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Suggested Citation:"Appendix B: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations. Washington, DC: The National Academies Press. doi: 10.17226/25952.
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Page 64
Suggested Citation:"Appendix B: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations. Washington, DC: The National Academies Press. doi: 10.17226/25952.
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Page 65
Suggested Citation:"Appendix B: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations. Washington, DC: The National Academies Press. doi: 10.17226/25952.
×
Page 66
Suggested Citation:"Appendix B: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations. Washington, DC: The National Academies Press. doi: 10.17226/25952.
×
Page 67
Suggested Citation:"Appendix B: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations. Washington, DC: The National Academies Press. doi: 10.17226/25952.
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Page 68

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Appendix B Public Meeting Agendas First Committee Meeting for the Committee to Review EPA’s TSCA Systematic Review Guidance Document National Academy of Sciences Lecture Room 2101 Constitution Avenue, NW Washington, DC 20418 PUBLIC AGENDA FRIDAY, FEBRUARY 28, 2020 – 9:15 am–12:00 pm (Eastern) MEETING OBJECTIVES • Hear presentations from EPA on Systematic Review under TSCA • Learn about systematic review principles FRIDAY, FEBRUARY 28, 2020 OPEN SESSION (NAS, Lecture Room) 9:15 Purpose of Open Session and Introduction of Committee Members Jonathan Samet Chair, Committee to Review EPA’s TSCA Systematic Review Guidance Document Dean, Colorado School of Public Health 9:30 Systematic Review Under TSCA Susanna Blair and Iris Camacho, EPA Office of Pollution Prevention and Toxics 11:30 Opportunity for Public Comments to National Academies Committee Each speaker has a maximum time limit of 5 minutes. Accompanying written materials are encouraged. 12:00 Adjourn 64 Prepublication Copy

Appendix B Public Agenda for Virtual Meeting 2.1 for the Committee to Review EPA’s TSCA Systematic Review Guidance Document FRIDAY, JUNE 19, 2020 – 10:00 am–1:00 pm (Eastern) MEETING OBJECTIVE • Learn EPA’s innovations in literature searching and screening to identify relevant scientific studies FRIDAY, JUNE 19, 2020 10:00 Purpose of Open Session and Introduction of Committee Members Jonathan Samet Chair, Committee to Review EPA’s TSCA Systematic Review Guidance Document Dean, Colorado School of Public Health 10:05 Overview of TSCA Risk Evaluation Process Stan Barone, Deputy Director, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention 10:20 Innovations in Searching and Screening Literature Kellie Fay, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention 10:50 Committee Discussion 11:20 Break 11:25 Automated Literature Prioritization Methods in SWIFT Review Chantel Nicolas, EPA Office of Chemical Safety and Pollution Prevention, Office of Pollution Prevention and Toxics Electronic Screening in DistillerSR and SWIFT ActiveScreener Francesca Branch, EPA Office of Chemical Safety and Pollution Prevention, Office of Pollution Prevention and Toxics 11:50 Committee Discussion 12:00 Break 12:05 Interactive Breakout Sessions • These breakout sessions will discuss videos that are prerecorded and posted on the TSCA Systematic Review study website. Viewing of these videos prior to participating in the session is necessary to fully participate. Discussion moderators will pose questions from the committee and the public during the breakout session to the poster presenters. Breakout Session 1: The Role of PECO Statements, Search Criteria, and Templates in Searching and Screening Moderated by Karen Robinson Prepublication Copy 65

The Use of Systematic Review in EPA’s Toxic Substances Control Act Risk Evaluations Videos discussed: o Evidence Mapping of Gray Literature Under TSCA: A Gray Literature Decision Tree Framework  Yousuf Ahmad, Risk Assessment Division, EPA Chemical Safety and Pollution Prevention, Office of Pollution Prevention and Toxics o Strategy for Developing Literature Search Strings to Identify Publications Containing Environmental Fate and Transport and Physical-Chemical Property Data  Amina Wilkins, EPA Office of Research and Development Breakout Session 2: Evidence Mapping Through Prioritizing, Pre-Screening, and Beyond Moderated by Katya Tsaioun Videos discussed: o Evidence Mapping for Engineering and Exposure: Literature Search, Prioritization, and Pre-Screening Strategy  Katherine Phillips, EPA Office of Research and Development o Evidence Mapping for Engineering and Exposure: Part B—Title/Abstract and Full-Text Screening  Yadi Lopez, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention o Evidence Mapping of Environmental and Human Health Hazard Evidence: Phthalic Anhydride Example  Kellie Fay, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention 12:55 Report Back from Breakouts 1:00 Adjourn Public Session Public Agenda for Virtual Meeting 2.2 for the Committee to Review EPA’s TSCA Systematic Review Guidance Document THURSDAY, JULY 23, 2020 – 2:30 pm–5:20 pm (Eastern) MEETING OBJECTIVE • Provide a summary of EPA’s innovations in the TSCA data evaluation and evidence integration process THURSDAY, JULY 23, 2020 2:30 Purpose of Open Session and Introduction of Committee Members Jonathan Samet Chair, Committee to Review EPA’s TSCA Systematic Review Guidance Document Dean, Colorado School of Public Health 2:35 Introductions from EPA 66 Prepublication Copy

Appendix B 2:40 Data Evaluation Process and How Scoring Is Applied Francesca Branch, EPA Office of Chemical Safety and Pollution Prevention, Office of Pollution Prevention and Toxics 3:10 Comparison of Different Data Evaluation Procedures Tracey Woodruff, Program on Reproductive Health and the Environment, University of California, San Francisco 3:20 Committee Discussion 3:50 Evidence Integration Supporting Hazard and Exposure Assessments Stan Barone, Deputy Director, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention Eva Wong, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention 4:10 Committee Discussion 4:40 Public Comments (each presenter has a 3-minute limit) Suzanne Fluharty, Yurok Tribe Environmental Program Julie Goodman, Gradient Ross Henderson, CAREM LLC Patricia Koman, self Stefanus Muryanto, UNTAG University in Semarang, INDONESIA Steve Risotto, American Chemistry Council Robert Sussman, Sussman & Associates Anthony Tweedale, R.I.S.K. Consultancy Daniele Wikoff, ToxStrategies 5:20 Adjourn Open Session Public Agenda for Virtual Meeting 2.3 for the Committee to Review EPA’s TSCA Systematic Review Guidance Document MONDAY, AUGUST 24, 2020 – 2:30 pm–4:55 pm (Eastern) MEETING OBJECTIVE • To hear details about EPA’s innovations in the TSCA data evaluation and evidence integration process MONDAY, AUGUST 24, 2020 2:30 Purpose of Open Session and Introduction of Committee Members Jonathan Samet Chair, Committee to Review EPA’s TSCA Systematic Review Guidance Document Dean, Colorado School of Public Health Prepublication Copy 67

The Use of Systematic Review in EPA’s Toxic Substances Control Act Risk Evaluations 2:35 Discussion of Questions About the TSCA Process Stan Barone, Deputy Director, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention 2:50 Discussion and clarifications on approach from EPA (Discussion time 35 minutes) 3:25 Break (10 minutes) 3:35 Interactive Breakout Sessions • These breakout sessions will discuss videos which are prerecorded and posted on the TSCA Systematic Review study website. Viewing of these videos prior to participating in the session is necessary to fully participate. Discussion moderators will pose questions from the committee and the public during the breakout session to the poster presenters. Breakout Session 1: Evaluation and Scoring Moderated by Bryan Brooks Videos Discussed: o Data Evaluation for Physical-Chemical and Fate Properties Under TSCA  Tameka Taylor, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention o Data Evaluation for Exposure and Engineering Studies Under TSCA  Nerija Orentas, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention o Data Evaluation for Environmental Hazard Studies Under TSCA  Amelia Nguyen, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention o Data Evaluation for Animal Toxicity and In Vitro Studies to Support Human Health Hazard Under TSCA  Amy Benson, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention o Data Evaluation for Epidemiological Studies Under TSCA  Francesca Branch, EPA Office of Chemical Safety and Pollution Prevention, Office of Pollution Prevention and Toxics Breakout Session 2: Evidence Integration Moderated by Jessica Myers Videos discussed: o Evidence Integration of Physical-Chemical and Fate Property Data Under TSCA  Marcy Card, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention o Evidence Integration of Exposure Data Under TSCA  Eva Wong and Ariel Hou, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention o Evidence Integration of Environmental and Human Health Hazard Data Under TSCA  Kara Koehrn, Risk Assessment Division, EPA Office of Pollution Prevention and Toxics, Office of Chemical Safety and Pollution Prevention 4:20 Discussion Following Breakouts Groups, Recap of Breakouts 4:55 Adjourn Public Session 68 Prepublication Copy

Next: Appendix C: Documents Reviewed by the Committee »
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Systematic review - a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies - has become the foundation for assessing evidence to be used for decision making in a variety of health contexts, including health care and public health.

At the request of the Environmental Protection Agency (EPA), this publication reviews EPA's 2018 guidance document Application of Systematic Review in TSCA (Toxic Substances and Control Act) Risk Evaluations and associated materials to determine whether the process is comprehensive, workable, objective, and transparent.

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