National Academies Press: OpenBook
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R1
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R2
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R3
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R4
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R5
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R6
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R7
Page viii Cite
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R8
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R9
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R10
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R11
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R12
Page xiii Cite
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R13
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R14
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R15
Suggested Citation:"Front Matter." National Research Council. 1996. Guide for the Care and Use of Laboratory Animals -- Russian Version. Washington, DC: The National Academies Press. doi: 10.17226/10498.
×
Page R16

Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

PYKOBO~CTBO HO CO~EP~HHIO ~ IICtIOJIb30BAHIIlO JIAI3OPATOPHbIX ~IIBOTHbIX Ha~HOHa~bHMU HayqHO-HCC~e~OBaTe~bC~H COBeT KOMUCC~ HO HaYKaM O ~3HU I IHCTHTYT PeCYPCOB ~a60PaTOPHb~ ~BOTHb~ NATIONAL ACADEMY PRESS Washington, D.C.

PYKOBO,~CTBO HO CO,~eP*aHHIO ~ ~CHO~bSOBaHHIO ~a60PaTOPH~X ~BOTH~X. rIepeso,~ c aHr~ncKoro. PYKOBO,~CTBO, HaHUCaHHOe KO~eKTHBOM Be,~Y~UX CHeUHaRUCTOB CIIIA, OXBaT~BaeT PaS~HHMe aCHeKTM CO,~eP*aHHR ~ ~CHO~bSOBaHHR ~a60PaTOPH~X *HBOTH~X B HEX ~CC~e~OBaH~X, TeCTHpOBaHHU ~ oGy~eHnn. Hpe~Ha~Ha~eHo ~~ COTpy~H~KOB BUBaPHR, HaY~H~X Pa60TH~KOB, BeTeP~HaPOB, B 06~3aHHOCTH KOTOP~X BXO,~HT 06Pa~eHHe C ~a60PaTOPH~MU *HBOTH~M~, a TaK*e cTy~eHTos cooTseTcTsy~om~x 6no~or~ecKnx, Me~HHCKHX ~ Ce~bCKOXO3~HCTBeHH~X CHe~Ha~bHOCTeH. NATIONAL ACADEMY PRESS · 2101 Constitution Avenue, NW · Washington, DC 20418 TIPUMeHaHHe: ,QaHHMU HPOeKT, KOTOPMU COCTaB~HeT HPe,~MeT HaCTOH~erO ~OKyMeHTa, 6bM yTBep~eH ~paB~eHHeM Ha~HOHa~bHOrO Hay~HO-HCC~e~OBaTe~bCKOrO COBeTa, ~eHM KOTOPOrO BXO,~HT B COCTaB IIPeS=HYMOB HaLIHOHaRbHOH aKa,~eMHU HaYK, Ha~HOHa~bHOH TeXHHHeCKOH aKa~eMun ~ ~HCTHTyTa Me~HHbI. BbI60p H~eHOB KOMuTeTa, Ha KOTOpbIn 6bMa BOS~O*eHa OTBeTCTBeHHOCTb Sa nO,~rOTOBKy HacToH~ero ,~OKyMeHTa, OCy~eCTB~CH C y~eTOM uX KOMneTeHTHOCTH B ,~aHHOn o6~acTH ~ o6~ero 6a~aHca. HacToH~n ,~OKyMeHT 6bI~ paCCMOTpeH rpynnon HeSaBuCHMbIX 3KCHepTOB B COOTBeTCTBlIlI C IIpOLle,~ypaM~, yTBep~eHHbIMlI KOMlITeTOM IIO pe~eH3HpOBaHHIO, COCTOH~HM HS H~eHOB Ha~HoHa~bHon aKa,~eMHn HayK, Ha~HoHaRbHon TeXH~eCKOn aKa,~eMun ~ i]HCTHTyTa Me~HHbI. ,jaHHbIn IIpOeKT 6bLR OCy~eCTB~eH IIpH IIO,~ep*Ke rlporpaMMbI IIO CpaBHuTe~bHOn Me~HHe Ha~HOHa~bHOrO ~eHTpa ~CC~e~OBaTe~bCKHX peCypCOB Me*Be~OMCTBeHHOrO KoMuTeTa no 3KcHepuMeHTa~bHbIM *HBOTHbIM ~ y~paB~eH~q no 3a~nTe OT PUCKa HPH HpOBe,~eHHn Hay~HbIX nCC~e,~OBaHHn Ha~HOHaRbHbIX nHCTHTyTOB 3,~OpOBb~ ~ C~y*6bI 3~paBOOXpaHeH~, a TaK*e M~HUCTepCTBa Ce~bCKOrO X03~HCTBa C~A ~ Y~paB~eHHR IIO ~e~aM BeTepaHOB. ~pOeKT +HHaHCHpyeTCH B paMKaX ~pOrpaMMbI H0 CpaBHUTe~bHOH Me,~HHe HaU~OHa~bHOrO ~eHTPa ~CC~e,~OBaTe~bCKHX PeCYPCOB HO rPaHTY NIH RR08779-02. OCHOBHa5[ +HHaHCOBaH HO~ep*Ka ~HCTHTyTa peCypCOB ~a60paTOpHbIX ~BOTHbIX OCy~eCTB~HeTCH ~]pOrPaMMOH H0 CpaBHUTe~bHOH Me~nHe Ha~HOHa~bHOrO ~eHTpa ~CC~e~OBaTe~bCKHX peCypCOB HaU~OHa~bHbIX UHCTHTyTOB 3~0pOBb~ H0 rpaHTy N° 5P40RRO137; HaU~OHa~bHbIM Hay~HbIM ~OH~OM H0 rpaHTy N° BIR-9024967; KOMaH~OBaHHeM Hay~HbIX ~CC~e~OBaHHU ~ pa3pa60ToK Me~HHCKOH C~6bI apMHU CIIIA, KOTOpOe BbICTyIIaeT B pO]IlI Be~y~erO areHTCTBa, +HHaHCHpyeMOrO B paMKaX M~HUCTepCTBa 060pOHbI CIIIA Y~paB~eHHeM He~OBeHeCKHX CHCTeM KOMaH~OBaH~ BB C CIIIA, IIHCTHTYTOM pa~HO6~0~0rHHeCKHX ~CC~e~OBaHHU BOOpy~eHHbIX CH~, YHUBepCHTeTOM 3,~pasooxpaHeHn~ BOOpy~eHHbIX cu~ ~ KOMaH~OBaHHeM Hay~HbIX nCC~e,~OBaHHU ~ pa3pa6oToK Me,~UHHCKOH C~y*6bI BMC CWA HO rPaHTY N° DAMD- 17-93-J-3016; ~ AMeP~KaHCK~M OHKO~OrHHeCK~M 06~eCTBOM H0 rPaHTY ,~ HaY~HO- ~CC~e,~OBaTe~bCKHX IIPOeKTOB N° RC- 1 -34. MHeH~q, nO~y~eHHbIe ,~aHHbIe, a TaK*e BbIBO,~bI ~n peKOMeH,~aUnn, H3~o~eHHbIe B ,~aHHOn rIy6~nKaUnn' He scer,~a OTpa~alOT TO~Ky 3peHHR C~y*6bI 3~pasooxpaHeHHR n ,~pyrux CHOHCOpOB. ynoM~HaHne TOprOBbIX MapOK, KOMMepHeCKHX HpO,~yKTOB ~n opraHn3aunn TaK*e He RB~HeTCH CBH~eTe~bCTBOM o~o6peHn~ rOCy~apCTBeHHbIMU y~pe~eH~qMn CIIIA ~n ,~pyrnMn CHOHCOpaMH. ISBN 0-309-05377-3 Copyright 1996 bY the National Academy of Sciences. A11 rights reserved.

lIPlIME'IAHlIE IlepsMn BapHaHT <<pyKoBo,QcTBa rIo co,Qep~aHHIo ~ nCrIO~bsOBaHHIO a6opaTopHux *HBOTHuX>> rIOCTyrIn~ B pacrIop~*eHHe CrIOHCOpOB o6mecTBeHHocTn 2 slap 1996 r. troche aTOrO [IHCTHTYT pecypcoB ~a6opaTopHux BOTHuX (ILAR - Institute of Laboratory Animal Resources) rIo~Tyq~ saMeHaH~ OT HO~b3OBaTe~eH ~ ROB KOMUTeTa HO HepeCMOTpy ~KOffO0Cmffa. ~KOffO0CmffO scer,Qa paCCMaTpuBaJIOCb KaK carbon ,QOKyMeHT, Tpe6ylo~H BHeCeHH~ rIOrIpaBOK rIo Mepe HaMeHeH~ yC~OBHn ~ rIO~B~eHH~ HOBOn nH+OpMapHH. c~e,QcTBueM TaKOn rIOCu~KH ~B~eTC~ rIocTo~HHun aKLleHT Ha rIpaKTHHeCKne pesy~bTaTM ncrIo~bsoBaH~ py~coffodcmffa' a He Ha ~opMa~bHoe co6~Io,QeHHe ero peKoMeH,~apHH. OplIeHTapH~ Ha HpaKTHHeCKylO peSy~bTaTHBHOCTb sos~araeT HOBM~eHHylO OTBeTCTBeHHOCTb Ha rIo~b3osaTe~ ~, KaK C~e,QCTBue, Tpe6yeT oco60H 3a6oTbI O COCTOf[HlIlI ~IBOTHLIX; O~HaKO TaKOH HO~XO~ Hpe~HO~araeT OCTOpO*HOe OTHO~eHHe K nHTeprIpeTaLlHn Tpe6oBaHHH' Tor,Qa KaK ~OpMaJIbHun rIo,Qxo,~ He OCTaB~eT MeCTa ,=~ pa3JIn~Hux TOJIKOBaHHH. IlaM~Ty~ O TaKOM pa3JInHHH' H. aLlHOHaJIbHun Hay~HO- ~CC~e~OBaTe~bCKHU COBeT ~ Ha3HaHeHHMe HM pepeH3eHTM CTpeM~HCb ~06nTbC~ MaKCHMa~bHOH TO~HOCTH ~ ~CHOCTH H3~0*eHH~. TeM He MeHee, HUTaTe~H HepBOrO BapHaHTa P.y]COffO0Cmffa 06Hapy*~H B HeM pe~H p~Q 0~60K ~ HeTO~HOCTen. HeKoTopMe HuTaTe~H 3aMeT~H 0~6KH B HyMepapHU CTpaHHp, op~orpa+~H 6~6~Horpa+~. ,0;pyrne HuTaTe~H OTMeT~H HelIpaB~bHOe TO~KOBaHHe HeKOTOp~X r~o~o~eHnn Py~cosodcmea. Iloc~e TmaTe~bHoro n3y~eHn~ r~o~y~eHHux 3aMe~aHnn B pyKOHUCb 6~H BHeCeHM ~CHpaB~eHH~. H aDpUMep, 6~H ~CHpaB~eHM HyHKTyapHOHHMe ~ Op+Orpa+~HeCKHe 0~6K~, yTO~HeHM paCH~MBHaTMe ~OpMy~HpOBKH. ~pUMepOM H3MeHeHHU, HaDpaB~eHH~X Ha yTO~HeHHe CM~C~a, MO*eT C~y*HTb 3aMeHa C~OBa <<pa3paGaTusaTb>> C~OBaMU <<paCCMaTpUBaTb yTsep*~aTb>> TaM, r~e pe`Ib lI~eT 0 ~yHKpHU KOMUCCHU H0 CO~ep~aHHIO ~CHO~b30BaHHI0 ~BOTH~X, C03~aHHOH HpH y~pe~eHHn (InstitutionalAnimal Care and Use Committee - IACUC) B OTHO~eHHU H~aHOB CTpOUTe~bCTBa BUBapH~, C06~10~eH~ rUrHeHHHeCKHX HOpM ~ BM60pa HO~CT~O~HOrO MaTepHa~a- HOC~e~HHe BXO~T B o6~3aHHocTH COTpy~H~KOB BUBap~, a He ~eHos IACUC, KaK 3TO MO*eT c~e,QoBaTb H3 c~oBa <<pa3pa6aTusaTb>>. ~pa3a o KoHTpo~e 3a orpaHHHeHHeM rIoTpe6~eHH~ KOpMa ~ *n,QKOCTH Me~K~Mn *HBOTHuMn 6~a yTO~HeHa rIoc~e BHeCeHH~ C~OB <<HarIpuMep' rpu3yHaMH>>.tInTaTe~en pyKOrInCH rIpoc~H BHeCTH rIpe,~o~eHH~ B OTHOmeHHn opraHH3apHH' KOTOpMe ,QO~HM 6uTb BK~IOHeHM B rIp~o~eHHe ~ (<<opraHH3aLlHH' HMelo~He oTHoIIIeHHe K HayKe 0 JIa6opaTopHux ~BOTHuX>>~; HeKoTopMe rIpe,~o~eH~ 6bL11H y~TeHM rIpH rIo,QroToBKe rly6JInKaLlHH. cHocKa Ha CTp. 2 OpHr~Ha~a, Ha KOTOpylO HMelOTC~ TpH CCu~KH B TeKcTe P.y]COffO0Cmffa, HaHOM~HaeT HUTaTe~M O TOM, HTO P.y~cosodcmeo ope~Ha3Ha~eHo ~ mnpOKOn Me;K,D;yHapO,QHOn ay,~nTopHH' HaCTb KOTOpOn He o6~3aHa BurIo~H~Tb Tpe60BaHH~ ~ CO,Qep~a~HeC~ B IlpaBHJIaX lIO ryMaHHOMy CO,Qep~aHHIO ~CHO~b30BaHUIO ~a60paTOpHbIX ~BOTHbIX C~6bI 3~paBooxpaHeH~ C~A ~n B IIOCTaHOB~eHHU O 3a~HTe *HBOTHbIX. IlpH 3TOM C~e~yeT HOMHUTb, HTO opraHH3aLlHn ~ oT,Qe~bHbIe ~HLla, Ha KOTOpbIe paCTIpOCTpaH,[IOTC~ 3TH HpaB~a, ~O~HbI C06~IO~aTb UX ~a~e B Tex c~a~x, B KOTOpbIX Py~OffO0CmffO peKOMeH~yeT UHbIe HO~XO~bI. HeCMOTp~ Ha TO, HTO TaKOe Hpe~y~pe~eHHe HeO~HOKpaTHO BCTpe`IaeTC,[ B TeKCTe py~coffodcmffa' ero COCTaBuTeJIn CO~JIn HeO6XO,~HMbIM OCTaHOBUTbC~ Ha HeM BO BBe~eHHH. COTPY~H~KH ~HCTHTyTa peCypCOB 0paTOpHbIX *HBOTHbIX HO~araIOT, HTO yHOM~HyTbIe yTO~HeHH~ HOMOryT HO~b30BaTe~M ~O~HbIM 06pa30M UHTepOpeTHpOBaTb ~ HpUMeH~Tb co~ep~a~Hec~ B HeM peKOMeH~apHH. ~pU amoM Heo6xoduMo no0~epKuymb' ~mo nuxaxux cyu~ecmffeNub~x usMeNeNuu ff codep~canue peu,eusupyeMou py~conucu eueceno ne 6blJ10. . . .

HaunOHa~bHa~ aKa,~eMu~ HayK ope,~cTas~eT co60n HeKOMMep~eCKy~O opraHn~aun~o, o6~e,~nH~omy~o H3BeCTH~X AX, SaHUMalO~UXCH Hay~HO- TeXHn~eCK~Mn ncc~e,~osaHn~Mn, IIpe,~aHHbIX Free pa3suTu~ HayKu ~ TeXH~Ku ncoo~b~osaHn~ ux,~ocT~eHnn Ha sceo6mee Figaro. Ha OCHOBaHHU HO~HOMOHHU, ope,~ocTas~eHHux en B 1863 r. KoHrpeccoM, aKa,~eMmq nMeeT MaH,~aT, no KOTOpOMy oHa 06~3aHa OKaS~BaTb ~e~epa~bHOMy HpaBUTe~bCTBy KOHCy~bTaTHBHylO HOMO~b HO BOOpOCaM HayKH ~ TeXH~KH. ~]peS=eHTOM Ha~HOHa~bHOH aKa~eMun HayK RB~eTCH ~- p BLOC ~b6epTC. Ha~HOHa~bHaH TeXH~eCKaH aKa~eM~ 6bMa OCHOBaHa B 1964 r. no pacoop~eHn~o Ha~HOHa~bHOH aKa~eMHU HayK B Ka~eCTBe Hapa~e~bHOH Opt BM~alO~UXCH UH*eHepOB. OHa HO~bSyeTCH aBTOHOMUeH B OTHO~eHHU BOOpOCOB a~M~HUCTpa~H HpHeMa H~eHOB, HO pat C Ha~HoHa~bHoH aKa,~eMUeH HayK o6~3aHHocTH HO oKa3aHHIo KOHCy~bTaTHBHOn nOMO~n ~e,~epa~bHOMy HpaBuTe~bCTBy. Ha~HoHa~bHaH TeXHlIIIeCKa,[ aKa,~eMu~ TaK*e OKa3bIBaeT IIO~ep*Ky UH*eHepHbIM HpOrpaMMaM, HaDpaB~eHHbIM Ha y~OB~eTBOpeHHe Ha~HOHa~bHbIX Hy~, CHOC06CTByeT pa3BUTHIO IIpOCBe~eH~q ~ nCC~e,~OBaHHn ~ IIpuCy~aeT Harpa,~bI 3a Bbl~alo~HecH ,~OCT~eH~q B o6~acTn TeXH~KH. ~]pe3=eHTOM Ha~HOHa~bHOH TeXH~eCKOH aKa~eMun RB~eTCH ~-p Fapo~b,~ JIeH60BULl. IIHCTHTYT Me~HHbI 6bM y~pe~eH B 1970 r. HaunoH=bHon aKa~eMnen HayK c ~e~blO o6ecHeHuTb y~acTHe B=HbIX CHe~HaRuCTOB B COOTBeTCTBylO~nX o6~acTRx 3HaHHn B paCCMOTpeHHn BOIIpOCOB opraHH3aLlHn 3,~paBooxpaHeHHH. IIHCTHTYT ~yHKLlHOHupyeT B paMKaX 06~3aHHoCTen' B03~0*eHHbIX Ha Ha~HOHa~bHylO aKa,~eMHIO HayK 3aKOHOM KoHrpecca O Hpe,~ocTaB~eHHn KoHcy~bTa~n ~e,~epaRbHoMy HpaBuTe~bcTBy' a TaK*e B paMKaX CO DCTBeHHOH UHH~HaTHBbI HO OOpe~e~eHHIO BOOpOCOB Me~HHCKOH HOMO~H, ~CC~e,~OBaHHU ~ o6pa3osaHn~. ~]pe3~eHTOM ~HCTHTyTa Me~HHbI RB~HeTCH ~-p KeHHeT lI. IIIanH. Ha~HoHa~bHbIn Hay~HO-nCC~e,~OBaTe~bCKnn COBeT 6bM y~pe~eH Ha~HoHa~bHon aKa~eMUeH HayK B 1916 r. c ~e~blo HpuB~eHeHHR mnpOKOH Hay~HO-TeXHHHeCKOH 06ILleCTBeHHOCTlI K BbIIIO]IHeHlIlO 3a~aH, CTOH~UX Hepe~ aKa~eMnen B ~aHe paC~HpeH~ Hay~HbIX 3HaHlIlI lI OKa3aH~ KOHCy]IbTaTlIBHOlI IIOMOILllI ~e~epa~bHOMy HpaBUTe~bCTBy. ~)yHKpHOHUpyR B paMKaX o6~en HO~HT~K~, C+OpMy~HpOBaHHOH aKa~eMUeH, COBeT CT~ OCHOBHbIM OIIepaTlIBHbIM OpraHOM KaK H a~HOHa~bHOH aKa~eMHU HayK, TaK ~ Ha~HoHa~bHoH TeXHHHeCKOH aKa,~eMHU, pea~3yIo~HM UX pa6oTy B UHTepeCaX ~e,~epa~bHoro IIpaBuTe~bCTBa, IIInpOKHX KpyrOB Hace~eHHH' a TaK*e Hay~HO- TeXHHHeCKOn o6~ecTBeHHocTH. PYKOBO,~CTBO COBeTOM OCy~eCTB~HeTCH COBMeCTHO obeuMn aKa,~eMH~MU ~ IIHCTHTYTOM Me~HHbI. Hpe~ce~aTe~eM ~ 3aMeCTHTe~eM Hpe,~ce,~aTe~H H a~HOHa~bHOrO Hay~HO -nCC~e,~OBaTe~bCKOrO COBeTa RB~IOTCH COOTBeTCTBeHHO ~-p ~plOC ~b6epTC ~ ~-p tapO~b~ ~en60su~. IV

KOMlITET I10 IIEPECMOTPY PYKOBO,1;CTBA I10 CO,1;EP)KAHlIK) 11 lICIIOJIb30BAHlIK) JlAliOPATOPHbIX ^lIBOTHbIX J. Derrell Clark (Chairman), University of Georgia, College of Veterinary Medicine, Athens, Georgia Ransom L. Baldwin, University of California, Davis, California Kathryn A. Bayne, American Association for Accreditation of Laboratory Animal Care, Rockville, Maryland Marilyn J. Brown, Dartmouth College, Lebanon, New Hampshire G. F. Gebhart, University of Iowa, College of Medicine, Iowa City, Iowa Janet C. Gonder, Baxter Healthcare Corporation, Round Lake, Illinois Judith K. Gwathmey, Harvard Medical School, Boston, Massachusetts Michale E. Keeling, University of Texas M.D. Anderson Cancer Center, Bastrop, . . exas Dennis F. Kohn, Columbia University, College of Physicians & Surgeons, New York, New York J. Wesley Robb, Professor Emeritus, University of Southern California, Los Angeles, California Orville A. Smith, University of Washington, Seattle, Washington Jo Ann D. Steggerda, Champaign, Illinois John G. Vandenbergh, North Carolina State University, Raleigh, North Carolina William J. White, Charles River Laboratories, Wilmington, Massachusetts Sarah Williams-Blangero, Southwest Foundation for Biomedical Research, San Antonio, Texas John L. VandeBerg, Southwest Foundation for Biomedical Research, San Antonio, Texas (ex officio member) Staff Thomas L. Wolfle, Program Director Carol M. Rozmiarek, Project Assistant Norman Grossblatt, Editor v

COBET lIHCTtITYTA PECYPCOB JlAliOPATOPHbIX *lIBOTHbIX (ILAR) John L. VandeBerg (Chairman), Southwest Foundation for Biomedical Research, San Antonio, Texas Christian R. Abee, University of South Alabama, Mobile, Alabama J. Derrell Clark, University of Georgia, College of Veterinary Medicine, Athens, Georgia Muriel T. Davisson, The Jackson Laboratory, Bar Harbor, Maine Bennett Dyke, Southwest Foundation for Biomedical Research, San Antonio, Texas Neal L. First, University of Wisconsin, Madison, Wisconsin James W. Glosser, Massillon, Ohio John P. Hearn, Wisconsin Regional Primate Research Center, Madison Margaret S. Landi, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania Gail Martin, University of California, San Francisco, California Charles R. McCarthy, Kennedy Institute of Ethics, Georgetown University, Washington, D.C. Robert J. Russell, Harlan Sprague Dawley, Frederick, Maryland Richard C. Van Sluyters, University of California, Berkeley, California John G. Vandenbergh, North Carolina State University, Raleigh, North Carolina Peter A. Ward, University of Michigan Medical School, Ann Arbor, Michigan Thomas D. Pollard, The Johns Hopkins University School of Medicine, Baltimore, Maryland (ex officio member) Staff Eric A. Fischer, Director Thomas L. Wolfle, Program Director Mara L. Glenshaw, Research Assistant Carol M. Rozmiarek, Project Assistant IIHcTnTyT pecypcos ~abopaTopHux ~soTHb~x (ILA1R) 6bM OCHOBaH B 1952 r. Boy 3rn~0n HaL~noHa~bHoro HayqHo-ncc~e~osaTe~bcKoro coseTa. Bxo~ B cocTaB KOM~CCH~ no HayKaM o ACHE, ILARpa3paGaTbIsaeT nHCTpyKunn ~ pacupocTpaHneT lIH+OpMa~ Ho HayqH~M, TeXH~HeCK~M ~ 3THHeCK~M aCHeKTaM ~CHO~b30BaH~ *nsoTHux ~ ~pyrox 6no~oroqecKnx pecypcos s ncc~e~osaHn~x, ncII~TaHn~x oGyqeHnn. ILA1R cuocodcTsyeT obecneqeHnIo sucoKoKaqecTseHHoro ~ ryMaHHoro yoga 3a *nBOTHbIMn, a TaK*e IIpasn~bHoro ncIIo~b3osaHn~ *nsoTHbIx ~ anbTepHaTusHb~x Moseyed. ILA1R tyHK~HOH~pyeT B paMKaX Ha~HOHa~bHOH aKa~eMH~ HayK, OKa3bIBaSI KOHCy-11bTaTlIBHyIO IIOMOILlb te~epa~bHbIM HpaB~Te~bCTBeHHbIM yqpe*~eHH~M, CHe~Ha~HCTaM, 3aH~Ma~HMC~ ~CC~e~OBaHH~M~ B 06~aCTH 6HoMe,=~HHbI7 a TaK*e mnpOKOH 06~eCTBeHHoCTH. Vl

KOMlICCtIl1 I10 HAYKAM O *113HlI Thomas D. Pollard (Chairman), The Johns Hopkins University School of Medicine, Baltimore, Maryland Frederick R. Anderson, Cadwalader, Wickersham & Taft, Washington, D.C. John C. Bailar, III, McGill University, Montreal, Canada John E. Burris, Marine Biological Laboratory, Woods Hole, Massachusetts Michael T. Clegg, University of California, Riverside, California Glenn A. Crosby, Washington State University, Pullman, Washington Ursula W. Goodenough, Washington University, St. Louis, Missouri Susan E. Leeman, Boston University School of Medicine, Boston, Massachusetts Richard E. Lenski, Michigan State University, East Lansing, Michigan Thomas E. Lovejoy, Smithsonian Institution, Washington, D.C. Donald R. Mattison, University of Pittsburgh, Pittsburgh, Pennsylvania Joseph E. Murray, Wellesley Hills, Massachusetts Edward E. Penhoet, Chiron Corporation, Emeryville, California Emil A. Pulitzer, Research Institute for Fragrance Materials, Inc., Hackensack, New Jersey Malcolm C. Pike, University of Southern California School of Medicine, Los Angeles, California Henry C. Pitot, III, McArdle Laboratory for Cancer Research, Madison, Wisconsin Jonathan M. Samet, The Johns Hopkins University, Baltimore, Maryland Harold M. Schmeck, Jr., North Chatham, Massachusetts Carla J. Shatz, University of California, Berkeley, California John L. VandeBerg, Southwest Foundation for Biomedical Research, San Antonio, Texas Staff: Paul Gilman, Executive Director . . V11

lIPE~HC~OBME <<PYKOBO,~CTBO HO CO,~eP*aHHIO ~ ~CrIO~B3OBaHHIO ~a60PaTOPH~X ~BOTH~X>> (HMeHyeMOe Hoe PJ//COffO0CmffO) to BUepBMe ODy6~HKOBaHO B 1963 r. Ron, Ha3BaHHeM <<PYKOBO,~CTBO HO BUBaPH~M ~ CO,~eP*aHHIO a60PaTOPH~X *HBOTH~X>> ~ rIePeH3,~aHO B 1965, 1968, 1972, 1978 ~ 1985 rr. Locke r~epsoro sur~ycKa Py~cooodcmeo to pacr~pocTpaHeHo B KO~HeCTBe CBM~e 400 000 ~K3eM~HPOB; OHO rIO~B3YeTCH ~HPOK~M TIPH3HaHHeM KaK OCHOBHOH ~CTOIIH~K, PerJIaMeHTHPY]O~H TPe JOBaHH~ rIO CO,~eP*aHHIO ~ CrIO~B3OBaHHIO ~BOTH~X. IICXO,~H HS r~pe'~cTaB~eH~ O TOM, HTO PJ'~cooodcmeo ,~O~*HO {IePeCMaTPUBaTBCH C YTIeTOM H3MeHHIO~UXCH YC~OBHU ~ {IO~B~eH~ HOBOn nH~OpMaLlHn, B Hater ce'~BMoe H3~aHHe' BHeCeHEI H3MeHeH~ HOBBIe MaTepHa~BI. Ha3HaqeHHe py~coffo~cmffa' C~OpMy~HpOBaHHOe B rIopyqeHHn KOMuTeTy rIo'~roToBuTB rIepecMoTpeHHoe H3~aHHe <<pyKoBo'~cTBa rIo co'~ep~aHnIo ~ ncrIo~B3oBaHnIo ~a6opaTopHEIx *HBOTHEIX>>, COCTOUT B TOM, qTO6BI oKa3aTB rIoMo~B HayqHEIM yqpe;K,D;eH~M B o6ecrIeqeHHn co'~ep~aH~ ~ ncrIoJIB3oBaH~ *HBOTHEIX MeTO,~aMn, KOTOpLIe cq~TaIoTcH o6ocHoBaHHEIMn C HayqHOn, TeXH~qeCKOH ~ ryMaHUTapHOH TOqeK spent. Py~cooodcmeo TaK*e HpH3BaHO crIoco6cTBoBaTB nCCJIe,~OBaTeJI~M B peaJIn3aLlHn ux o6~3aHHocTen rIo aHupoBaHnIo ~ rIpoBe'~eHnIo 3KcrIepuMeHToB Ha *HBOTHEIX B COOTBeTCTBHn C CaMBIMn BBICOK~Mn HaYqHEIMn, rYMaHHEIMn ~ 3THqeCK~Mn {IP~HLlUTIaMH. IlpUBO~HMBIe peKOMeH~a~H OCHOBBIBaIOTCH Ha ODy6~HKOBaHHEIX ~aHHEIX, HayqHEIX Hp~H~HaX, MHeHH~X 3KCHepTOB ~ aUpO6HpOBaHHOM OHEITe rIpuMeHeHn~ MeTo,~os ~ rIpoL~e,~yp, cosMecTuM~Ix c TpebosaHn~Mn KaqeCTBeHHOrO lI ryMaHHOrO CO~ep~aH~ ~ ~CHO~B30BaH~ ~BOTHEIX. Ilpe,~ymne n3,~aH~ Py~cooodcmea 6~L~n rIo,~roTosJIeH~I ncK~oq~TeJI~Ho HpH HO,D;,D;ep*Ke Ha~HOHa~BHEIMU UHCTHTyTaMU 3~0pOBB~ (National Institutes of Health - NIH) ~ s~IrIycKa~ncB TurIorpa~nen IlpasuTe~BcTsa CIIIA. IX

x IIPE~0C~OBRE HacTo~mee n3~aHne ony6~nKoBaHo ups ~nHaHcoBon no~ep*Ke NIH, M~HUCTepCTBa Ce~BCKOrO X03~HCTBa, Y0paB~eHH~ HO ~e~aM BeTepaHOB OTHeHaTaHO B THHOrpa~H H a~HOHa~BHOH aKa~eMHU HayK, HTO CB~eTe~BCTByeT O ~HpOKOM paCHpOCTpaHeHHU Py~OffO0Cmffa. Py~cooodcmeo COCTOUT Ha HeT~peX Arab, HOCBH~eHH~X OCHOBH~M HaTIpaB3IeH~M lIpOrpaMMBI CO~ep~aH~ ~ ~CHO~B30BaH~ ~BOTHEIX: HpaB~a ~ 06SI3aHHoCTH Hay~HEIX y~pe~eHHU, yC~OBH~ CO~ep~aHH~ *HBOTHEIX, BeTep~HapHaSI HOMONYM ~ opraHH3a~H BuBapHH. B Ka~on Ha BTUX r~aB paCCMaTpUBaIOTCH KOHKpeTHEIe 06~3aHHoCTH pyKOBO~HTe~eH Hay~HEIX y'Ipe)K,D;eHlIlI, lIX KOMlICCIIlI lIO CO~ep~aHUIO ~ ~CHO~B30BaHUIO *HBOTHEIX, a TaK*e ncc~e,~osaTe~en ~ BeTeplIHapOB. B 1991 r. cr~euna~H~In KOMuTeT, C03,~aHH~In IIHCTuTyTOM pecypcos 60PaTOPHEIX *HBOTHEIX (ILAR), PeKOMeH,~OBa~ rIO,~rOTOBUTB rIepecMoTpeHHoe n3,~aHne Py~cooodcmea. B 1993 r. HaunoHa~BH~In Hay~Ho- ncc~e,~osaTe~BcKnn coseT ylIpe,~ KoMuTeT rIo rIepecMoTpy n3,~aHn <<PYKOBO,~CTBa rIO CO,~eP*aHUIO ~ ~CrIO~B30BaHUIO ~a60PaTOPHEIX ~BOTHEIX>>. B ero COCTaB BO~H 1 5 ~eHOB, B TOM ~nc~e Hay~H~Ie pa60TH~K~, seTep~Hap~I, a TaK*e ~Ua, rIPe,~CTaB~IO~He UHTePeCEI CrIeUHa~HCTOB r~O 6~08T~Ke 06~eCTBeHHOCTH rIO BOrIPOCaM 3a~HTEI ~BOTHEIX. Ilpe;K,D;e HeM HpUCTyHUTB K HePeCMOTPY PY~OffO0Cmffa, KOMUTeT 06PaT~CH K HaY~HOH ~ IIInpoKon 06~eCTBeHHOCTH C lIpH3BIBOM BBICKa3aTB 3aMelIaH~ B rIncBMeHHon ~n yCTHOn ~OpMe. KoMuTeT rIpoBe~ OTKpLITEIe 3ace'~aHH~ B Bam~HrToHe (~e'~epa~BHEIn oKpyr K°~YM6~) 1 ,~eKadp~ 1993 r., B caH- ~paHL~ncKo (KaJIn~opH~) 2 ~espaJI~ 1994 r. ~ B CeHT-JIy~Ce (Muccypu) 4 ~espa~ 1994 r. KoMuTeT paccMoTpe~ 3aMeHaHHH7 BBIcKa3aHHEIe Ha 3TuX 3ace'~aHH~x' a TaK*e rIOCTyrInBIIIne B rIncBMeHHoM B~,~e, ~ BK~IOIIn cy~ecTBeHHylo lIacTE rIpewIo~eHHn B HacToH~ee rIepecMoTpeHHoe H3,~aHHe Py~cooodcmea. KoMuTeT BBIpa~aeT rIpH3HaTe~BHocTB '~-py YH~B~MY II. teIo ~ '~-py ~eHHeTTy KO3HY 3a ux BK~a'~ B rIO~rOTOBKy HepBoro H3~aH~ py~offo~cmffa. B 1959 r. '~-p KO3H, 3aHUMaB~H HOCT rIpe3~eHTa KOMUCCHU rIo co'~ep~aHnIo ~BOTHEIX (Animal Care Panel - ACP), y~pe,~ KoMuTeT rIo paccMoTpeHmo 3THHeCKHX aCHeKTOB ~CHO~B30BaHH~ ~a60paTOpHEIX *HBOTHEIX, KOTOpLIU ~O~*eH 6~M H3yHUTB BOUpOCEI CO~ep~aHH~ ~ ~CHO~B30BaHH~ ~a60paTOpHEIX ~IBOTHEIX. ~pe~Ce~aTe~eM 3TOrO KOMUTeTa 6~M ~-p Fen, KOTOpLIU 6BICTpO rIp~IIIeJI K 3aK]IIOHeHUI0 0 TOM, HTO KOMUTeT He CMO*eT 06~eKTHBHO O~eHUTB HpOrpaMMBI HO ~CHO~B30BaHUIO ~a60paTOpHEIX *HBOTHEIX, He HMeH COOTBeTCTByIO~UX KpUTepHeB ~H TaKOH O~eHKH; ~pyrUMU C~OBaM~, B03HH~a HeO6XO~HMOCTB BBIpa60TKH HeKHX CTaH~apTOB. ~CHO~HUTe~BHEIU KOMUTeT ACP cor~ac~c~ C TaK~M HO~XO~OM ~ y~pe~ KoMuTeT no upo~eccuoHa~BH~IM CTaH,~aPTaM. CrIYCTH HeKOTOpOe BpeMSI NIH s~I,~a~ ACP KoHTpaKT Ha <<pa3pa6oTKy ~ o6ocHoBaHHe Hpo~eccHoHa~BHEIx cTaH'~apToB ~H BUBapHeB ncrIo~B3osaHH~ ~a6opaTopHEIx *HBOTHEIX>>. KoMuTeT rIo pa3pa6oTKe CTaH,~apTOB ,~H BuBapHeB rIO,~ rIpe'~ce'~aTe~BcTBoM'~-pa Ko3Ha ~ rIO,~rOTOB~ rIepBoe H3~aHHe <<pyKoBo'~cTBa rIo BuBap~M ~ ncrIo~B3oBaHnIo ~a6opaTopHEIx ~BOTHEIX>>. KoMuTeT rIo rIepeCMOTpy <<pyKoBo'~cTBa rIo co'~ep~aHnIo ~ ncrIoJIB3oBaHnIo ~a6opaTopHEIx *HBOTHEIX>> BBIpa~aeT 6~aro'~apHocTB COTpy,~H~KaM tIH~opMa~HoHHoro ~eHTpa rIo 3a~nTe *HBOTHEIX rIpH Ha~HoHa~BHon ce~BcKoxo3~ncTBeHHon 6~6~HoTeKe M~HucTepcTBa ce~BcKoro xo3~ncTBa C~A

[IPE,4LICJ7OBLIE 3a rIoMo~E B rIo~60pe 6~6~Horpa~ecKHx MaTepHa~os. bet ux rIoMo~n TaKaH Banana oKa3a~acB 6M Tpy~HO BurIo~HuMon. KoMuTeT TaK*e rIp~HOCHT 6~aro~apHocTE peUeH3eHTaM py~coffo~cmffa' r-Hy HopMaHy tpocc6~aTTy 3a pe~aKTHposaHHe pyKorIncH, r-*e K3POJI po3MapeK 3a rIpeKpacHylo TeXHHHeCKylO paboTy no HO~rOTOBKe MHOrOHUC~eHH~X BapHaHTOB pyKOHUCH, a TaK*e r-Hy TOMaCy BOJIB~Y, KOTOpMn pyKOBO~ BCeM HpO~eCCOM OT HaHa~a ~0 caMoro KOH~a. ~InTaTe~en7 o6Hapy*HBm~x 0~6KH ~n HpODyCK~, HpOCSIT HaUpaB~SITB 3aMeHaH~ ~ rIpe ~o~eH~ B I IHCTHTYT pecypcoB ~a6opaTopHux ~BOTHuX rIpH HaUnoHa~BHoM Hay~Ho-ncc~e'~oBaTe~BcKoM coBeTe: Institute of Laboratory Ani- mal Resources, National Research Council, 2101 Constitution Avenue, NW, Washington, DC 20418. Derrell Clark, Chairman Committee to Revise the Guide for the Care and Use of LaboratoryAnimals Xl

lIPE4HC~OBUE PE~TOPA HEPEBO4A t,ICHO~B30BaHHe ~BOTH~X B HEX ~CC~e~OBaH~X, TeCTHpOBaHHU ~ B rIpouccce oGy~eH~ ~s~qeTc~ HeoT~eM~eMon ~acTBIo cospeMeHHoro rIo3HaH~. HeCMOTpSI Ha pa3~HMe TOUKH 3peHUSI Ha HpO6~eMy BT~HOCTH HpUMeHeH~ *HB~X 06~eKTOB B KaHeCTBe ~KCHepUMeHTa~BH~X MO~e~eH, SIX Bryan, 6e3yc~osHo, 6ecueHeH. II,~e~ ryMaHHoro oTHomeHn~, Hame,~ma~ supa~eHne B KOCH 3R s (coKpa~eHHe Ko~HecTBa *HBOTH~X, ~CHO~B3yeM~X B 3KCTIeplIMeHTaX, yCOBepIIIeHCTBOBaHlIe MeTO~OB OX ~CHO~B30BaHH~ ~ 3aMeHa BOTH~X B ~KCHepUMeHTe), ~ B03paCTaIO~He Tpe60BaH~ K KaHeCTBy HEX lICC3Ie~OBaHHU BBI~BUraIOT Ha HepBBIU H~aH BOUpOCEI CO~ep~aHH CHO~B30BaH~ ~a60paTOpHEIX ~BOTHEIX. Ilpe,~araeMa~ BHUMaHHIO ~nTaTe~en KHura BLOTCH nepeso~oM ce~Moro H3~aHH~ <<PyKOBO~CTBa HO CO~ep~aHUIO ~ ~CHO~B30BaHUIO ~a60paTOpHEIX ~IBOTHEIX>>, HO~rOTOB~eHHOrO Be~y~HMU CHeUHa~HCTaMU B paMKaX HpOeKTa, yTBep)K,D;eHHOrO IlpaB~eHHeM HaU~OHa~BHOrO Hay~HO-HCC~e~OBaTe~BCKOrO COBeTa (CILIA). C lICTOplIelI C03~aH~, OCHOBHEIMU Hp~HUHDaMU ~ CTpyKTypOH BTOrO pyKOBO~CTBa 3HaKOM~T <<UpuMe~aHne>>, <<Upe~nc~osue>> ~ <<BBe~eHHe>>, HaTIlICaHHEIe K OpHr~Ha~BHOMy H3~aHUIO ~ B~IOHeHHEIe B ~aHHEIU HepeBO~. PYK°B°~CTB° o6pa~eHo K mHpOKOH Me*~yHapo~HoH ay~HTOpHU HarIncaHo B ~OpMe o6~nx peKOMeH~aUnn. ABTOPLI, orInpa~cB Ha BBICOKne Hay~HEIe, ryMaHHEIe ~ 3THHecKne rIp~HunrIBI, 6o~B~oe BHuMaHHe y'~e~HIoT 3aKoHo~aTe~EHon 6a3e, pery~Hpylo~en oTHomeHH~ B ~aHHon o6~acTH; C ~yHKUn~M KOMuCCHn rIo co~ep~aHnIo ~ ncrIoJIB3oBaHnIo *HBOTHEIX, co3~aHHEIx B HaylIHEIX ylIpe;KD;eHH~X; rIO~rOTOBKe ~ po~n CrIeUna~nCTOB, OTBeTCTBeHHEIX 3a rIpon3Bo'~cTBo *HBOTHEIX, yXo'~ 3a HuMn ~ BOB~elIeHHe B 3KcrIepuMeHT. paccMoTpeHEI BorIpocEI co3~aH~ cooTBeTcTByIo~nx ~3~ecKHx ~ counaJIBHEIx yCJIOBHn co~ep~aHH~ JIa6opaTopHEIx *HBOTHEIX, rIpaB~ ux 3aKylIKH lI TpaHCTIOpTHpOBKlI, lIpOBe~eHHSI 3KCTIepUMeHTaJIBHEIX lIpOue'~yp lI ryMaHHOrO yMepILlBJIeH~ ~IBOTHEIX. Bo~B~oe BHuMaHHe y~e~eHo OCHOBHEIM XapaKTeplICTlIKaM lIOMeILleHlIlI BlIBaplISI. ~eHHOCTB n3~aHn~ HOBBI~aeT OO~HpHEIU CHUCOK ~HTepaTypLI, 3aMBIKaIO~H He TO~BKO Ka~yIO H3 HeTEIpeX r3IaB, HO lI OXBaTEIBaIO~H rpyHHEI OT~e~BHEIX BOUpOCOB, HTO H03BO~HeT ~nTaTe~Io rIo,~po6Ho 03HaKoMuTBc~ c nHTepecyIomen ero rIpo6~eMon. CrIncoK OpraHlI3aUlIlI, lIMeIO~UX OTHO~eHHe K ~a JOpaTOpHEIM *HBOTHEIM, TaK*e I03BOJISIeT paCIIIlIplITB ~CTO~H~KH HO~y~eH~ UH~OpMaUHH. XOIIeTCSI Ha~e~TBCH, HTO HepeBO~ <<PyKOBO~CTBa HO CO~ep~aHUIO ~ lICTIOJIB30BaHUIO JIa60paTOpHEIX *HBOTHEIX>>, SIBJIHIOILllIHCH, HO*aJIylI, CaMBIM COBpeMeHHEIM ~ 0606~aIO~HM n3~aHneM Ha 3Ty TeMy Ha pyCCKOM H3BIKe, BBI30BeT He TO~BKO UHTepeC y CHeUHa~HCTOB, HO ~ CTaHeT ~eUCTBUTe~BHO lIpaKTlIIIeCKlIM pyKOBO~CTBOM B UX ~e~Te~BHOCTH. H. XapJIaMosa . . . X111

or~EHME BBe~eHHe ~OCTaHOB~eHH~,HpaBH~aH Hp~H~M, 2 KpuTepun OL~eHK~, 3 Ce~BcKoxo3~ncTseHHme solute, 4 HeTpa~HOHHMeB~M ~ BOTH~X, 5 Ilo~esue ncc~e,~osaH~, 6 3aK~o~eHne, 6 JInTepaTypa, 7 Maya 1. Ilpas~a ~ 06SI3aHHoCTH HEX y~pe)K,D;eHHU K°HTP°~B 3a co~ep~aHHeM ~ ncHo~B3oBaHHeM ~BOTHuX,10 BeTep~HapHaH HOMONYM, 14 Ksa~nKau~ ~ r~o,~roTosKa r~epcoHa~a' 14 FurneHa Tpy,~a ~ 6e3or~acHocT~ r~epcoHa~a' 15 JInTepaTypa, 21 Lana 2. YC~OBH~CO~ep~aHUH ~ BOTH~X On3~ecKa~ opera, 24 OpraHH3a~H HOBe~eHUH ~ BOTH~X, 40 Bor~pocm co,~ep~aH~ ~ BOTH~X, 42 ~o~0ep~aHHe HODy~HH *HBOTH~X, 5 1 JInTepaTypa, 53 xv 9 23

OT~lB1TEHRE Lana 3. BeTep~HapHa~ PROMOS 3aKyUKa ~ TpaHCHOpTHpOBKa ~BOTH~X, 62 IlpO+~aKT~eCKa~ ma, 63 X~pypr~, 66 Bond, aware ~ aHecTe3~, 70 3nTaHa3~, 72 JInTepaTypa, 73 Maya 4. 060py,~osaHne susap~ ~yHK~HOHa~BHMe 30HM, 78 I IHCTPYKLIHU rIo cTponTeJIBcTsy susapnes, 79 IIOMemeH~ ,~JI~ aCerITnIIeCKOn x~pyprnn, 85 JInTepaTypa, 87 Ilp~o~eHne A. Bu6~norpa+~ecKnn yKa3aTe~ Ilp~o~eHne B. OpraHn3aunn, nMe~omne OTHO~eHHe K ~a60paTOpH~M *HBOTH~M Ilp~o~eHne B. HeKOTOpme ~e,~epa~Hme 3aKOHu, KaCalO~HeCH CO~ep~aH~ ~ ~CHO~B30BaH~ ~BOTH~X Ilp~o~eHHe if. ~O~HT~Ka C~6BI 3~paBooxp lI rOCy~apCTBeHHEIe Hi, KaCaIO~HeCH CO~ep~aH~ ~ ~CHO~B30BaH~ ~BOTHEIX Ilpe~MeTHEIU yKa3aTe~B XVI 61 77 88 108 121 123 126

Next: Introduction »
Guide for the Care and Use of Laboratory Animals -- Russian Version Get This Book
×
Buy Paperback | $47.00
MyNAP members save 10% online.
Login or Register to save!
Download Free PDF
  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  6. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  7. ×

    View our suggested citation for this chapter.

    « Back Next »
  8. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!