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Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
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Page 67
Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 68
Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 69
Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 70
Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 71
Suggested Citation:"Appendix B: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2020. Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25937.
×
Page 72

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B Workshop Agenda Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease— A Virtual Workshop June 25, 2020, via Zoom Hosted by the National Academies of Sciences, Engineering, and Medicine’s Forum on Neuroscience and Nervous System Disorders in Collaboration with the Board on Environmental Studies and Toxicology Workshop Objectives: This public workshop will bring together experts and key stakeholders from academia, government, industry, and nonprofit orga- nizations to explore the current knowledge landscape and future oppor- tunities in neurotoxicology. Invited presentations and discussions will be designed to: • Provide an overview of what is known about neurotoxic exposures and how they lead to neurodevelopmental and neurodegenerative disorders; • Explore how new technologies can be harnessed to identify previ- ously unknown neurotoxic chemicals; • Consider whether algorithms can be developed to better predict the effects of cumulative exposures and interactions across the life span on brain health; and • Discuss research gaps and collaborative opportunities between neuroscientists and environmental health scientists. 67 PREPUBLICATION COPY—Uncorrected Proofs

68 ENVIRONMENTAL NEUROSCIENCE 10:00–10:15 a.m. Welcome and opening remarks Frances Jensen, University of Pennsylvania, Neurosci- ence Forum Co-Chair Walter Koroshetz, National Institute of Neurological Disorders and Stroke, Neuroscience Forum Member and Workshop Co-Chair 10:15–10:40 a.m. Opening talk—Chemical exposures: The ignored envi- ronmental risk factor for neurodegenerative diseases and neurodevelopmental disorders Deborah Cory-Slechta, University of Rochester, Work- shop Co-Chair Session I: What Are the Neurotoxicants? Discussion questions: • What neurotoxicants should we be concerned about? • How can they be measured? • How can we measure their effects on populations and on individuals? 10:40–10:45 a.m. Session overview Deborah Cory-Slechta, University of Rochester, Work- shop Co-Chair and Session Moderator 10:45–11:00 a.m. Exposure to neurotoxic chemicals and neurodevelop- mental disease Tracey Woodruff, University of California, San Francisco 11:00–11:15 a.m. Environmental contributors to neurodegeneration: Why not measure everything? Gary Miller, Columbia University 11:15 a.m.– Panel discussion and Q&A 12:00 p.m. The two speakers above will be joined by panelists: Jennifer McPartland, Environmental Defense Fund Brenda Eskenazi, University of California, Berkeley PREPUBLICATION COPY—Uncorrected Proofs

APPENDIX B 69 12:00–12:30 p.m. Break Session II: Biology of Toxicant Interaction with the Nervous System Discussion question: • What is known about the biology of how “common” exposures to chemical and particulate toxicants might alter nervous system development or contribute to neurodegeneration? 12:30–12:35 p.m. Session overview David Jett, National Institute of Neurological Disor- der and Stroke, Session moderator 12:35–12:50 p.m. Exploiting genetics to identify environmental risks for autism Mark Zylka, University of North Carolina at Chapel Hill 12:50–1:05 p.m. LRRK2 activation as a common mechanism of envi- ronmental toxicant-induced Parkinson’s disease J. Timothy Greenamyre, University of Pittsburgh 1:05–1:20 p.m. Environmental gerogens in the Alzheimer’s disease exposome: Air pollution and cigarettes Caleb Finch, University of Southern California 1:20–2:15 p.m. Panel discussion and Q&A The three speakers above will be joined by panelists: Helena Hogberg, Johns Hopkins University Tomás Guilarte, Florida International University 2:15–2:30 p.m. Break Session III: Chemical Toxicants as Drivers of Abnormal Neurodevelopment and Neurodegeneration Discussion questions: • What is the level of evidence for chemical toxicants as drivers of abnormal neurodevelopment and neurodegeneration? PREPUBLICATION COPY—Uncorrected Proofs

70 ENVIRONMENTAL NEUROSCIENCE • What research is needed to launch prevention efforts: either treat- ments or policy changes? 2:30–2:35 p.m. Session overview Walter Koroshetz, National Institute of Neurological Disorders and Stroke, Workshop Co-Chair and Ses- sion Co-Moderator Allison Willis, University of Pennsylvania, Session Co-Moderator 2:35–2:50 p.m. A developmental perspective on early-life exposures to neurotoxicants David Bellinger, Boston Children’s Hospital 2:50–3:05 p.m. In utero endocrine-disrupting chemical (EDC) expo- sure may reprogram the adult mouse brain: A role for epigenetics Marisa Bartolomei, University of Pennsylvania 3:05–3:20 p.m. Translational research on the role of developmental pesticide exposure and ADHD Jason Richardson, Florida International University 3:20–3:35 p.m. Using gene–environment interactions and omics approaches to understand neurodegenerative disease etiology Beate Ritz, University of California, Los Angeles 3:35–3:50 p.m. Exposure to air pollution and risk of Alzheimer’s disease Andrew Petkus, University of Southern California 3:50–4:05 p.m. Identification and validation of amyotrophic lateral sclerosis environmental risk factors Eva Feldman, University of Michigan 4:05–4:30 p.m. Panel discussion and Q&A Panel composed of speakers above 4:30–4:45 p.m. Break PREPUBLICATION COPY—Uncorrected Proofs

APPENDIX B 71 Session IV: Future Directions Discussion questions: • What are the critical research gaps, next steps, and promising areas for future action? • What opportunities are there for collaboration among neuroscien- tists and environmental health scientists? 4:45–4:50 p.m. Reflections from the workshop co-chairs Deborah Cory-Slechta, University of Rochester Walter Koroshetz, National Institute of Neurological Disorders and Stroke 4:50–5:15 p.m. “Lightning round” remarks (5 minutes each) Stanley Barone, Environmental Protection Agency Ray Dorsey, University of Rochester Medical Center Carl Hill, Alzheimer’s Association Devon Payne-Sturges, University of Maryland Richard Woychik, National Institute of Environmental Health Sciences 5:15 p.m. Additional discussion with speakers, panelists, and audience members 5:30 p.m. Adjourn workshop PREPUBLICATION COPY—Uncorrected Proofs

PREPUBLICATION COPY—Uncorrected Proofs

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Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical.

On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

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