About ATSDR. http://www.atsdr.cdc.gov/about/index.html (accessed January 2, 2014).

BARDA (Biomedical Advanced Research and Development Authority). 2013. BARDA unveils path forward in the BARDA Strategic Plan 2011-2016. http://www.phe.gov/about/barda/Pages/2011barda-stratplan.aspx (accessed January 2, 2014).

Brooks, A. L. 2012. A history of the United States Department of Energy (DOE) Low Dose Radiation Research Program 1998-2008 (Review Draft). http://lowdose.energy.gov/pdf/albRoughDraft/doeHistoryComplete09262012.pdf (accessed January 2, 2014).

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

CDC (Centers for Disease Control and Prevention). 2010. Dose reconstruction and the Cold War. http://www.cdc.gov/nceh/radiation/public_health_research.htm (accessed January 2, 2014).

CDC. 2012. The Flight Crew Research Program. http://www.cdc.gov/niosh/topics/flightcrew (accessed January 2, 2014).

Columbia University. 2012. Center for High-Throughput Minimally-Invasive Radiation Biodosimetry. http://cmcr.columbia.edu (accessed January 2, 2014).

DARPA (Defense Advanced Research Projects Agency). 2005. Bridging the gap. Powered by ideas. http://www.dtic.mil/cgi-bin/GetTRDoc?Location=U2&doc=GetTRDoc.pdf&AD=ADA433949 (accessed December 30, 2013).

DARPA. 2007. Proposer information pamphlet for BAA 07-29 for the Defense Advanced Research Projects Agency (DARPA) radiation biodosimetry (RaBiD). https://www.fbo.gov/utils/view?id=96890b83dc24a7efa62f1c2b58d148ec (accessed April 14, 2014).

DARPA. 2009. Bridging the gap. Powered by ideas. Presented at the European Command and African Command Science and Technology Conference held in Stuttgart, Germany, on 8-12 Jun 2009. http://www.dtic.mil/dtic/tr/fulltext/u2/a510795.pdf (accessed January 2, 2014).

DARPA. 2012. DARPA news: Researchers successfully treat previously lethal doses of radiation. January 12, 2012. http://www.darpa.mil/NewsEvents/Releases/2012/01/04.aspx (accessed April 14, 2014).

DARPA. 2013. Reducing ionizing radiation risk. Request for information. RFI DARPA-SN-13-24. https://www.fbo.gov/index?s=opportunity&mode=form&id=dfd9728586164c8cdd7a1d6391d692dd&tab=core&_cview=0 (accessed December 30, 2013).

Dauer, L. T., A. L. Brooks, D. G. Hoel, W. F. Morgan, D. Stram, and P. Tran. 2010. Review and evaluation of updated research on the health effects associated with low-dose ionising radiation. Radiation Protection Dosimetry 140(2):103-136.

DOE (U.S. Department of Energy). 2012. Low dose radiation research program. http://lowdose.energy.gov (accessed January 2, 2014).

DOE. 2013a. Radiobiology: Low dose radiation research. Biological systems science division (BSSD). http://science.energy.gov/ber/research/bssd/low-dose-radiation (accessed January 2, 2014).

DOE. 2013b. Nuclear physics: Research. Office of Science. http://science.energy.gov/np/research (accessed January 2, 2014).

DOE. 2013c. Workforce Development for Teachers and Scientists (WDTS). Office of Science. http://science.energy.gov/wdts (accessed January 2, 2014).

DOE. 2014. Department of Energy FY 2015 Congressional budget request. Volume 4. Science. Advanced research projects agency—Energy. March 2014. Washington, DC: DOE, Office of Chief Financial Officer. http://www.energy.gov/sites/prod/files/2014/03/f12/Volume_4.pdf (accessed April 3, 2014).

DOE. Undated. About us. National Nuclear Security Administration. http://nnsa.energy.gov/aboutus (accessed January 2, 2014).

DOL (U.S. Department of Labor). Undated. About EEOICP. http://www.dol.gov/owcp/energy/index.htm (accessed January 2, 2014).

DTRA (Defense Threat Reduction Agency). 2009. Radiation exposure in the U.S. atmospheric nuclear weapons testing—Fact sheet. October 2009. http://www.dtra.mil/documents/ntpr/factsheets/Radiation_Exposure.pdf (accessed January 2, 2014).

DTRA. 2011. Personnel radiation exposure associated with X-rays emanating from U.S. Coast Guard LORAN high voltage vacuum tube transmitter units. Technical report. DTRA-TR-10-26. July 2011. http://www.dtra.mil/documents/pdfs/DTRA-TR-10-26%20-%20USCG%20LORAN%20Transmitter%20X-Ray%20Exposure.pdf (accessed January 2, 2014)

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

DTRA. Undated. About DTRA/SCC-WMD. www.dtra.mil/About.aspx (accessed January 2, 2014).

EPA (Environmental Protection Agency). 2012. Radiation protection: Basic information. www.epa.gov/radiation/basic/index.html (accessed January 2, 2014).

EPRI (Electrical Power Research Institute). 2009. Program on technology innovation: Evaluation of updated research on the health effects and risks associated with low-dose ionizing radiation. Final Report, 1019227. Palo Alto, CA: EPRI, Inc.

EPRI. 2011. Strategic program: Low-dose radiation. 1023479. Palo Alto, CA: EPRI, Inc.

EPRI. 2014. Health and safety. http://www.epri.com/Our-Work/Pages/Health-and-Safety.aspx (accessed January 2, 2014).

FAA (Federal Aviation Administration). 2013. Radiobiology research team. www.faa.gov/data_research/research/med_humanfacs/aeromedical/radiobiology (accessed January 2, 2014).

FDA (Food and Drug Administration). 2011. Drugs: Emergency preparedness. http://www.fda.gov/Drugs/EmergencyPreparedness/default.htm (accessed January 2, 2014).

FDA. 2012. FDA radiological health program. http://www.fda.gov/Radiation-EmittingProducts/FDARadiologicalHealthProgram/default.htm (accessed January 2, 2014).

FDA. 2013. Office of Counterterrorism and Emerging Threats. http://www.fda.gov/EmergencyPreparedness/Counterterrorism/default.htm (accessed January 2, 2014).

LRRI (Lovelace Respiratory Research Institute). 2010. Researching the highs and lows of radiation. Breathe 3(1):10-12. www.lrri.org/Data/Sites/1/breathe/Breathe_Magazine_Fall_10.pdf (accessed January 2, 2014).

LRRI. 2014. Home page. http://www.lrri.org (accessed January 2, 2014).

NASA (National Aeronautics and Space Administration). 2009. NASA—Areas of study: Radiation. Human research program. http://www.nasa.gov/exploration/humanresearch/areas_study/environment/enviro_radiation.html (accessed January 2, 2014).

NASA. 2014. Space radiation research. NASA space radiation program element. http://spaceradiation.usra.edu/research (accessed January 2, 2014).

NCI (National Cancer Institute). Undated a. Radiation epidemiology branch: Understanding the link between radiation exposure and cancer. http://dceg.cancer.gov/reb/about (accessed January 2, 2014).

NCI. Undated b. Radiation research program. http://rrp.cancer.gov (accessed January 2, 2014).

NCRP (National Council on Radiation Protection and Measurements). 2012. SC 6-8: Operation TOMODACHI radiation dose assessment peer review. http://www.ncrponline.org/Current_Prog/SC_6-8.html (accessed January 2, 2014).

NCRP. 2014. Our mission. http://www.ncrponline.org/AboutNCRP/Our_Mission.html (accessed January 23, 2014).

NIAID (National Institute of Allergy and Infectious Disease). 2005. Radiation nuclear countermeasures introduction. http://www.niaid.nih.gov/topics/radnuc/program/Pages/introduction.aspx (accessed January 2, 2014).

NIAID. 2013. Radiation nuclear countermeasures. http://www.niaid.nih.gov/topics/radnuc/Pages/default.aspx (accessed January 2, 2014).

NIOSH (National Institute for Occupational Safety and Health). 2011. Occupational energy research program. http://www.cdc.gov/niosh/oerp/default.htm (accessed April 10, 2014).

NIOSH. 2014. NIOSH program area: Radiation dose reconstruction. http://www.cdc.gov/niosh/ocas/#drrev (accessed January 2, 2014).

NSBRI (National Space Biomedical Research Institute). 2012. NSBRI education & outreach selected program highlights. November 2012. http://www.nsbri.org/default/Education%20and%20Training/NSBRI_EO_Overview_nov12.pdf (accessed January 2, 2014).

NSBRI. Undated a. Radiation effects. www.nsbri.org/SCIENCE-and-TECHNOLOGY/Radiation-Effects (accessed January 2, 2014).

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

NSBRI. Undated b. Center for Acute Radiation Research. http://www.nsbri.org/SCIENCEand-TECHNOLOGY/Radiation-Effects/Team-Executive-Summary (accessed January 2, 2014).

ORAU (Oak Ridge Associated Universities). 2013. ORAU serves as co-investigator in study of radiation effects on one million U.S. workers. http://www.orau.org/occupational-exposureworker-health-studies/success-stories/million-worker-study.aspx (accessed December 6, 2013).

Pryor, K. 2013. The WARP initiative: Where are the radiation professionals? Health Physics News September.

RadCCORE (Radiation Countermeasures Center of Research Excellence). 2012. About us. http://www.radccore.org/about-us (accessed January 2, 2014).

U.S. NRC (Nuclear Regulatory Commission). 2013a. Research activities. http://www.nrc.gov/about-nrc/regulatory/research.html (accessed March 27, 2014).

U.S. NRC. 2013b. Backgrounder on analysis of cancer risk populations near nuclear facilities–Phase 2 pilot study. http://www.nrc.gov/reading-rm/doc-collections/fact-sheets/bg-analys-cancer-risk-study.html (accessed March 27, 2014).

U.S. NRC. 2013c. History. http://www.nrc.gov/about-nrc/history.html (accessed January 2, 2014).

U.S. NRC. 2014. Nuclear regulatory research. http://www.nrc.gov/about-nrc/organization/resfuncdesc.html#funcdesc (accessed March 27, 2014).

USTUR (U.S. Transuranium & Uranium Registries). 2007. About USTUR. http://www.ustur.wsu.edu/AboutUs/overview.html (accessed January 2, 2014).

VA (U.S. Department of Veterans Affairs). 2012. Research on health effects of radiation exposure. www.publichealth.va.gov/exposures/radiation/research.asp (accessed January 2, 2014).

VA. 2013. Radiation. www.publichealth.va.gov/exposures/radiation/index.asp (accessed January 2, 2014).

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

TABLE B-1 Websites of Research Programs That Address Low-Level Radiation Questions


Entity or Program     Primary Web Addressa

U.S. FEDERAL GOVERNMENT

Department of Defense

 

Defense Advanced Research Projects Agency

darpa.mil

Defense Threat Reduction Agency

dtra.mil

Department of Energy

 

Low Dose Radiation Research Program

science.energy.gov/ber/research/bssd/low-dose-radiation

Low Energy Nuclear Physics Research

science.energy.gov/np/research

Workforce Development for Teachers and Scientists

science.energy.gov/wdts

National Nuclear Security Administration

nnsa.energy.gov

National Aeronautics and Space Administration

 

Space Radiation Program

spaceradiation.usra.edu/research

National Space Biomedical Research Institute

nsbri.org/SCIENCE-and-TECHNOLOGY/Radiation-Effects

Center of Acute Radiation Research

nsbri.org/SCIENCE-and-TECHNOLOGY/Radiation-Effects/Team-Executive-Summary

Human Research Program

nasa.gov/exploration/humanresearch/areas_study/environment/enviro_radiation.html

Department of Health and Human Services

 

National Cancer Institute

 

Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch

dceg.cancer.gov/reb/about

Radiation Research Program

rrp.cancer.gov

Developmental Therapeutic Program

dctd.cancer.gov/ProgramPages/dtp/default.htm

National Institutes of Health

 

National Institute of Allergy and Infectious Diseases

niaid.nih.gov/Pages/default.aspx

Radiation and Nuclear Countermeasures Program

www.niaid.nih.gov/topics/radnuc/program/Pages/introduction.aspx

 

niaid.nih.gov/topics/radnuc/Pages/default.aspx

Centers for Medical Countermeasures against Radiation

www.niaid.nih.gov/topics/radnuc/Documents/cmcr_project_descriptions.pdf

Office of the Assistant Secretary for Preparedness and Response

 

Biomedical Advanced Research and Development Authority

phe.gov/about/barda/Pages/cbrn.aspx

Division of Chemical, Biological, Radiological and Nuclear Medical Countermeasures

www.phe.gov/about/barda/Pages/cbrn.aspx

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

Entity or Program     Primary Web Addressa

Food and Drug Administration

 

Center for Devices and Radiological Health

fda.gov/Radiation-EmittingProducts/FDARadiologicalHealthProgram/default.htm

Center for Drug Evaluation and Research

fda.gov/Drugs/EmergencyPreparedness/default.htm

Office of Counterterrorism and Emerging Threats

fda.gov/EmergencyPreparedness/Counterterrorism/default.htm

Centers for Disease Control and Prevention

 

Agency for Toxic Substances and Disease Registry

atsdr.cdc.gov

National Institute of Occupational Safety and Health

 

Occupational Energy Research Program

http://www.cdc.gov/niosh/oerp/default.htm

Radiation Dose Reconstruction Program

cdc.gov/niosh/ocas/ocasdose.html

Flight Crew Research Program

cdc.gov/niosh/topics/flightcrew

Federal Aviation Administration

 

Radiobiology Research Team

faa.gov/data_research/research/med_humanfacs/aeromedical/radiobiology

Environmental Protection Agency

 

Radiation Protection Program

epa.gov/radiation/basic/index.html

Department of Veterans Affairs

 

Public Health Epidemiology Program

publichealth.va.gov/exposures/radiation/index.asp

Epidemiology Program

publichealth.va.gov/exposures/radiation/research.asp

Department of State

 

Bureau of International Security and Nonproliferation

state.gov/t/isn/index.htm

Bureau of Counterterrorism

state.gov/j/ct

Nuclear Regulatory Commission

nrc.gov/about-nrc/history.html

SELECTED PRIVATE AND ACADEMIC INITIATIVES

 

Lovelace Respiratory Research Institute

lrri.org

Center for High-Throughput Minimally Invasive Radiation Biodosimetry

cmcr.columbia.edu

U.S. Transuranium and Uranium Registry

ustur.wsu.edu

SELECTED NONPROFIT ORGANIZATIONS

National Council on Radiation Protection and Measurements

ncrponline.org

Electric Power Research Institute

epri.com

Radiation Countermeasures Center of Research Excellence

radccore.org/home


a Addresses valid on January 24, 2014.

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×

This page intentionally left blank.

Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 135
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 136
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 137
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 138
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 139
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 140
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 141
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 142
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 143
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 144
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 145
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 146
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 147
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 148
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 149
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 150
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 151
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 152
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 153
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 154
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 155
Suggested Citation:"Appendix B: U.S. Radiation Research Programs." Institute of Medicine and National Research Council. 2014. Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute. Washington, DC: The National Academies Press. doi: 10.17226/18732.
×
Page 156
Next: Appendix C: Biographic Sketches of Committee Members and Staff »
Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute Get This Book
×
Buy Paperback | $50.00 Buy Ebook | $40.99
MyNAP members save 10% online.
Login or Register to save!
Download Free PDF

It is probably only a matter of time before we witness the next event in which large numbers of people are exposed to ionizing radiation. In the past, planning a response to such an occurrence would have likely focused on the management of casualties from high-dose exposure. However, more recently, a different threat has come to the fore: accidental (through a containment breach in a nuclear power plant, for example) or intentional (via a "dirty bomb") releases of radioactivity resulting in low-dose exposure to a population. The magnitude of the health risks arising from low-dose radiation exposure is uncertain, and this uncertainty has significant economic implications for public health decision making.

Research on Health Effects of Low-Level Ionizing Radiation Exposure examines recent scientific knowledge about the human effects of exposure to low-dose radiation from medical, occupational, and environmental ionizing-radiation sources. This report is intended to provide advice to the Armed Forces Radiobiology Research Institute (AFRRI) about its role in low-dose radiation health effects research. The report identifies current research directions in radiobiological science and assesses how AFRRI programs are advancing research along these directions. The recommendations of Research on Health Effects of Low-Level Ionizing Radiation Exposure will provide guidance for AFRRI to build on its strengths and advance its mission while contributing to the body of scientific knowledge on the health effects of exposure to low-dose ionizing radiation.

  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    Switch between the Original Pages, where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text.

    « Back Next »
  6. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  7. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  8. ×

    View our suggested citation for this chapter.

    « Back Next »
  9. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!