National Academies Press: OpenBook

Issues in Risk Assessment (1993)

Chapter: Appendix D Workshop Program

« Previous: Appendix C Federal Liaison Group
Suggested Citation:"Appendix D Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×

Appendix D
Workshop Program

Thursday, September 6, 1990

Lecture Room, National Academy of Sciences

2101 Constitution Ave., NW

Washington, DC

9:00

Introduction and Objectives: Kenny Crump, Clement Associates; Chairman

9:15

Definition and Application of MTD

 

Presenter: Eugene McConnell, Raleigh, NC

9:45

Discussants: John Emmerson, Eli Lilly and Co.; Ian Munro, University of Guelph

10:05

Questions and Comments

10:15

Break

10:30

Correlations between the MTD and Measures of Carcinogenic Potency: Implications for Risk Assessment

 

Presenter: Daniel Krewski, Health and Welfare Canada

11:15

Discussants: Kenny Crump, Clement Associates; Lauren Zeise, California Department of Health Services; Thomas Starr, Environ Corp.;

Suggested Citation:"Appendix D Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×

 

Edmund Crouch, Cambridge Environmental, Inc.

12:00

Questions and Comments

12:30

Lunch

2:00

What are Bioassays Conducted at the MTD Telling Us?

 

Presenter: Bruce Ames, University of California, Berkeley

2:45

Discussants: Michael Gallo, University of Medicine and Dentistry of New Jersey; David Gaylor, National Center for Toxicological Research

3:15

Questions and Comments

3:30

Break

3:45

General Discussion

 

Leader: Kenny Crump, Clement Associates

 

Issues:

 

• The basis of the observed correlation between the MTD and measures of carcinogenic potency

• The possible influence on biological processes of dosing at this level

• The implications for the design of rodent bioassays

• The implications for carcinogenic risk assessment

5:00

Adjourn

Suggested Citation:"Appendix D Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×
Page 95
Suggested Citation:"Appendix D Workshop Program ." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×
Page 96
Next: Appendix E Workshop Attendees »
Issues in Risk Assessment Get This Book
×
Buy Paperback | $65.00
MyNAP members save 10% online.
Login or Register to save!
Download Free PDF

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.

The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures.

The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    Switch between the Original Pages, where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text.

    « Back Next »
  6. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  7. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  8. ×

    View our suggested citation for this chapter.

    « Back Next »
  9. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!