Appendix D
Workshop Program
Thursday, September 6, 1990
Lecture Room, National Academy of Sciences
2101 Constitution Ave., NW
Washington, DC
9:00 |
Introduction and Objectives: Kenny Crump, Clement Associates; Chairman |
9:15 |
Definition and Application of MTD |
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Presenter: Eugene McConnell, Raleigh, NC |
9:45 |
Discussants: John Emmerson, Eli Lilly and Co.; Ian Munro, University of Guelph |
10:05 |
Questions and Comments |
10:15 |
Break |
10:30 |
Correlations between the MTD and Measures of Carcinogenic Potency: Implications for Risk Assessment |
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Presenter: Daniel Krewski, Health and Welfare Canada |
11:15 |
Discussants: Kenny Crump, Clement Associates; Lauren Zeise, California Department of Health Services; Thomas Starr, Environ Corp.; |
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Edmund Crouch, Cambridge Environmental, Inc. |
12:00 |
Questions and Comments |
12:30 |
Lunch |
2:00 |
What are Bioassays Conducted at the MTD Telling Us? |
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Presenter: Bruce Ames, University of California, Berkeley |
2:45 |
Discussants: Michael Gallo, University of Medicine and Dentistry of New Jersey; David Gaylor, National Center for Toxicological Research |
3:15 |
Questions and Comments |
3:30 |
Break |
3:45 |
General Discussion |
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Leader: Kenny Crump, Clement Associates |
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Issues: |
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• The basis of the observed correlation between the MTD and measures of carcinogenic potency • The possible influence on biological processes of dosing at this level • The implications for the design of rodent bioassays • The implications for carcinogenic risk assessment |
5:00 |
Adjourn |