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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Page 66
Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Page 67
Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Page 68
Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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Suggested Citation:"References." Institute of Medicine. 2015. Review of NASA's Evidence Reports on Human Health Risks: 2014 Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/18983.
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58 REVIEW OF NASA’S EVIDENCE REPORTS ON HUMAN HEALTH RISKS Aviles, H., T. Belay, M. Vance, and G. Sonnenfeld. 2005. Effects of space flight conditions on the function of the immune system and catecholamine pro- duction simulated in a rodent model of hindlimb unloading. Neuroimmuno- modulation 12(3):173-181. Baatout, S., A. Choukèr, I. Kaufmann, N. Montano, S. Praun, D. de Quervain, B. Roozendaal, G. Schelling, and M. Thiel. 2012. Space travel: An integra- tive view from the scientists of the topical team “stress and immunity.” In Stress Challenges and Immunity in Space, edited by A. Choukèr. Berlin: Springer-Verlag. Pp. 5-10. Bainbridge, W. S. 2010. Online Multiplayer Games. San Rafael, CA: Morgan & Claypool Publishers. Barshi, I. 2012. NASA evidence report: Risk of performance errors due to training deficiencies. http://humanresearchroadmap.nasa.gov/evidence/reports/Train.pdf (accessed November 30, 2014). Beer, J. M., A. D. Fisk, and W. A. Rogers. 2014. Toward a framework for levels of robot autonomy in human-robot interaction. Journal of Human-Robot In- teraction 3(2):74-99. Belay, T., H. Aviles, M. Vance, K. Fountain, and G. Sonnenfeld. 2002. Effects of the hindlimb-unloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniae. Journal of Allergy and Clini- cal Immunology 110(2):262-268. Bellamy, W. 2013. Honeywell touchscreen research guides FAA regulation. Aviation Today. http://www.aviationtoday.com/av/topstories/Honeywell- Touchscreen-Research-Guides-FAA-Regulation_80749.html#.VDU8m_l4 ptB (accessed November 30, 2014). Boyle, E., M. Al-Akash, A. G. Gallagher, O. Traynor, A. D. K. Hill, and P. C. Neary. 2011. Optimising surgical training: Use of feedback to reduce errors during a simulated surgical procedure. Postgraduate Medical Journal 87(1030):524-528. Cabibihan, J., W. So, and S. Pramanik. 2012. Human-recognizable robotic ges- tures. IEEE Transactions on Autonomous Mental Development 4(4):305- 314. Caldwell, E., M. Gernhardt, J. T. Somers, D. Younker, and N. Newby. 2012. NASA evidence report: Risk of injury due to dynamic loads. http:// humanresearchroadmap.nasa.gov/Evidence/reports/Occupant%20Protection.pdf (accessed November 30, 2014). Castro, S. L., M. Nelman-Gonzalez, C. A. Nickerson, and C. M. Ott. 2011. In- duction of attachment-independent biofilm formation and repression of Hfq expression by low-fluid shear culture of Staphylococcus aureus. Applied and Environmental Microbiology 77(18):6368-6378.

REFERENCES 59 Chatterjee, A., S. Bhattacharya, and C. M. Ott. 2012. NASA evidence report: Risk of adverse health effects due to alterations in host-microorganism interactions. http://humanresearchroadmap.nasa.gov/evidence/reports/Microhost (accessed September 23, 2014). Cohrs, R. J., S. K. Mehta, D. S. Schmid, D. H. Gilden, and D. L. Pierson. 2008. Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts. Journal of Medical Virology 80(6):1116-1122. Crabbé, A., P. De Boever, R. Van Houdt, H. Moors, M. Mergeay, and P. Corneis. 2008. Use of the rotating wall vessel technology to study the effect of shear stress on growth behavior of Pseudomonas aeruginosa PA01. Environmen- tal Microbiology 10(8):2098-2110. Crabbé, A., M. J. Schurr, P. Monsieurs, L. Morici, J. Schurr, J. W. Wilson, C. M. Ott, G. Tsaprailis, D. L. Pierson, H. Stefanyshyn-Piper, and C. A. Nickerson. 2011. Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and re- veal a role for oxygen. Applied and Environmental Microbiology 77(4):1221-1230. Crabbé, A., S. M. Nielsen-Preiss, C. M. Woolley, J. Barrila, K. Buchanan, J. McCracken, D. O. Inglis, S. C. Searles, M. A. Nelman-Gonzalez, C. M. Ott, J. W. Wilson, D. L. Pierson, H. M. Stefanyshyn-Piper, L. E. Hyman, and C. A. Nickerson. 2013. Spaceflight enhances aggregation and random budding in Candida albicans. PLoS ONE 8(12):e80677. Cristancho, S. M., T. Apramian, M. Vanstone, L. Lingard, M. Ott, and R. J. Novick. 2013. Understanding clinical uncertainty: What is going on when experienced surgeons are not sure what to do? Academic Medicine 88(10):1516-1521. Cristancho, S. M., S. J. Bidinosti, L. A. Lingard, R. J. Novick, M. C. Ott, and T. L. Forbes. 2014. What’s behind the scenes? Exploring the unspoken dimen- sions of complex and challenging surgical situations. Academic Medicine 89(11):1540-1547. Crucian, B., and C. Sams. 2009. Immune system dysregulation during space- flight: Clinical risk for exploration-class missions. Journal of Leukocyte Bi- ology 86(5):1017-1018. Crucian, B. E., R. P. Stowe, D. L. Pierson, and C. F. Sams. 2008. Immune sys- tem dysregulation following short- vs long-duration spaceflight. Aviation, Space, and Environmental Medicine 79(9):835-843. Crucian, B., R. P. Stowe, C. M. Ott, J. L. Becker, R. Haddon, K. A. McMonigal, and C. F. Sams. 2009. NASA evidence report: Risk of crew adverse health event due to altered immune response. http://humanresearchroadmap. nasa.gov/Evidence/reports/Immune.pdf (accessed November 26, 2014). Crucian, B. E., R. P. Stowe, S. Mehta, P. Uchakin, H. Quiriarte, D. Pierson, and C. Sams. 2013. Immune system dysregulation occurs during short duration spaceflight on board the space shuttle. Journal of Clinical Immunology 33(2):456-465.

60 REVIEW OF NASA’S EVIDENCE REPORTS ON HUMAN HEALTH RISKS Crucian, B., R. J. Simpson, S. Mehta, R. Stowe, A. Choukèr, S.-A. Hwang, J. K. Actor, A. P. Salam, D. Pierson, and C. Sams. 2014a. Terrestrial stress ana- logs for spaceflight associated immune system dysregulation. Brain, Behav- ior, and Immunity 39:23-32. Crucian, B. E., S. R. Zwart, S. Mehta, P. Uchakin, H. D. Quiriarte, D. Pierson, C. F. Sams, and S. M. Smith. 2014b. Plasma cytokine concentrations indi- cate that in vivo hormonal regulation of immunity is altered during long- duration spaceflight. Journal of Interferon & Cytokine Research 34(10):778-786. Cucinotta, F. A., and M. Durante. 2009. NASA evidence report: Risk of radia- tion carcinogenesis. http://humanresearchroadmap.nasa.gov/evidence/reports/ Carcinogenesis.pdf (accessed November 30, 2014). Cucinotta, F. A., H. Wang, and J. L. Huff. 2009. NASA evidence report: Risk of acute or late central nervous system effects from radiation exposure. http://humanresearchroadmap.nasa.gov/evidence/reports/CNS.pdf (accessed November 30, 2014). DeSteno, D., C. Breazeal, R. H. Frank, D. Pizarro, J. Baumann, K. Dickens, and J. J. Lee. 2012. Detecting trustworthiness of novel partners in economic ex- change. Psychological Science 23(12):1549-1556. Fiore, S. M., T. J. Wiltshire, E. J. C. Lobato, F. Jentsch, W. H. Huang, and B. Axelrod. 2013. Towards understanding social cues and signals in human- robot interaction: Effects of robot gaze and proxemic behavior. Frontiers in Psychology: Cognitive Science 4:859. Foster, J. S., C. L. M. Khodadad, S. R. Ahrendt, and M. L. Parrish. 2013. Impact of simulated microgravity on the normal developmental time line of an an- imal-bacteria symbiosis. Scientific Reports 3:1340. Foster, J. S., R. M. Wheeler, and R. Pamphile. 2014. Host-microbe interactions in microgravity: Assessment and implications. Life 4(2):250-266. Gawande, A. 2013. The checklist manifesto: How to get things right? New York: Henry, Holt and Company. Gernhardt, M., J. A. Jones, R. A. Scheuring, A. F. Abercromby, J. A. Tuxhorn, J. R. Norcross. 2009. NASA evidence report: Risk of compromised EVA per- formance and crew health due to inadequate EVA suit systems. http://humanresearchroadmap.nasa.gov/Evidence/reports/EVA%20Suit.pdf (accessed November 30, 2014). Goncharova, G. I., N. N. Liz’ko, A. M. Lyannaya, V. M. Shilov, T. I. Spitsa, G. D. Syrykh, and V. A. Kazantsev. 1981. Status of cosmonaut Bifidoflora before and after spaceflight. Kosmicheskaya Biologiya I Aviakosmichekaya (in Russian) 15(3):14-18. Grant, K. A., C. L. M. Khodadad, and J. S. Foster. 2014. Role of Hfq in an animal- microbe symbiosis under simulated microgravity conditions. International Journal of Astrobiology 13(1):53-61. Griffin, M. J. 2001. The validation of biodynamic models. Clinical Biomechanics 16(Suppl. 1):S81-S92.

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Review of NASA's Evidence Reports on Human Health Risks 2014 Letter Report is the second in a series of five reports from the Institute of Medicine that will independently review more than 30 evidence reports that the National Aeronautics and Space Administration has compiled on human health risks for long-duration and exploration space flights. This report builds on the 2008 IOM report Review of NASA's Human Research Program Evidence Books: A Letter Report, which provided an initial and brief review of the evidence reports.

This letter report reviews seven evidence reports and examines the quality of the evidence, analysis, and overall construction of each report; identifies existing gaps in report content; and provides suggestions for additional sources of expert input. The report analyzes each evidence report's overall quality, which included readability; internal consistency; the source and breadth of cited evidence; identification of existing knowledge and research gaps; authorship expertise; and, if applicable, response to recommendations from the 2008 IOM letter report.

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