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Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
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A

Workshop Agenda

Applying an Implementation Science Approach to
Genomic Medicine: A Workshop

November 19, 2015

National Academy of Sciences Building
Lecture Room
2101 Constitution Avenue, NW
Washington, DC

MEETING OBJECTIVES

  • To elucidate options for accelerating the pace of implementation and evidence generation in genomic medicine by convening medical implementation science experts with stakeholders representing the continuum of genomics translational research.
  • To discuss possible strategies for reaching and engaging diverse populations when introducing genomic medicine into practice.
  • To explore the challenges, successes, and best practices that facilitate rapid and appropriate translation of genomic knowledge from early discovery to population health.
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
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AGENDA

8:30–8:35 a.m. Welcoming Remarks
Sharon F. Terry, Roundtable Co-Chair
President and Chief Executive Officer
Genetic Alliance
Geoffrey Ginsburg, Roundtable Co-Chair
Director, Duke Center for Applied Genomics & Precision Medicine; Professor of Medicine and of Pathology and Biomedical Engineering, Duke University Medical Center

INTRODUCTION: OPPORTUNITIES IN GENOMICS THAT CHALLENGE THE TRADITIONAL IMPLEMENTATION PATHWAY

Objectives: To define and explore the stages and roles of implementation science from basic science discoveries to advancing genomic medicine in routine clinical care
8:35 a.m. Charge to Workshop Speakers and Participants: Considering the Role of Implementation Science Across the Translational Spectrum in Genomics
Greg Feero, Workshop Co-Chair
Associate Editor, Journal of the American Medical Association; Faculty, Maine Dartmouth Family Medicine Residency Program
Debra Leonard, Workshop Co-Chair
Professor and Chair of Pathology and Laboratory Medicine
University of Vermont Medical Center
8:45 a.m. Overview of Implementation Science: Methods and Approaches
David Chambers
Deputy Director for Implementation Science National Cancer Institute
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Brian Mittman
Research Scientist III, Research & Evaluation
Kaiser Permanente Research
Senior Advisor, Veterans Affairs Center for Implementation Practice and Research Support, Los Angeles, CA
Consultant, University of California, Los Angeles, Institute for Innovation in Health
Senior Advisor, RAND Health
9:30 a.m. Clarifying Questions

SESSION I: DESIGNING FOR IMPLEMENTATION: ENGAGING LARGE POPULATIONS FOR ANALYSIS

Objectives: To assess best practices for engaging diverse patient and provider groups and evaluating how information collected from large groups could be leveraged for discovery efforts and improved health outcomes
Moderator: Bruce Blumberg, Institutional Director of Graduate Medical Education, Northern California Kaiser Permanente
9:40 a.m. Andrew Faucett
Director of Policy and Education
Geisinger Health System
Consuelo H. Wilkins
Executive Director, Meharry-Vanderbilt Alliance
Associate Professor of Medicine
Vanderbilt-Ingram Cancer Center
Marc LePage
President and Chief Executive Officer
Génome Québec
10:30 a.m. Break
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
10:45 a.m. Discussion with Speakers, Reactants, and Attendees
Speakers
Andrew Faucett
Consuelo H. Wilkins
Marc LePage
Reactants
Bernice Coleman
Nurse Scientist and Nurse Practitioner
Heart Transplantation and Mechanical Assist Device Programs, Cedars Sinai Medical Center, Los Angeles
Robert McDonough
Head of Clinical Policy Research & Development
Aetna
Brian Mittman
Research Scientist III, Research & Evaluation
Kaiser Permanente Research
Senior Advisor, Veterans Affairs Center for Implementation Practice and Research Support, Los Angeles, CA
Consultant, University of California, Los Angeles, Institute for Innovation in Health
Senior Advisor, RAND Health
Jane Perlmutter
President and Founder
Gemini Group
Alexandra Shields
Associate Professor, Harvard Medical School and Massachusetts General Hospital (MGH)
Director, Harvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×

SESSION II: EXPLORING MODELS FOR IMPROVING IMPLEMENTATION WHILE GENERATING EVIDENCE IN CLINICAL SETTINGS

Objective: To explore case studies where implementation in clinical care has had varying degrees of success in achieving practice change
Moderator: Catherine Wicklund, Past President,
National Society of Genetic Counselors
Director, Graduate Program in Genetic Counseling, Northwestern University
11:30 a.m. Approaches to Implementation
Edward Kim
Chair, Solid Tumor Oncology and Investigational Therapeutics and the Donald S. Kim Distinguished Chair for Cancer Research
Levine Cancer Institute, Carolinas HealthCare System
Mary Norton
Professor of Obstetrics, Gynecology, and Reproductive Sciences
University of California, San Francisco
Stephen Kimmel
Professor of Medicine
University of Pennsylvania School of Medicine
12:20 p.m. Discussion with Speakers, Reactants, and Attendees
Speakers
Edward Kim
Mary Norton
Stephen Kimmel
Reactants
Bernice Coleman
Robert McDonough
Brian Mittman
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Jane Perlmutter
Alexandra Shields
1:00 p.m. WORKING LUNCH

SESSION III: POPULATION HEALTH AND GENOMICS: INCREMENTAL IMPLEMENTATION OR RADICAL REFORM?

Objectives: To explore effective strategies and infrastructure that facilitates implementation and how these could be applied to advance the future of genomic medicine
Moderator: Greg Feero, Workshop Co-Chair;
Associate Editor, Journal of the American Medical Association; and Faculty, Maine Dartmouth Family Medicine Residency Program
2:00 p.m. Deb Duquette
Genomics Coordinator
Michigan Department of Health and Human Services
Marc LePage
President and Chief Executive Officer
Génome Québec
Toni Pollin
Associate Professor, Medicine
University of Maryland School of Medicine
2:50 p.m. Discussion with Speakers, Reactants, and Attendees
Speakers
Deb Duquette
Marc LePage
Toni Pollin
Reactants
Bernice Coleman
Robert McDonough
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Brian Mittman
Jane Perlmutter
Alexandra Shields
3:30 p.m. Break

SESSION IV: ACHIEVING THE VISION

Objectives: To reflect on the potential value of implementation science to the translation of genomics to achieve improved health outcomes. To provide concrete examples of how integration of principles of implementation science might accelerate the translational pipeline now and over the next 5–10 years.
Moderator: Debra Leonard, Workshop Co-Chair;
Professor and Chair of Pathology and Laboratory Medicine, University of Vermont Medical Center
3:45 p.m. Stakeholder Reaction Panelists
Health Care Provider Perspective
Bernice Coleman
Payer Perspective
Bob McDonough
Patient Perspective
Jane Perlmutter
Health Disparities Perspective
Alexandra Shields
4:20 p.m. Discussion with Reactants and Attendees
5:00 p.m. Concluding Remarks
Summary of Important Points and Potential Approaches to Genomic Medicine Implementation
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
David Chambers
Deputy Director for Implementation Science
National Cancer Institute
5:20 p.m. Adjourn
Greg Feero, Workshop Co-Chair
Associate Editor, Journal of the American Medical Association; Faculty, Maine Dartmouth Family Medicine Residency Program
Debra Leonard, Workshop Co-Chair
Professor and Chair of Pathology and Laboratory Medicine
University of Vermont Medical Center
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 71
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 72
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 73
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 74
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 75
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 76
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 77
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2016. Applying an Implementation Science Approach to Genomic Medicine: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/23403.
×
Page 78
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Although it is becoming increasingly more common for clinicians to use genomic data in their practices for disease prevention, diagnosis, and treatment, the process of integrating genomic data into the practice of medicine has been a slow and challenging one. Some of the major barriers impeding the incorporation of new genomic technology into clinical practice are: the difficulty of changing routine medical practices to account for the use of genetic testing, the limited knowledge of patients and providers about genomic medicine, assessing sufficient evidence to support the use of genetic tests, privacy and data security issues, and uncertainty about reimbursement.

The field of implementation science may be able to provide insights concerning efficient ways to incorporate genomic applications into routine clinical practice. The focus of implementation science studies is to identify integration bottlenecks and optimal approaches for a given setting and ultimately to promote the up-take of research findings. To explore the potential of implementation science to improve the integration of genomics into medicine, the National Academies of Sciences, Engineering, and Medicine held a workshop in Washington, DC, in November 2015. Participants explored the challenges and opportunities of integrating genomic advances into the clinic through the lens of implementation science. This report summarizes the presentations and discussions from the workshop.

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