National Academies Press: OpenBook

Issues in Risk Assessment (1993)

Chapter: COMPONENTS OF THE 1983 FRAMEWORK

« Previous: 2 Scope of Ecological Risk Assessment
Suggested Citation:"COMPONENTS OF THE 1983 FRAMEWORK." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×

3
Revision of 1983 Framework To Incorporate Ecological Risk Assessment

COMPONENTS OF THE 1983 FRAMEWORK

Risk Assessment in the Federal Government: Managing the Process (NRC, 1983), often called the "Red Book," proposed a conceptual framework for risk assessment that incorporates research, risk assessment, and risk management (Figure 3-1). Risk assessment was defined as "the characterization of the potential adverse health effects of human exposures to environmental hazards." The overall scheme and terminology proposed in the 1983 report entailed hazard identification, dose-response assessment, exposure assessment, and risk characterization. Hazard identification was defined as "the process of determining whether exposure to an agent can cause an increase in the incidence of a health condition," including "characterizing the nature and strength of the evidence of causation.'' Dose-response assessment was defined as "the process of characterizing the relation between the dose of an agent administered or received and the incidence of an adverse health effect … as a function of human exposure to the agent," accounting for exposure intensity, age, sex, lifestyle, and other variables affecting human health responses to hazardous agents. Exposure assessment was defined as "the process of measuring or estimating the intensity, frequency, and duration of human exposures to an agent currently present in the environment or of estimating hypothetical exposures that might arise from the release of new chemicals into the environment." Risk characterization was defined

Suggested Citation:"COMPONENTS OF THE 1983 FRAMEWORK." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×

FIGURE 3-1 Elements of risk assessment and risk management.

Suggested Citation:"COMPONENTS OF THE 1983 FRAMEWORK." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×
Page 249
Suggested Citation:"COMPONENTS OF THE 1983 FRAMEWORK." National Research Council. 1993. Issues in Risk Assessment. Washington, DC: The National Academies Press. doi: 10.17226/2078.
×
Page 250
Next: CONSISTENCY OF CASE STUDIES WITH THE 1983 FRAMEWORK »
Issues in Risk Assessment Get This Book
×
Buy Paperback | $65.00
MyNAP members save 10% online.
Login or Register to save!
Download Free PDF

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.

The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures.

The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    Switch between the Original Pages, where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text.

    « Back Next »
  6. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  7. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  8. ×

    View our suggested citation for this chapter.

    « Back Next »
  9. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!